SYNE4 and OCLN

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		SYNE4	OCLN
Description		spectrin repeat containing nuclear envelope family member 4	occludin
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Outer Membrane Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex	Lysosomal Membrane Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Cell Junction Endocytic Vesicle Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Tight Junction Anchoring Junction
	Molecular Function	Protein Binding	Protein Binding Protein Domain Specific Binding
	Biological Process	Establishment Of Epithelial Cell Apical/basal Polarity	Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Epithelial Cell Migration Regulation Of D-glucose Transmembrane Transport Positive Regulation Of Microtubule Polymerization Maintenance Of Blood-brain Barrier Cell-cell Junction Organization Positive Regulation Of D-glucose Import Protein-containing Complex Assembly Bicellular Tight Junction Assembly Positive Regulation Of Wound Healing Tight Junction Organization Protein Localization To Cell Leading Edge Positive Regulation Of Blood-brain Barrier Permeability
Pathways			Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions
Drugs
Diseases			Band-like calcification with simplified gyration and polymicrogyria (BLC-PMG); Pseudo-TORCH syndrome
GWAS			Hand grip strength (Mahalanobis distance) ( 32235003) Interleukin-18 levels ( 27989323)
Interacting Genes		56 interacting genes: ABT1 ADIPOQ BRICD5 C3orf52 CD47 CEP19 CFTR CLDN19 CLDN7 CLDN8 CLEC7A CMTM5 CSNK2B CXCL9 DEFB121 ECE2 EDDM3B EMP1 ENTPD3 FAM241B FATE1 GADD45A GSK3B IGFBP5 ITM2B KLHL12 KLRG1 KTN1 MALL MARCHF2 NAGK OCLN OLFM4 OSTCP1 PAQR5 PLPP6 RIPPLY2 RPS6KA6 SEC22A SEC23B SENP2 SFTPC SLN SMCO4 TCEA2 TMEM115 TMEM140 TMEM147 TMEM182 TMEM248 TMPRSS4 TRIM69 TSPAN15 VTI1B ZNF250 ZNF648	12 interacting genes: CLEC7A CSNK1A1 CSNK2A1 FATE1 GPX8 OGT PTPN2 SNW1 SYNE4 TNFAIP3 ULK1 USP40
Entrez ID		163183	100506658
HPRD ID		08776
Ensembl ID		ENSG00000181392	ENSG00000197822
Uniprot IDs		Q8N205	A0A0G2JMZ8 A8K3T2 Q16625
PDB IDs		6R16 6WMD	1WPA 1XAW 3G7C
Enriched GO Terms of Interacting Partners?		Protein Binding Bicellular Tight Junction Assembly Tight Junction Organization Tight Junction Assembly Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Apicolateral Plasma Membrane Regulation Of Glycogen (starch) Synthase Activity	Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Protein Catabolic Process Positive Regulation Of Signaling Negative Regulation Of Protein-containing Complex Assembly Sin3-type Complex Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Protein-containing Complex Assembly Macroautophagy Protein Modification Process Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Cellular Response To Nutrient Positive Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Cellular Response To Nutrient Levels Regulation Of Signaling Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Gluconeogenesis Negative Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Interleukin-2-mediated Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Tolerance Induction To Lipopolysaccharide Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Mitophagy Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Detection Of Yeast Detection Of Molecule Of Fungal Origin TORC1 Signaling Proteolysis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Establishment Of Protein Localization To Vacuole Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Interleukin-2 Production Positive Regulation Of TORC1 Signaling Autophagy Organelle Assembly Regulation Of Insulin Receptor Signaling Pathway Autophagy Of Mitochondrion
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