SYNE4 and RPS6KA6

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		SYNE4	RPS6KA6
Gene Name		spectrin repeat containing, nuclear envelope family member 4	ribosomal protein S6 kinase, 90kDa, polypeptide 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Nuclear Outer Membrane LINC Complex	Nucleus Nucleoplasm Nucleolus Mitochondrion Cytosol
	Molecular Function		Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding
	Biological Process	Establishment Of Epithelial Cell Apical/basal Polarity	Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction Synaptic Transmission Axon Guidance Central Nervous System Development Negative Regulation Of Embryonic Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Mesoderm Development
Pathways			Axon guidance RSK activation Activation of NMDA receptor upon glutamate binding and postsynaptic events L1CAM interactions Recycling pathway of L1 CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses Post NMDA receptor activation events
Drugs
Diseases
GWAS
Protein-Protein Interactions		52 interactors: ABT1 ADIPOQ BRICD5 C10orf35 C3orf52 CD47 CEP19 CLDN7 CLDN8 CLEC7A CMTM5 CSGALNACT2 CSNK2B CXCL9 DEFB121 ECE2 EDDM3B EMP1 ENTPD3 FATE1 GADD45A GSK3B ITM2B KLC4 KLHL12 KLRG1 KTN1 MALL MARCH2 NAGK OCLN OLFM4 OSTCP1 PAQR5 RIPPLY2 RPS6KA6 SEC22A SEC23B SENP2 SFTPC SLN SMCO4 TMEM115 TMEM140 TMEM147 TMEM182 TMEM248 TMPRSS4 TRIM69 TSPAN15 VTI1B ZNF250	28 interactors: ADIRF APP C14orf1 CEBPZ CENPB CLEC3B DHX34 DNAJC13 DNMT1 FBN3 FZD5 LMO4 MAPK3 MASP1 MED24 MICAL1 MPP1 NR4A1 RBPJ RPLP1 RXRA SAP30BP SPTBN4 SYNE4 UBE2I UFM1 ZNF227 ZNF746
Entrez ID		163183	27330
HPRD ID		08776	02250
Ensembl ID		ENSG00000181392
Uniprot IDs		Q8N205	Q9UK32
PDB IDs
Enriched GO Terms of Interacting Partners?		ER To Golgi Vesicle-mediated Transport Negative Regulation Of Binding Regulation Of Binding Golgi Vesicle Transport Adiponectin-activated Signaling Pathway Vesicle Fusion With Golgi Apparatus Negative Regulation Of Protein Binding Response To External Stimulus Regulation Of Glycogen (starch) Synthase Activity Cellular Response To Mechanical Stimulus Vesicle-mediated Transport Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Intracellular Signal Transduction	Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Gene Expression Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process DNA-templated Transcription, Initiation Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Protein Processing Regulation Of Early Endosome To Late Endosome Transport Cell Differentiation Biosynthetic Process Cardiac Ventricle Development Negative Regulation Of Cellular Metabolic Process Labyrinthine Layer Blood Vessel Development Sterol Metabolic Process Tissue Development Cardiac Chamber Development Neuron Maturation Regulation Of Cell Fate Commitment Apoptotic Process Cell Maturation Negative Regulation Of Protein Processing Regulation Of Cellular Process Tissue Morphogenesis Programmed Cell Death Placenta Blood Vessel Development
Tagcloud ?			anchorage anticipated attribution azacytidine cdna chemoresponse clines codons deleted demethylation depended duplet encompass exclude exon immunoblots indolocarbazole isoforms nt nucleotides penultimate rsk4 situation sparse splice starvation suppressive triplet uncharacterized
Tagcloud (Difference) ?			anchorage anticipated attribution azacytidine cdna chemoresponse clines codons deleted demethylation depended duplet encompass exclude exon immunoblots indolocarbazole isoforms nt nucleotides penultimate rsk4 situation sparse splice starvation suppressive triplet uncharacterized
Tagcloud (Intersection) ?