LCE4A and PLSCR3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LCE4A	PLSCR3
Description		late cornified envelope 4A	phospholipid scramblase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleus Mitochondrion Mitochondrial Inner Membrane Cytosol Plasma Membrane Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Magnesium Ion Binding Calcium Ion Binding Protein Binding SH3 Domain Binding Phospholipid Scramblase Activity Lead Ion Binding Mercury Ion Binding Calcium-dependent Protein Binding
	Biological Process	Epidermis Development Keratinization	Lipid Transport Apoptotic Process Mitochondrial Membrane Organization Plasma Membrane Phospholipid Scrambling Glucose Homeostasis Cholesterol Homeostasis Regulation Of Apoptotic Process Cellular Response To Lipopolysaccharide Regulation Of Release Of Cytochrome C From Mitochondria
Pathways		Formation of the cornified envelope
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		79 interacting genes: ADAMTSL4 ALPP CRCT1 CREB5 CYSRT1 FUCA2 GRN HOXA1 HSD3B7 KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP17-1 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE5A MDFI MEOX2 NBPF19 NOTCH2NLA NUFIP2 OTX1 P4HB PLSCR1 PLSCR3 RGS17 RGS19 RGS20 RNF111 SLC39A7 SMCP SPRY1 SPRY2 TGM1 TRIM42 TSPAN4 VASN VWC2 ZNF655	34 interacting genes: ACTMAP AIPL1 C10orf55 C22orf39 CATSPER1 COL8A1 HOXA1 INCA1 KRTAP11-1 KRTAP15-1 KRTAP19-6 KRTAP19-7 KRTAP3-2 KRTAP3-3 KRTAP6-1 LCE1C LCE2B LCE4A LCE5A MAPKBP1 NAA10 NXPE2 PITX1 PLSCR1 PRKCD RUNX1T1 S100A7L2 SMCP STK16 TNIP3 TNS2 TRIP13 WWOX ZIC1
Entrez ID		199834	57048
HPRD ID		17264	07400
Ensembl ID		ENSG00000187170	ENSG00000187838
Uniprot IDs		Q5TA78	Q9NRY6
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Epidermis Development Keratinization Tissue Development Hair Cycle Protein Binding Cytosol Lead Ion Binding Identical Protein Binding Mercury Ion Binding Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Bud Elongation Involved In Lung Branching Interstitial Matrix Regulation Of Lens Fiber Cell Differentiation	Intermediate Filament Keratinization
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