MKRN3 and MNAT1

Number of citations of the paper that reports this interaction (PMID 22493164)
2

Data Source:
BioGRID (two hybrid)

		MKRN3	MNAT1
Gene Name		makorin ring finger protein 3	MNAT CDK-activating kinase assembly factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ribonucleoprotein Complex	Nucleoplasm Holo TFIIH Complex Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Ligase Activity	Protein Binding DNA-dependent ATPase Activity Zinc Ion Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity Protein N-terminus Binding
	Biological Process	Protein Ubiquitination	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Complex Assembly Protein Phosphorylation Adult Heart Development Cell Proliferation Gene Expression Viral Process Ventricular System Development Regulation Of Gene Expression, Epigenetic Negative Regulation Of Apoptotic Process Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Viral Transcription Response To Calcium Ion
Pathways			RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Tat-mediated elongation of the HIV-1 transcript Cyclin E associated events during G1/S transition Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression G1/S Transition Mitotic G1-G1/S phases S Phase Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Cyclin A:Cdk2-associated events at S phase entry Mitotic G2-G2/M phases Transcription of the HIV genome Nucleotide Excision Repair RNA Polymerase II Transcription RNA Polymerase I Transcription Initiation HIV Infection RNA Polymerase I Promoter Clearance Formation of the Early Elongation Complex G2/M Transition RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Cyclin A/B1 associated events during G2/M transition RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER RNA Polymerase I Transcription mRNA Capping RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination G1 Phase Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Cell Cycle, Mitotic Cyclin D associated events in G1 Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Protein-Protein Interactions		55 interactors: ANKRD11 BEX2 CRACR2A ENKD1 ERCC1 FAM110A FAM124B FARS2 KIF1A LRSAM1 MDM2 MDM4 MEOX2 MNAT1 MRPS6 NABP1 NDE1 PEX10 PEX5 PRPF31 PSMA1 RBM41 RNF166 RNF32 RNF7 SCNM1 SF1 SFN TCEA2 TCHP TFAP2A TRIM23 TRIM31 TRIM34 TRIM5 TRIM65 TRIM8 TSG101 TTC25 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2L3 UBE2N UBE2U UBE2V1 UBE2V2 UBE2W	42 interactors: BRCA1 CCNH CDK7 COPS6 CTD DMAP1 E2F1 EEF1A1 ERCC3 ESR1 GTF2E2 HPS6 LRIF1 MBP MCM7 MDM4 MKRN3 MTA1 NGFRAP1 NKX3-1 POLR2A POU2F1 POU2F2 POU5F1 RB1 RBM48 RNF32 RNF41 RNF7 SUPT5H TP53 TRIM17 TRIM2 TRIM21 TRIM26 TRIM31 TRIM34 TRIM39 TRIM5 TRIM9 TRIML1 USP2
Entrez ID		7681	4331
HPRD ID		04836	04042
Ensembl ID		ENSG00000179455	ENSG00000020426
Uniprot IDs		Q13064	P51948
PDB IDs			1G25
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cellular Macromolecule Catabolic Process Protein K63-linked Ubiquitination Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Cellular Response To Stress Catabolic Process Cellular Response To DNA Damage Stimulus Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Metabolic Process Response To Stress Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Ubiquitin-protein Transferase Activity Activation Of Innate Immune Response Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Proteolysis Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Cycle Cellular Response To Hypoxia Positive Regulation Of Innate Immune Response Cellular Response To Decreased Oxygen Levels DNA Repair Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell Cycle Process Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Protein Ubiquitination Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Innate Immune Response Regulation Of Viral Entry Into Host Cell Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Catabolic Process Viral Process	Regulation Of Transcription, DNA-templated Regulation Of Viral Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Viral Transcription Protein Ubiquitination Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Protein Modification By Small Protein Conjugation Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Positive Regulation Of Viral Process 7-methylguanosine RNA Capping Transcription, DNA-templated DNA-templated Transcription, Elongation Regulation Of Metabolic Process RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Response To Stress Positive Regulation Of Viral Transcription Viral Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Viral Entry Into Host Cell Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To DNA Damage Stimulus Regulation Of Viral Release From Host Cell Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Macromolecule Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cell Cycle Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Response To Stimulus Cellular Response To Stress Nucleotide-excision Repair Androgen Receptor Signaling Pathway RNA Metabolic Process Cellular Protein Modification Process Transcription-coupled Nucleotide-excision Repair
Tagcloud ?			affymetrix anthracycline anthracyclines atm bc bimodal bub1 damaging enable fan1 fanci fashion impair msh2 msh6 mtmr15 parp2 pcna pms2 polq recql4 regimens residual rpa3 sensitizing survive taxane top2a ube2v2
Tagcloud (Difference) ?			affymetrix anthracycline anthracyclines atm bc bimodal bub1 damaging enable fan1 fanci fashion impair msh2 msh6 mtmr15 parp2 pcna pms2 polq recql4 regimens residual rpa3 sensitizing survive taxane top2a ube2v2
Tagcloud (Intersection) ?