SYNE4 and KLHL12

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SYNE4	KLHL12
Gene Name		spectrin repeat containing, nuclear envelope family member 4	kelch-like family member 12
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Nuclear Outer Membrane LINC Complex	Golgi Membrane Cytosol ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex
	Molecular Function		Protein Binding
	Biological Process	Establishment Of Epithelial Cell Apical/basal Polarity	Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Wnt Signaling Pathway COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		52 interactors: ABT1 ADIPOQ BRICD5 C10orf35 C3orf52 CD47 CEP19 CLDN7 CLDN8 CLEC7A CMTM5 CSGALNACT2 CSNK2B CXCL9 DEFB121 ECE2 EDDM3B EMP1 ENTPD3 FATE1 GADD45A GSK3B ITM2B KLC4 KLHL12 KLRG1 KTN1 MALL MARCH2 NAGK OCLN OLFM4 OSTCP1 PAQR5 RIPPLY2 RPS6KA6 SEC22A SEC23B SENP2 SFTPC SLN SMCO4 TMEM115 TMEM140 TMEM147 TMEM182 TMEM248 TMPRSS4 TRIM69 TSPAN15 VTI1B ZNF250	39 interactors: ARAF ATXN1 BAG6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CUL3 DGCR6 DRD4 DVL3 FGD2 FLNA GLYCTK INMT KLHL2 KLHL3 LNX1 MED28 MPP1 MRPL10 NDC80 PDGFRB PEF1 PRR13 RIT1 RPP25L SDCBP SNX20 SYNE4 TAOK2 TBC1D10C TTBK2 UBE2I VEGFB VTA1 WDYHV1 ZBP1
Entrez ID		163183	59349
HPRD ID		08776	13925
Ensembl ID		ENSG00000181392	ENSG00000117153
Uniprot IDs		Q8N205	Q53G59
PDB IDs			2VPJ
Enriched GO Terms of Interacting Partners?		ER To Golgi Vesicle-mediated Transport Negative Regulation Of Binding Regulation Of Binding Golgi Vesicle Transport Adiponectin-activated Signaling Pathway Vesicle Fusion With Golgi Apparatus Negative Regulation Of Protein Binding Response To External Stimulus Regulation Of Glycogen (starch) Synthase Activity Cellular Response To Mechanical Stimulus Vesicle-mediated Transport Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Intracellular Signal Transduction	Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Component Assembly Positive Regulation Of Transferase Activity Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Kinase Activity Coronary Vasculature Development Actin Cytoskeleton Organization Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Metabolic Process Intracellular Signal Transduction Chromosome Segregation Actin Filament-based Process Positive Regulation Of Catalytic Activity Anatomical Structure Development Cellular Protein Modification Process Activation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Ubiquitin-dependent Protein Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Modification-dependent Protein Catabolic Process Cell Projection Assembly Regulation Of MAP Kinase Activity Positive Regulation Of Cell Division Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Chemotaxis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division
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