SYNE4 and SLN

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SYNE4	SLN
Description		spectrin repeat containing nuclear envelope family member 4	sarcolipin
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Outer Membrane Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Sarcoplasmic Reticulum Membrane
	Molecular Function	Protein Binding	Enzyme Inhibitor Activity Protein Binding Enzyme Regulator Activity ATPase Binding
	Biological Process	Establishment Of Epithelial Cell Apical/basal Polarity	Calcium Ion Transport Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Calcium Ion Transport Sarcoplasmic Reticulum Calcium Ion Transport Negative Regulation Of Calcium Ion Import Positive Regulation Of Cold-induced Thermogenesis Regulation Of Relaxation Of Muscle Positive Regulation Of Protein Depolymerization Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum
Pathways			Ion homeostasis Ion transport by P-type ATPases
Drugs
Diseases
GWAS
Interacting Genes		56 interacting genes: ABT1 ADIPOQ BRICD5 C3orf52 CD47 CEP19 CFTR CLDN19 CLDN7 CLDN8 CLEC7A CMTM5 CSNK2B CXCL9 DEFB121 ECE2 EDDM3B EMP1 ENTPD3 FAM241B FATE1 GADD45A GSK3B IGFBP5 ITM2B KLHL12 KLRG1 KTN1 MALL MARCHF2 NAGK OCLN OLFM4 OSTCP1 PAQR5 PLPP6 RIPPLY2 RPS6KA6 SEC22A SEC23B SENP2 SFTPC SLN SMCO4 TCEA2 TMEM115 TMEM140 TMEM147 TMEM182 TMEM248 TMPRSS4 TRIM69 TSPAN15 VTI1B ZNF250 ZNF648	7 interacting genes: ATP2A1 KASH5 LMNA PLN PTPN11 SYNE4 TMEM79
Entrez ID		163183	6588
HPRD ID		08776	03729
Ensembl ID		ENSG00000181392	ENSG00000170290
Uniprot IDs		Q8N205	A0A158RFT9 O00631
PDB IDs		6R16 6WMD	1JDM
Enriched GO Terms of Interacting Partners?		Protein Binding Bicellular Tight Junction Assembly Tight Junction Organization Tight Junction Assembly Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Apicolateral Plasma Membrane Regulation Of Glycogen (starch) Synthase Activity	Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Meiotic Nuclear Membrane Microtubule Tethering Complex Relaxation Of Muscle Regulation Of Cardiac Muscle Cell Contraction Regulation Of ATP-dependent Activity Regulation Of System Process Nuclear Envelope Nuclear Outer Membrane Sarcoplasmic Reticulum Membrane Regulation Of Muscle System Process Regulation Of Intracellular Transport Maintenance Of Mitochondrion Location Calcium-dependent ATPase Activity Sarcoplasmic Reticulum Regulation Of Transmembrane Transporter Activity Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Relaxation Of Skeletal Muscle H Zone Regulation Of Cardiac Muscle Contraction Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction Regulation Of Striated Muscle Contraction Regulation Of Monoatomic Ion Transmembrane Transporter Activity DNA Double-strand Break Attachment To Nuclear Envelope Chromosome Localization Structural Constituent Of Nuclear Lamina Regulation Of The Force Of Heart Contraction By Cardiac Conduction Calcium Ion-transporting ATPase Complex Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Intestinal Epithelial Cell Migration Meiotic Spindle Pole Organelle Localization Developmental Process Negative Regulation Of Multicellular Organismal Process Calcium Ion Import Into Sarcoplasmic Reticulum Regulation Of Cellular Localization Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Cerebellar Cortex Formation Cuticle Development Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Circadian Sleep/wake Cycle Process Negative Regulation Of Glucocorticoid Secretion Anterior Head Development
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