GADD45A and PTPRK

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GADD45A	PTPRK
Gene Name		growth arrest and DNA-damage-inducible, alpha	protein tyrosine phosphatase, receptor type, K
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Photoreceptor Outer Segment Integral Component Of Plasma Membrane Cell-cell Junction Adherens Junction Cell Surface Integral Component Of Membrane Axon Dendrite Leading Edge Membrane Neuronal Cell Body
	Molecular Function	Core Promoter Binding Protein Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding Protein Kinase Binding Gamma-catenin Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Activation Of MAPKKK Activity DNA Repair Negative Regulation Of Protein Kinase Activity Apoptotic Process Cell Cycle Arrest Centrosome Cycle Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Cellular Response To Mechanical Stimulus Cellular Response To Ionizing Radiation Positive Regulation Of P38MAPK Cascade Positive Regulation Of Reactive Oxygen Species Metabolic Process	Protein Dephosphorylation Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Keratinocyte Proliferation Cell Migration Negative Regulation Of Cell Migration Protein Localization To Cell Surface Cellular Response To Reactive Oxygen Species Cellular Response To UV Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Focal Adhesion Assembly
Pathways
Drugs
Diseases
GWAS			Celiac disease ( 20190752) Multiple sclerosis ( 21833088)
Protein-Protein Interactions		65 interactors: ADAP1 ASCC2 AURKA BAG6 C14orf1 CCNB1 CDK1 CDK11A CDKN1A CENPB CHD3 CLEC3B DCTN2 DNAJC13 EEF1A1 EEF1G FAM83D FAS FBN3 FTL GADD45GIP1 GAPDH GBP2 GNB2 HIST1H1A HIST1H2AL HIST2H2BE HIST3H3 HIST4H4 IGHM IGSF21 JMJD1C KHSRP LMO4 MAP3K4 MAPK14 MASP1 MDM2 MICAL1 MIDN MPP1 NPM1 NRBP1 NUCB2 PCNA PFKFB4 PPARA PSMC3 PTN PTPRK QARS RAI1 RBPJ RPS2 RXRA SH3GLB1 SPTBN4 SYNE4 TLE1 TP53 UBE2D1 UBR1 VIM ZHX1 ZNF135	8 interactors: CSNK2B CTNNB1 GADD45A GADD45G JUP PSMD11 PTPRM TK1
Entrez ID		1647	5796
HPRD ID		00528	03968
Ensembl ID		ENSG00000116717	ENSG00000152894
Uniprot IDs		A5JUZ3 P24522	B4DHC3 B7ZMG0 Q15262 Q59EZ1 Q5TG12 Q86WJ2
PDB IDs		2KG4	2C7S
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Cell Cycle Cell Cycle Process Regulation Of Gene Expression Mitotic Cell Cycle Mitotic Cell Cycle Process Cellular Response To Organic Substance Regulation Of Protein Metabolic Process Organelle Organization DNA Packaging DNA Conformation Change Negative Regulation Of Cellular Metabolic Process Apoptotic Process Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Cell Aging Protein Complex Assembly Chromatin Organization Negative Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cell Death Death Positive Regulation Of Protein Metabolic Process Cell Cycle Checkpoint Positive Regulation Of Cellular Protein Catabolic Process Response To Organic Substance DNA Damage Checkpoint Chromatin Assembly Or Disassembly Stress-induced Premature Senescence Immune Response Mitotic Cell Cycle Checkpoint Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Gene Expression Mitotic DNA Damage Checkpoint Immune System Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Cell Death Positive Regulation Of Metabolic Process Innate Immune Response Mitotic DNA Integrity Checkpoint Response To Toxic Substance Positive Regulation Of Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Proteolysis Cellular Response To Oxygen Levels	Positive Regulation Of Signal Transduction Cellular Response To Indole-3-methanol Activation Of MAPKKK Activity Positive Regulation Of P38MAPK Cascade Positive Regulation Of Protein Modification Process Response To External Stimulus Endothelial Tube Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Protein Complex Assembly Regulation Of P38MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Wnt Signaling Pathway Regulation Of Cell Fate Specification Positive Regulation Of Protein Metabolic Process Response To Mechanical Stimulus Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Fate Commitment Regulation Of Signal Transduction Negative Regulation Of Endothelial Cell Migration Adherens Junction Assembly Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Negative Regulation Of Transferase Activity Regulation Of Signaling Regulation Of Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Cellular Component Assembly Centrosome Cycle Apoptotic Process Regulation Of Cellular Protein Metabolic Process Programmed Cell Death Response To Stimulus Developmental Process Cell Death Cellular Response To Mechanical Stimulus Death Regulation Of Protein Metabolic Process Protein Oligomerization Adherens Junction Organization Positive Regulation Of MAPK Cascade Fetal Process Involved In Parturition Negative Regulation Of Cell Cycle Endothelium Development Signal Transduction In Response To DNA Damage Locomotion Centrosome Organization Regulation Of Phosphorylation Regulation Of Endothelial Cell Migration
Tagcloud ?		2h5 accompanies anova dynactin gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ube3a ubea5 ubiquinase	activating beta1 concert contact dephosphorylates egfr importantly interestingly interplay jag1 jagged kappa keratinocyte keratinocytes ligand limiting notch notch1 phosphatase responsive sb431542 secretase smad3 sparse stimulate substantially suppresses tgf thereby
Tagcloud (Difference) ?		2h5 accompanies anova dynactin gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ube3a ubea5 ubiquinase	activating beta1 concert contact dephosphorylates egfr importantly interestingly interplay jag1 jagged kappa keratinocyte keratinocytes ligand limiting notch notch1 phosphatase responsive sb431542 secretase smad3 sparse stimulate substantially suppresses tgf thereby
Tagcloud (Intersection) ?