GADD45A and HIST1H2AL

Number of citations of the paper that reports this interaction (PMID 10022855)
48

Data Source:
HPRD (in vivo)

		GADD45A	HIST1H2AL
Gene Name		growth arrest and DNA-damage-inducible, alpha	histone cluster 1, H2al
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleosome Nucleus Extracellular Vesicular Exosome
	Molecular Function	Core Promoter Binding Protein Binding	DNA Binding Protein Binding Enzyme Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Activation Of MAPKKK Activity DNA Repair Negative Regulation Of Protein Kinase Activity Apoptotic Process Cell Cycle Arrest Centrosome Cycle Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Cellular Response To Mechanical Stimulus Cellular Response To Ionizing Radiation Positive Regulation Of P38MAPK Cascade Positive Regulation Of Reactive Oxygen Species Metabolic Process	Biological_process
Pathways			Chromatin modifying enzymes HDACs deacetylate histones Chromatin organization HATs acetylate histones RMTs methylate histone arginines
Drugs
Diseases
GWAS
Protein-Protein Interactions		65 interactors: ADAP1 ASCC2 AURKA BAG6 C14orf1 CCNB1 CDK1 CDK11A CDKN1A CENPB CHD3 CLEC3B DCTN2 DNAJC13 EEF1A1 EEF1G FAM83D FAS FBN3 FTL GADD45GIP1 GAPDH GBP2 GNB2 HIST1H1A HIST1H2AL HIST2H2BE HIST3H3 HIST4H4 IGHM IGSF21 JMJD1C KHSRP LMO4 MAP3K4 MAPK14 MASP1 MDM2 MICAL1 MIDN MPP1 NPM1 NRBP1 NUCB2 PCNA PFKFB4 PPARA PSMC3 PTN PTPRK QARS RAI1 RBPJ RPS2 RXRA SH3GLB1 SPTBN4 SYNE4 TLE1 TP53 UBE2D1 UBR1 VIM ZHX1 ZNF135	5 interactors: BRD7 CRP GADD45A SAP30 TERF2IP
Entrez ID		1647	8332
HPRD ID		00528	09103
Ensembl ID		ENSG00000116717	ENSG00000198374
Uniprot IDs		A5JUZ3 P24522	A4FTV9 P0C0S8
PDB IDs		2KG4
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Cell Cycle Cell Cycle Process Regulation Of Gene Expression Mitotic Cell Cycle Mitotic Cell Cycle Process Cellular Response To Organic Substance Regulation Of Protein Metabolic Process Organelle Organization DNA Packaging DNA Conformation Change Negative Regulation Of Cellular Metabolic Process Apoptotic Process Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Cell Aging Protein Complex Assembly Chromatin Organization Negative Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cell Death Death Positive Regulation Of Protein Metabolic Process Cell Cycle Checkpoint Positive Regulation Of Cellular Protein Catabolic Process Response To Organic Substance DNA Damage Checkpoint Chromatin Assembly Or Disassembly Stress-induced Premature Senescence Immune Response Mitotic Cell Cycle Checkpoint Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Gene Expression Mitotic DNA Damage Checkpoint Immune System Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Cell Death Positive Regulation Of Metabolic Process Innate Immune Response Mitotic DNA Integrity Checkpoint Response To Toxic Substance Positive Regulation Of Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Proteolysis Cellular Response To Oxygen Levels	Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of Cellular Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Chromosome Organization Protection From Non-homologous End Joining At Telomere Telomere Capping Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Vasodilation Activation Of MAPKKK Activity Positive Regulation Of P38MAPK Cascade Positive Regulation Of Superoxide Anion Generation Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Opsonization Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Superoxide Anion Generation Regulation Of Interleukin-8 Secretion Regulation Of P38MAPK Cascade Regulation Of Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Lipid Storage Regulation Of Telomere Maintenance RNA-dependent DNA Replication Positive Regulation Of Histone Acetylation Regulation Of Cellular Component Organization Negative Regulation Of DNA Recombination Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Regulation Of Double-strand Break Repair Nucleobase-containing Compound Metabolic Process Protein Localization To Chromosome Response To Lead Ion Telomere Maintenance Via Telomere Lengthening Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Acute-phase Response Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Vasodilation Regulation Of Histone Acetylation Cellular Response To Calcium Ion Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction
Tagcloud ?		2h5 accompanies anova dynactin gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ube3a ubea5 ubiquinase
Tagcloud (Difference) ?		2h5 accompanies anova dynactin gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ube3a ubea5 ubiquinase
Tagcloud (Intersection) ?