GADD45A and IGHM

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		GADD45A	IGHM
Gene Name		growth arrest and DNA-damage-inducible, alpha	immunoglobulin heavy constant mu
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Extracellular Space Plasma Membrane Cell Surface Integral Component Of Membrane Extracellular Vesicular Exosome Pentameric IgM Immunoglobulin Complex Hexameric IgM Immunoglobulin Complex Blood Microparticle
	Molecular Function	Core Promoter Binding Protein Binding	Single-stranded DNA Binding Antigen Binding Phosphatidylcholine Binding Immunoglobulin Receptor Binding Peptidoglycan Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Activation Of MAPKKK Activity DNA Repair Negative Regulation Of Protein Kinase Activity Apoptotic Process Cell Cycle Arrest Centrosome Cycle Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Cellular Response To Mechanical Stimulus Cellular Response To Ionizing Radiation Positive Regulation Of P38MAPK Cascade Positive Regulation Of Reactive Oxygen Species Metabolic Process	Adaptive Immune Response Antibacterial Humoral Response Innate Immune Response Defense Response To Gram-negative Bacterium
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		65 interactors: ADAP1 ASCC2 AURKA BAG6 C14orf1 CCNB1 CDK1 CDK11A CDKN1A CENPB CHD3 CLEC3B DCTN2 DNAJC13 EEF1A1 EEF1G FAM83D FAS FBN3 FTL GADD45GIP1 GAPDH GBP2 GNB2 HIST1H1A HIST1H2AL HIST2H2BE HIST3H3 HIST4H4 IGHM IGSF21 JMJD1C KHSRP LMO4 MAP3K4 MAPK14 MASP1 MDM2 MICAL1 MIDN MPP1 NPM1 NRBP1 NUCB2 PCNA PFKFB4 PPARA PSMC3 PTN PTPRK QARS RAI1 RBPJ RPS2 RXRA SH3GLB1 SPTBN4 SYNE4 TLE1 TP53 UBE2D1 UBR1 VIM ZHX1 ZNF135	19 interactors: APP CD22 CD79A CEP72 GADD45A GSK3B HPR HSPA5 IGJ MAPKAPK3 PTK2 SH3GL2 SMN1 TK1 UBQLN4 UFD1L VPREB1 VPREB3 ZAK
Entrez ID		1647	3507
HPRD ID		00528	00912
Ensembl ID		ENSG00000116717
Uniprot IDs		A5JUZ3 P24522
PDB IDs		2KG4
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Cell Cycle Cell Cycle Process Regulation Of Gene Expression Mitotic Cell Cycle Mitotic Cell Cycle Process Cellular Response To Organic Substance Regulation Of Protein Metabolic Process Organelle Organization DNA Packaging DNA Conformation Change Negative Regulation Of Cellular Metabolic Process Apoptotic Process Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Cell Aging Protein Complex Assembly Chromatin Organization Negative Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cell Death Death Positive Regulation Of Protein Metabolic Process Cell Cycle Checkpoint Positive Regulation Of Cellular Protein Catabolic Process Response To Organic Substance DNA Damage Checkpoint Chromatin Assembly Or Disassembly Stress-induced Premature Senescence Immune Response Mitotic Cell Cycle Checkpoint Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Gene Expression Mitotic DNA Damage Checkpoint Immune System Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Cell Death Positive Regulation Of Metabolic Process Innate Immune Response Mitotic DNA Integrity Checkpoint Response To Toxic Substance Positive Regulation Of Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Proteolysis Cellular Response To Oxygen Levels	Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Response To External Stimulus Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Positive Regulation Of Phosphorylation ER Overload Response Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Endocytosis Axon Guidance Innate Immune Response Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Signaling Pathway Negative Regulation Of Neuron Differentiation Regulation Of Signal Transduction Vesicle-mediated Transport Platelet Activation Immune System Process Axonogenesis Central Nervous System Development Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Axon Development Regulation Of Signaling Cell Morphogenesis Involved In Neuron Differentiation Cellular Response To Growth Factor Stimulus Cell Death Death Chemotaxis Response To Growth Factor Regulation Of Catalytic Activity Regulation Of Protein Folding In Endoplasmic Reticulum Fetal Process Involved In Parturition Regulation Of MAPK Cascade Neuron Projection Morphogenesis System Development Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Neurogenesis
Tagcloud ?		2h5 accompanies anova dynactin gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ube3a ubea5 ubiquinase	aap aat affymetrix alopecia areata ccl5 cd27 cx3cl1 cxcl10 cxcr5 degs distinctly ereg etiopathogenesis favoring fgf18 fgf5 foxc2 hair hu95a icam2 icam3 ighg3 il7r lck lesional separating sfn v2
Tagcloud (Difference) ?		2h5 accompanies anova dynactin gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ube3a ubea5 ubiquinase	aap aat affymetrix alopecia areata ccl5 cd27 cx3cl1 cxcl10 cxcr5 degs distinctly ereg etiopathogenesis favoring fgf18 fgf5 foxc2 hair hu95a icam2 icam3 ighg3 il7r lck lesional separating sfn v2
Tagcloud (Intersection) ?