SYNE4 and DEFB121

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SYNE4	DEFB121
Description		spectrin repeat containing nuclear envelope family member 4	defensin beta 121
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Outer Membrane Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex	Extracellular Region
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Establishment Of Epithelial Cell Apical/basal Polarity	Defense Response Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium
Pathways			Beta defensins Defensins
Drugs
Diseases
GWAS			Liver enzyme levels (alkaline phosphatase) ( 33972514) Prudent dietary pattern ( 28644415)
Interacting Genes		56 interacting genes: ABT1 ADIPOQ BRICD5 C3orf52 CD47 CEP19 CFTR CLDN19 CLDN7 CLDN8 CLEC7A CMTM5 CSNK2B CXCL9 DEFB121 ECE2 EDDM3B EMP1 ENTPD3 FAM241B FATE1 GADD45A GSK3B IGFBP5 ITM2B KLHL12 KLRG1 KTN1 MALL MARCHF2 NAGK OCLN OLFM4 OSTCP1 PAQR5 PLPP6 RIPPLY2 RPS6KA6 SEC22A SEC23B SENP2 SFTPC SLN SMCO4 TCEA2 TMEM115 TMEM140 TMEM147 TMEM182 TMEM248 TMPRSS4 TRIM69 TSPAN15 VTI1B ZNF250 ZNF648	10 interacting genes: CD40 CLEC2D FAM209A GJA8 IL27RA LAYN LRRC25 NECTIN4 SSMEM1 SYNE4
Entrez ID		163183	245934
HPRD ID		08776	16791
Ensembl ID		ENSG00000181392	ENSG00000204548
Uniprot IDs		Q8N205	A0A384MDM0 Q5GRF9 Q5J5C9
PDB IDs		6R16 6WMD
Enriched GO Terms of Interacting Partners?		Protein Binding Bicellular Tight Junction Assembly Tight Junction Organization Tight Junction Assembly Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Apicolateral Plasma Membrane Regulation Of Glycogen (starch) Synthase Activity	Regulation Of Isotype Switching To IgG Isotypes Regulation Of Isotype Switching Regulation Of Lymphocyte Mediated Immunity Membrane Negative Regulation Of T Cell Extravasation Regulation Of Immunoglobulin Production Interleukin-27 Receptor Activity Positive Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Response To Cobalamin
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