GADD45A and HIST4H4

Number of citations of the paper that reports this interaction (PMID 10022855)
48

Data Source:
HPRD (in vivo, in vitro)

		GADD45A	HIST4H4
Gene Name		growth arrest and DNA-damage-inducible, alpha	histone cluster 4, H4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Core Promoter Binding Protein Binding	DNA Binding Protein Binding Histone Demethylase Activity (H4-K20 Specific) Poly(A) RNA Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Activation Of MAPKKK Activity DNA Repair Negative Regulation Of Protein Kinase Activity Apoptotic Process Cell Cycle Arrest Centrosome Cycle Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Cellular Response To Mechanical Stimulus Cellular Response To Ionizing Radiation Positive Regulation Of P38MAPK Cascade Positive Regulation Of Reactive Oxygen Species Metabolic Process	Chromatin Silencing At RDNA Mitotic Cell Cycle Telomere Maintenance Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Gene Expression DNA Methylation On Cytosine CENP-A Containing Nucleosome Assembly Histone H4-K20 Demethylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic
Pathways			RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS			Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		65 interactors: ADAP1 ASCC2 AURKA BAG6 C14orf1 CCNB1 CDK1 CDK11A CDKN1A CENPB CHD3 CLEC3B DCTN2 DNAJC13 EEF1A1 EEF1G FAM83D FAS FBN3 FTL GADD45GIP1 GAPDH GBP2 GNB2 HIST1H1A HIST1H2AL HIST2H2BE HIST3H3 HIST4H4 IGHM IGSF21 JMJD1C KHSRP LMO4 MAP3K4 MAPK14 MASP1 MDM2 MICAL1 MIDN MPP1 NPM1 NRBP1 NUCB2 PCNA PFKFB4 PPARA PSMC3 PTN PTPRK QARS RAI1 RBPJ RPS2 RXRA SH3GLB1 SPTBN4 SYNE4 TLE1 TP53 UBE2D1 UBR1 VIM ZHX1 ZNF135	52 interactors: ANP32A ARID4A ASF1A ASF1B BRD2 BRD4 BRD7 CBX5 CDY1 COPRS CREBBP DAXX DNTTIP2 EP300 GADD45A HAT1 HDAC6 HDAC8 HDAC9 ING1 ING2 KAT2A KAT2B KAT6A L3MBTL1 LRWD1 MSL3 NCOA2 NCOA3 NOC2L NSD1 ORC2 ORC3 ORC4 ORC5 PRMT1 PRMT6 RAG1 RPS6KA5 SAP30 SET SETD8 SETDB1 SIAH1 SMARCA5 TAF1A TP53BP1 UBE2I UCHL5 USP16 VHL WDR5
Entrez ID		1647	121504
HPRD ID		00528	13662
Ensembl ID		ENSG00000116717	ENSG00000197837
Uniprot IDs		A5JUZ3 P24522	B2R4R0 P62805
PDB IDs		2KG4	2BQZ 2CV5 2KWN 2KWO 2LVM 2QQS 2RNY 2RS9 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3CFS 3CFV 3F9W 3F9X 3F9Y 3F9Z 3NQJ 3NQU 3O36 3QZS 3QZT 3QZV 3R45 3UVW 3UVX 3UVY 3UW9 3W96 3W97 3W98 3W99 4GQB 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Cell Cycle Cell Cycle Process Regulation Of Gene Expression Mitotic Cell Cycle Mitotic Cell Cycle Process Cellular Response To Organic Substance Regulation Of Protein Metabolic Process Organelle Organization DNA Packaging DNA Conformation Change Negative Regulation Of Cellular Metabolic Process Apoptotic Process Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Cell Aging Protein Complex Assembly Chromatin Organization Negative Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cell Death Death Positive Regulation Of Protein Metabolic Process Cell Cycle Checkpoint Positive Regulation Of Cellular Protein Catabolic Process Response To Organic Substance DNA Damage Checkpoint Chromatin Assembly Or Disassembly Stress-induced Premature Senescence Immune Response Mitotic Cell Cycle Checkpoint Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Gene Expression Mitotic DNA Damage Checkpoint Immune System Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Cell Death Positive Regulation Of Metabolic Process Innate Immune Response Mitotic DNA Integrity Checkpoint Response To Toxic Substance Positive Regulation Of Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Proteolysis Cellular Response To Oxygen Levels	Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Peptidyl-lysine Modification Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Organelle Organization Macromolecule Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Biosynthetic Process Peptidyl-amino Acid Modification Gene Expression RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Chromatin Assembly Or Disassembly Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Assembly Positive Regulation Of Transcription, DNA-templated Histone H3-K9 Modification Histone Methylation Positive Regulation Of Gene Expression Cell Cycle Nucleosome Assembly DNA Packaging
Tagcloud ?		2h5 accompanies anova dynactin gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ube3a ubea5 ubiquinase
Tagcloud (Difference) ?		2h5 accompanies anova dynactin gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ube3a ubea5 ubiquinase
Tagcloud (Intersection) ?