GADD45A and LNX2

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		GADD45A	LNX2
Description		growth arrest and DNA damage inducible alpha	ligand of numb-protein X 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck	Plasma Membrane
	Molecular Function	Protein Binding Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity Promoter-specific Chromatin Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding PDZ Domain Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Apoptotic Process DNA Damage Response Centrosome Cycle Negative Regulation Of Angiogenesis Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Cellular Response To Mechanical Stimulus Cellular Response To Ionizing Radiation Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of P38MAPK Cascade Positive Regulation Of Reactive Oxygen Species Metabolic Process	Nervous System Development Neuron Differentiation Neural Precursor Cell Proliferation
Pathways		TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest FOXO-mediated transcription of cell cycle genes
Drugs
Diseases
GWAS		Bone mineral density (hip) ( 30172743) Mean corpuscular volume ( 29403010) Offspring birth weight ( 31043758) Optic disc area ( 28073927) Optic disc size ( 31809533) Platelet distribution width ( 32888494) Red blood cell count ( 32888494)	Age at first sexual intercourse ( 34211149) Body mass index ( 26426971 28892062) Large B-cell lymphoma ( 21471979) Mean platelet volume ( 27863252 32888494) Night sleep phenotypes ( 27126917) Platelet distribution width ( 27863252 32888494) Response to cytadine analogues (cytosine arabinoside) ( 24483146)
Interacting Genes		69 interacting genes: ADAP1 ASCC2 AURKA BAG6 CBY2 CCNB1 CDK1 CDK11A CDKN1A CENPB CHD3 CLEC3B CNOT9 DCTN2 DNAJC13 EEF1A1 EEF1G ERG28 FAM83D FAS FBN3 FTL GADD45GIP1 GAPDH GBP2 GNB2 H1-1 H2AC16 H2BC21 H3-4 H4C16 IGHM IGSF21 JMJD1C KHSRP LMO4 LNX2 MAP3K4 MAPK14 MASP1 MDM2 MICAL1 MIDN MPP1 NPM1 NRBP1 NUCB2 PARVG PCNA PFKFB4 PPARA PSMC3 PTN PTPRK QARS1 RAI1 RBPJ RPS2 RXRA SH3GLB1 SPTBN4 SYNE4 TLE1 TP53 UBE2D1 UBR1 VIM ZHX1 ZNF135	90 interacting genes: ATP5F1B C10orf88 CABP4 CBX4 CCT3 CDK2 CDK4 CDKN2C CRK CXADR DDA1 DRAP1 EAF2 FANCG FHL3 GADD45A GJD2 GLRX3 GRAP2 GRB2 IGSF5 IL16 INMT IP6K2 L3MBTL2 LGALS14 LNX1 LRRC8E MAP2K5 MAPK9 MCM7 MDGA1 MECOM MLX MRFAP1L1 MSRB3 MYLIP NAGK NMD3 NOTCH1 NTAQ1 NUDT14 NUMB OPTN PARVG PDZRN3 PDZRN4 PEG10 PHYKPL PIK3R1 PIK3R3 PKDREJ POLR1C PPIH PPIL1 PSMD5 PSMF1 PTCD3 RAB6B RBM17 RLIM RNF138 ROPN1 RPA2 SCLY SCNM1 SFN SH3GLB2 SHISA2 SHTN1 SMARCB1 SRSF11 TAB1 TBC1D7 TCL1A TIFA TRAF1 TRAF2 TUBB UBE2D2 UBE2H UBE2I UBE2T UBE2Z USP2 VTN YJU2 ZNF148 ZNF410 ZNF581
Entrez ID		1647	222484
HPRD ID		00528	10042
Ensembl ID		ENSG00000116717	ENSG00000139517
Uniprot IDs		A5JUZ3 P24522	Q8N448
PDB IDs		2KG4	2VWR 5DIN 5E11 5E1Y 5E21 5E22 7QCT
Enriched GO Terms of Interacting Partners?		Cellular Response To UV Response To UV Cellular Response To Light Stimulus Protein Kinase Binding Stress-induced Premature Senescence Molecular Function Activator Activity Nucleoplasm Positive Regulation Of Cardiac Muscle Cell Proliferation Cellular Response To Radiation Regulation Of Heart Growth Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Glucose Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Heart Growth Cyclin B1-CDK1 Complex PCNA-p21 Complex Nucleus Regulation Of Metabolic Process Regulation Of Cardiac Muscle Cell Proliferation Chromatin Organization Structural Constituent Of Chromatin Response To UV-C Regulation Of Growth Negative Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Extracellular Exosome Identical Protein Binding Cytosol Positive Regulation Of Organ Growth Regulation Of Developmental Growth Regulation Of Organ Growth Protein Localization To Organelle Centrosome Cycle Response To Light Stimulus Cellular Response To Actinomycin D Negative Regulation Of Biosynthetic Process Hexose Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Regulation Of Cell Cycle Phase Transition Positive Regulation Of Metabolic Process Cellular Response To Nutrient Levels Protein Binding Nucleosome Assembly Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Actinomycin D	Nucleoplasm Phosphotyrosine Residue Binding Post-translational Protein Modification Nucleus Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Cytosol Ubiquitin-protein Transferase Activity Cellular Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Nuclear Speck Protein Ubiquitination Identical Protein Binding Response To Nitric Oxide Transferase Activity Cytoplasm
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