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GADD45A and PFKFB4
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
GADD45A
PFKFB4
Description
growth arrest and DNA damage inducible alpha
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
Cytosol
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex
Molecular Function
Protein Binding
Kinase Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Promoter-specific Chromatin Binding
Nucleotide Binding
Catalytic Activity
6-phosphofructo-2-kinase Activity
Fructose-2,6-bisphosphate 2-phosphatase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Hydrolase Activity
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription By RNA Polymerase II
DNA Repair
Apoptotic Process
DNA Damage Response
Centrosome Cycle
Negative Regulation Of Angiogenesis
Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein
Signal Transduction In Response To DNA Damage
Positive Regulation Of Apoptotic Process
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of JNK Cascade
Regulation Of Cell Cycle
Cellular Response To Mechanical Stimulus
Cellular Response To Ionizing Radiation
Negative Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of P38MAPK Cascade
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Fructose Metabolic Process
Fructose 2,6-bisphosphate Metabolic Process
Gluconeogenesis
Glycolytic Process
Carbohydrate Phosphorylation
Pathways
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
FOXO-mediated transcription of cell cycle genes
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Drugs
Phosphoaminophosphonic Acid-Adenylate Ester
Fructose-6-phosphate
Diseases
GWAS
Bone mineral density (hip) (
30172743
)
Mean corpuscular volume (
29403010
)
Offspring birth weight (
31043758
)
Optic disc area (
28073927
)
Optic disc size (
31809533
)
Platelet distribution width (
32888494
)
Red blood cell count (
32888494
)
Bitter beverage consumption (
31046077
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
23128233
28067908
)
Mental health study participation (completed survey) (
31263887
)
Morning person (
30696823
)
Refractive error (
32231278
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Ulcerative colitis (
25082827
28067908
)
Waist-hip index (
34021172
)
Interacting Genes
69 interacting genes:
ADAP1
ASCC2
AURKA
BAG6
CBY2
CCNB1
CDK1
CDK11A
CDKN1A
CENPB
CHD3
CLEC3B
CNOT9
DCTN2
DNAJC13
EEF1A1
EEF1G
ERG28
FAM83D
FAS
FBN3
FTL
GADD45GIP1
GAPDH
GBP2
GNB2
H1-1
H2AC16
H2BC21
H3-4
H4C16
IGHM
IGSF21
JMJD1C
KHSRP
LMO4
LNX2
MAP3K4
MAPK14
MASP1
MDM2
MICAL1
MIDN
MPP1
NPM1
NRBP1
NUCB2
PARVG
PCNA
PFKFB4
PPARA
PSMC3
PTN
PTPRK
QARS1
RAI1
RBPJ
RPS2
RXRA
SH3GLB1
SPTBN4
SYNE4
TLE1
TP53
UBE2D1
UBR1
VIM
ZHX1
ZNF135
11 interacting genes:
CCDC102B
CDC23
CSNK2B
FBXL7
FBXO28
GADD45A
GSK3B
LRR1
PJA1
THOC3
YBX1
Entrez ID
1647
5210
HPRD ID
00528
05613
Ensembl ID
ENSG00000116717
ENSG00000114268
Uniprot IDs
A5JUZ3
P24522
B7Z5C3
Q16877
Q5XLC3
Q66S35
PDB IDs
2KG4
Enriched GO Terms of Interacting Partners
?
Cellular Response To UV
Response To UV
Cellular Response To Light Stimulus
Protein Kinase Binding
Stress-induced Premature Senescence
Molecular Function Activator Activity
Nucleoplasm
Positive Regulation Of Cardiac Muscle Cell Proliferation
Cellular Response To Radiation
Regulation Of Heart Growth
Regulation Of Cell Cycle G2/M Phase Transition
Regulation Of Primary Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Glucose Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Catalytic Activity
Positive Regulation Of Heart Growth
Cyclin B1-CDK1 Complex
PCNA-p21 Complex
Nucleus
Regulation Of Metabolic Process
Regulation Of Cardiac Muscle Cell Proliferation
Chromatin Organization
Structural Constituent Of Chromatin
Response To UV-C
Regulation Of Growth
Negative Regulation Of Macromolecule Biosynthetic Process
Cyclin-dependent Protein Kinase Holoenzyme Complex
Extracellular Exosome
Identical Protein Binding
Cytosol
Positive Regulation Of Organ Growth
Regulation Of Developmental Growth
Regulation Of Organ Growth
Protein Localization To Organelle
Centrosome Cycle
Response To Light Stimulus
Cellular Response To Actinomycin D
Negative Regulation Of Biosynthetic Process
Hexose Metabolic Process
Regulation Of Macromolecule Metabolic Process
Chromatin Remodeling
Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Metabolic Process
Cellular Response To Nutrient Levels
Protein Binding
Nucleosome Assembly
Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Response To Actinomycin D
Protein Modification Process
Macromolecule Metabolic Process
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Mitotic Cell Cycle Phase Transition
Post-translational Protein Modification
Cell Cycle Phase Transition
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Protein Metabolic Process
Protein Catabolic Process
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Protein Metabolic Process
Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Microtubule Anchoring At Centrosome
Protein Polyubiquitination
Negative Regulation Of Endothelial Cell Migration
Negative Regulation Of Cell Motility
Negative Regulation Of Cell Migration
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Superior Temporal Gyrus Development
Negative Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of Mesenchymal Stem Cell Differentiation
Negative Regulation Of Glycogen (starch) Synthase Activity
Negative Regulation Of Locomotion
Negative Regulation Of Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Kinase CK2 Complex
Symbiont-mediated Disruption Of Host Cell PML Body
MiRNA Transport
Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of TORC2 Signaling
Negative Regulation Of Dopaminergic Neuron Differentiation
Regulation Of Glycogen (starch) Synthase Activity
C5-methylcytidine-containing RNA Reader Activity
Negative Regulation Of Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Activin Receptor Signaling Pathway
Negative Regulation Of Proteolysis
Negative Regulation Of Viral Life Cycle
Release From Viral Latency
Viral Process
Beta-arrestin-dependent Dopamine Receptor Signaling Pathway
Positive Regulation Of Protein Localization To Cilium
Macromolecule Catabolic Process
Proteasomal Protein Catabolic Process
TRNA Transport
Histone Pre-mRNA 3'end Processing Complex
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Tagcloud (Intersection)
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