SYNE4 and TSPAN15

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SYNE4	TSPAN15
Gene Name		spectrin repeat containing, nuclear envelope family member 4	tetraspanin 15
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Nuclear Outer Membrane LINC Complex	Plasma Membrane Cell Surface Integral Component Of Membrane Extracellular Vesicular Exosome Tetraspanin-enriched Microdomain
	Molecular Function		Enzyme Binding
	Biological Process	Establishment Of Epithelial Cell Apical/basal Polarity	Regulation Of Notch Signaling Pathway Protein Maturation Establishment Of Protein Localization To Plasma Membrane
Pathways
Drugs
Diseases
GWAS			Response to taxane treatment (placlitaxel) ( 23006423)
Protein-Protein Interactions		52 interactors: ABT1 ADIPOQ BRICD5 C10orf35 C3orf52 CD47 CEP19 CLDN7 CLDN8 CLEC7A CMTM5 CSGALNACT2 CSNK2B CXCL9 DEFB121 ECE2 EDDM3B EMP1 ENTPD3 FATE1 GADD45A GSK3B ITM2B KLC4 KLHL12 KLRG1 KTN1 MALL MARCH2 NAGK OCLN OLFM4 OSTCP1 PAQR5 RIPPLY2 RPS6KA6 SEC22A SEC23B SENP2 SFTPC SLN SMCO4 TMEM115 TMEM140 TMEM147 TMEM182 TMEM248 TMPRSS4 TRIM69 TSPAN15 VTI1B ZNF250	3 interactors: BTRC RGS2 SYNE4
Entrez ID		163183	23555
HPRD ID		08776	15511
Ensembl ID		ENSG00000181392	ENSG00000099282
Uniprot IDs		Q8N205	O95858
PDB IDs
Enriched GO Terms of Interacting Partners?		ER To Golgi Vesicle-mediated Transport Negative Regulation Of Binding Regulation Of Binding Golgi Vesicle Transport Adiponectin-activated Signaling Pathway Vesicle Fusion With Golgi Apparatus Negative Regulation Of Protein Binding Response To External Stimulus Regulation Of Glycogen (starch) Synthase Activity Cellular Response To Mechanical Stimulus Vesicle-mediated Transport Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Intracellular Signal Transduction	Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Adrenergic Receptor Signaling Pathway Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of CAMP-mediated Signaling Establishment Of Apical/basal Cell Polarity Negative Regulation Of Phospholipase Activity Polarized Epithelial Cell Differentiation Posttranscriptional Regulation Of Gene Expression Relaxation Of Vascular Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Relaxation Of Smooth Muscle Establishment Of Monopolar Cell Polarity Negative Regulation Of Muscle Hypertrophy Positive Regulation Of Striated Muscle Contraction Morphogenesis Of An Epithelium Positive Regulation Of Microtubule Polymerization Relaxation Of Cardiac Muscle Negative Regulation Of Smooth Muscle Contraction Establishment Of Epithelial Cell Polarity Tissue Morphogenesis Positive Regulation Of Circadian Rhythm Negative Regulation Of Lipase Activity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Muscle Contraction Regulation Of CAMP-mediated Signaling Relaxation Of Muscle Morphogenesis Of A Polarized Epithelium SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Heart Contraction Regulation Of Microtubule Polymerization Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Smoothened Signaling Pathway Vasodilation Brown Fat Cell Differentiation Epithelium Development Branching Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Signal Transduction Regulation Of Smooth Muscle Contraction Negative Regulation Of Signaling Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Mammary Gland Duct Morphogenesis Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Microtubule Polymerization Or Depolymerization
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