LCE4A and KRTAP5-2

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		LCE4A	KRTAP5-2
Description		late cornified envelope 4A	keratin associated protein 5-2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Cytosol Intermediate Filament
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Epidermis Development Keratinization
Pathways		Formation of the cornified envelope	Keratinization
Drugs			Beta-D-Glucose Pidolic acid
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		79 interacting genes: ADAMTSL4 ALPP CRCT1 CREB5 CYSRT1 FUCA2 GRN HOXA1 HSD3B7 KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP17-1 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE5A MDFI MEOX2 NBPF19 NOTCH2NLA NUFIP2 OTX1 P4HB PLSCR1 PLSCR3 RGS17 RGS19 RGS20 RNF111 SLC39A7 SMCP SPRY1 SPRY2 TGM1 TRIM42 TSPAN4 VASN VWC2 ZNF655	61 interacting genes: ADAMTSL4 AP4M1 CRCT1 CREB5 CRY2 DHRS1 DLGAP3 EMC7 FAM76B FUCA2 HOXA1 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP2-3 KRTAP2-4 KRTAP4-11 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 LMNTD2 MACO1 MEOX2 MT1B NUFIP2 OPCML SLC13A5 SMCP TACSTD2 UBE2I
Entrez ID		199834	440021
HPRD ID		17264	17249
Ensembl ID		ENSG00000187170	ENSG00000205867
Uniprot IDs		Q5TA78	Q701N4
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Epidermis Development Keratinization Tissue Development Hair Cycle Protein Binding Cytosol Lead Ion Binding Identical Protein Binding Mercury Ion Binding Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Bud Elongation Involved In Lung Branching Interstitial Matrix Regulation Of Lens Fiber Cell Differentiation	Intermediate Filament Keratinization Epidermis Development Keratin Filament Tissue Development Hair Cycle Protein Binding Identical Protein Binding
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