GADD45A and PTPRK

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GADD45A	PTPRK
Description		growth arrest and DNA damage inducible alpha	protein tyrosine phosphatase receptor type K
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck	Plasma Membrane Cell-cell Junction Adherens Junction Cell Surface Membrane Cell Junction Leading Edge Membrane Anchoring Junction
	Molecular Function	Protein Binding Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity Promoter-specific Chromatin Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding Hydrolase Activity Protein Kinase Binding Gamma-catenin Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Apoptotic Process DNA Damage Response Centrosome Cycle Negative Regulation Of Angiogenesis Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Cellular Response To Mechanical Stimulus Cellular Response To Ionizing Radiation Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of P38MAPK Cascade Positive Regulation Of Reactive Oxygen Species Metabolic Process	Protein Dephosphorylation Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Negative Regulation Of Keratinocyte Proliferation Cell Migration Negative Regulation Of Cell Migration Neuron Projection Development Protein Localization To Cell Surface Cellular Response To Reactive Oxygen Species Cellular Response To UV Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Focal Adhesion Assembly
Pathways		TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest FOXO-mediated transcription of cell cycle genes	EGFR downregulation
Drugs
Diseases
GWAS		Bone mineral density (hip) ( 30172743) Mean corpuscular volume ( 29403010) Offspring birth weight ( 31043758) Optic disc area ( 28073927) Optic disc size ( 31809533) Platelet distribution width ( 32888494) Red blood cell count ( 32888494)	Adiponectin levels ( 33562295) Allergic disease (asthma, hay fever or eczema) ( 29083406) Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Asthma ( 31959851 31619474 31361310 30929738 32296059 34103634) Asthma (childhood onset) ( 30929738) Celiac disease ( 30572963 22057235 20190752) Crohn's disease ( 28067908) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Hodgkin's lymphoma ( 29196614) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Multiple sclerosis ( 21833088) Nodular sclerosis Hodgkin lymphoma ( 29196614) Reaction time ( 29844566) Uterine fibroid size (maximum volume) ( 30196971) Waist circumference ( 28552196)
Interacting Genes		69 interacting genes: ADAP1 ASCC2 AURKA BAG6 CBY2 CCNB1 CDK1 CDK11A CDKN1A CENPB CHD3 CLEC3B CNOT9 DCTN2 DNAJC13 EEF1A1 EEF1G ERG28 FAM83D FAS FBN3 FTL GADD45GIP1 GAPDH GBP2 GNB2 H1-1 H2AC16 H2BC21 H3-4 H4C16 IGHM IGSF21 JMJD1C KHSRP LMO4 LNX2 MAP3K4 MAPK14 MASP1 MDM2 MICAL1 MIDN MPP1 NPM1 NRBP1 NUCB2 PARVG PCNA PFKFB4 PPARA PSMC3 PTN PTPRK QARS1 RAI1 RBPJ RPS2 RXRA SH3GLB1 SPTBN4 SYNE4 TLE1 TP53 UBE2D1 UBR1 VIM ZHX1 ZNF135	9 interacting genes: CSNK2B CTNNB1 GADD45A GADD45G JUP PSMD11 PTPRM RIPK4 TK1
Entrez ID		1647	5796
HPRD ID		00528	03968
Ensembl ID		ENSG00000116717	ENSG00000152894
Uniprot IDs		A5JUZ3 P24522	B4DHC3 Q15262 Q59EZ1 Q86WJ2
PDB IDs		2KG4	2C7S 8A1F
Enriched GO Terms of Interacting Partners?		Cellular Response To UV Response To UV Cellular Response To Light Stimulus Protein Kinase Binding Stress-induced Premature Senescence Molecular Function Activator Activity Nucleoplasm Positive Regulation Of Cardiac Muscle Cell Proliferation Cellular Response To Radiation Regulation Of Heart Growth Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Glucose Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Heart Growth Cyclin B1-CDK1 Complex PCNA-p21 Complex Nucleus Regulation Of Metabolic Process Regulation Of Cardiac Muscle Cell Proliferation Chromatin Organization Structural Constituent Of Chromatin Response To UV-C Regulation Of Growth Negative Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Extracellular Exosome Identical Protein Binding Cytosol Positive Regulation Of Organ Growth Regulation Of Developmental Growth Regulation Of Organ Growth Protein Localization To Organelle Centrosome Cycle Response To Light Stimulus Cellular Response To Actinomycin D Negative Regulation Of Biosynthetic Process Hexose Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Regulation Of Cell Cycle Phase Transition Positive Regulation Of Metabolic Process Cellular Response To Nutrient Levels Protein Binding Nucleosome Assembly Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Actinomycin D	Negative Regulation Of Endothelial Cell Migration Catenin-TCF7L2 Complex Regulation Of Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Cellular Response To Indole-3-methanol Skin Development Response To Indole-3-methanol Negative Regulation Of Cell Migration Endothelial Tube Morphogenesis Regulation Of Vasculature Development Alpha-catenin Binding Regulation Of Angiogenesis Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Blood Vessel Endothelial Cell Migration Ficolin-1-rich Granule Lumen Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Positive Regulation Of P38MAPK Cascade Catenin Complex Adherens Junction Response To Mechanical Stimulus Cell-cell Junction Regulation Of P38MAPK Cascade Detection Of Mechanical Stimulus Protein-DNA Complex Nuclear Receptor Binding Intercalated Disc Wnt Signaling Pathway Cytoplasm Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Cadherin Binding Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Gamma-catenin-TCF7L2 Complex Morphogenesis Of An Epithelium Positive Regulation Of Signal Transduction Regulation Of Anatomical Structure Morphogenesis Regulation Of Cell Migration Positive Regulation Of Cell Communication Positive Regulation Of Signaling Tissue Morphogenesis Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Renal Outer Medulla Development
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