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GADD45A and PFKFB4
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
GADD45A
PFKFB4
Gene Name
growth arrest and DNA-damage-inducible, alpha
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Molecular Function
Core Promoter Binding
Protein Binding
6-phosphofructo-2-kinase Activity
Fructose-2,6-bisphosphate 2-phosphatase Activity
ATP Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Activation Of MAPKKK Activity
DNA Repair
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Cell Cycle Arrest
Centrosome Cycle
Signal Transduction In Response To DNA Damage
Positive Regulation Of Apoptotic Process
Positive Regulation Of JNK Cascade
Cellular Response To Mechanical Stimulus
Cellular Response To Ionizing Radiation
Positive Regulation Of P38MAPK Cascade
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Carbohydrate Metabolic Process
Fructose Metabolic Process
Fructose 2,6-bisphosphate Metabolic Process
Glucose Metabolic Process
Glycolytic Process
Pathogenesis
Dephosphorylation
Small Molecule Metabolic Process
Carbohydrate Phosphorylation
Pathways
Glucose metabolism
Myoclonic epilepsy of Lafora
Glycogen storage diseases
Glycolysis
Metabolism of carbohydrates
Drugs
Diseases
GWAS
Inflammatory bowel disease (
23128233
)
Protein-Protein Interactions
65 interactors:
ADAP1
ASCC2
AURKA
BAG6
C14orf1
CCNB1
CDK1
CDK11A
CDKN1A
CENPB
CHD3
CLEC3B
DCTN2
DNAJC13
EEF1A1
EEF1G
FAM83D
FAS
FBN3
FTL
GADD45GIP1
GAPDH
GBP2
GNB2
HIST1H1A
HIST1H2AL
HIST2H2BE
HIST3H3
HIST4H4
IGHM
IGSF21
JMJD1C
KHSRP
LMO4
MAP3K4
MAPK14
MASP1
MDM2
MICAL1
MIDN
MPP1
NPM1
NRBP1
NUCB2
PCNA
PFKFB4
PPARA
PSMC3
PTN
PTPRK
QARS
RAI1
RBPJ
RPS2
RXRA
SH3GLB1
SPTBN4
SYNE4
TLE1
TP53
UBE2D1
UBR1
VIM
ZHX1
ZNF135
3 interactors:
CSNK2B
GADD45A
GSK3B
Entrez ID
1647
5210
HPRD ID
00528
05613
Ensembl ID
ENSG00000116717
ENSG00000114268
Uniprot IDs
A5JUZ3
P24522
B7Z5C3
Q16877
Q5XLC2
Q5XLC3
Q66S35
PDB IDs
2KG4
Enriched GO Terms of Interacting Partners
?
Regulation Of Metabolic Process
Cell Cycle
Cell Cycle Process
Regulation Of Gene Expression
Mitotic Cell Cycle
Mitotic Cell Cycle Process
Cellular Response To Organic Substance
Regulation Of Protein Metabolic Process
Organelle Organization
DNA Packaging
DNA Conformation Change
Negative Regulation Of Cellular Metabolic Process
Apoptotic Process
Programmed Cell Death
Regulation Of Cellular Protein Metabolic Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Chromosome Organization
Cell Aging
Protein Complex Assembly
Chromatin Organization
Negative Regulation Of Cell Cycle
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Cell Death
Death
Positive Regulation Of Protein Metabolic Process
Cell Cycle Checkpoint
Positive Regulation Of Cellular Protein Catabolic Process
Response To Organic Substance
DNA Damage Checkpoint
Chromatin Assembly Or Disassembly
Stress-induced Premature Senescence
Immune Response
Mitotic Cell Cycle Checkpoint
Positive Regulation Of Cellular Protein Metabolic Process
Signal Transduction In Response To DNA Damage
Negative Regulation Of Gene Expression
Mitotic DNA Damage Checkpoint
Immune System Process
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Negative Regulation Of Cell Death
Positive Regulation Of Metabolic Process
Innate Immune Response
Mitotic DNA Integrity Checkpoint
Response To Toxic Substance
Positive Regulation Of Cell Cycle
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Mitotic Cell Cycle
Positive Regulation Of Proteolysis
Cellular Response To Oxygen Levels
Cellular Response To Mechanical Stimulus
Positive Regulation Of Protein Phosphorylation
Regulation Of Protein Kinase Activity
Regulation Of Kinase Activity
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Modification Process
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Phosphorylation
Cell Cycle
Negative Regulation Of Type B Pancreatic Cell Development
Superior Temporal Gyrus Development
Negative Regulation Of Protein Kinase Activity
Response To Mechanical Stimulus
Regulation Of Phosphorus Metabolic Process
Negative Regulation Of Kinase Activity
Re-entry Into Mitotic Cell Cycle
Negative Regulation Of Neuron Maturation
Regulation Of Binding
Wnt Signaling Pathway
Hypermethylation Of CpG Island
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process
Response To External Stimulus
Negative Regulation Of Transferase Activity
Negative Regulation Of Protein Phosphorylation
Cellular Response To Interleukin-3
Regulation Of Cellular Protein Metabolic Process
Regulation Of Neuron Maturation
Negative Regulation Of Glycogen (starch) Synthase Activity
Axon Guidance
Regulation Of Protein Metabolic Process
Negative Regulation Of Phosphorylation
Positive Regulation Of Activin Receptor Signaling Pathway
Protein Localization To Microtubule
Adiponectin-activated Signaling Pathway
Activation Of MAPKKK Activity
Positive Regulation Of P38MAPK Cascade
Negative Regulation Of Dendrite Morphogenesis
Regulation Of Catalytic Activity
Negative Regulation Of NFAT Protein Import Into Nucleus
ER Overload Response
Negative Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Glycogen Biosynthetic Process
Endothelial Tube Morphogenesis
Negative Regulation Of Muscle Hypertrophy
Regulation Of Glycogen (starch) Synthase Activity
Axonogenesis
Tagcloud
?
2h5
accompanies
anova
dynactin
gtf2h5
invites
keuls
macaques
malfunctioning
nbn1
ndd
ndds
newman
ovx
perimenopausal
presenilin1
proteosome
psen1
rad23a
raphe
scna
serotonin
speculation
subserving
symptomology
ube2d3
ube3a
ubea5
ubiquinase
Tagcloud (Difference)
?
2h5
accompanies
anova
dynactin
gtf2h5
invites
keuls
macaques
malfunctioning
nbn1
ndd
ndds
newman
ovx
perimenopausal
presenilin1
proteosome
psen1
rad23a
raphe
scna
serotonin
speculation
subserving
symptomology
ube2d3
ube3a
ubea5
ubiquinase
Tagcloud (Intersection)
?