MIB2 and ACTA1

Number of citations of the paper that reports this interaction (PMID 14507647)
3

Data Source:
BioGRID (pull down)

		MIB2	ACTA1
Gene Name		mindbomb E3 ubiquitin protein ligase 2	actin, alpha 1, skeletal muscle
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Early Endosome	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding
	Biological Process	Notch Signaling Pathway Protein Ubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Cell Growth Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Striated Muscle Contraction
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ACTA1 ACTC1 BCL10 GRIN2B JAG2 TBK1 UBE2N UBE2U	107 interactors: ABL1 ABRA ACTR10 ACTR1B ADSS AFAP1 AIF1 AJUBA AMOT CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1
Entrez ID		142678	58
HPRD ID		15905	00030
Ensembl ID		ENSG00000197530	ENSG00000143632
Uniprot IDs		Q96AX9	P68133 Q5T8M7
PDB IDs			1T44
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Thin Filament Assembly Skeletal Myofibril Assembly Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Response To Mechanical Stimulus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Actin-myosin Filament Sliding Muscle Filament Sliding Regulation Of Innate Immune Response Histone Ubiquitination Actin-mediated Cell Contraction Actin Filament-based Movement Response To Stimulus Positive Regulation Of Cytokine Biosynthetic Process Myofibril Assembly Toll-like Receptor 4 Signaling Pathway Epithelial Cell Apoptotic Process Involved In Palatal Shelf Morphogenesis Gamma-delta T Cell Differentiation Immune Response-regulating Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Cytokine Biosynthetic Process Response To Organic Substance Defense Response T Cell Receptor Signaling Pathway Actomyosin Structure Organization Positive Regulation Of Mast Cell Cytokine Production Skeletal Muscle Fiber Adaptation Lymphotoxin A Biosynthetic Process Interleukin-6 Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Stimulus Positive Regulation Of Protein Ubiquitination Antigen Receptor-mediated Signaling Pathway Cytokine Production Positive Regulation Of Immune Response Response To Ethanol Tissue Morphogenesis Striated Muscle Cell Development Regulation Of Histone Ubiquitination Dendritic Cell Proliferation Negative Regulation Of Mature B Cell Apoptotic Process Protein Polyubiquitination Muscle Cell Development Morphogenesis Of Embryonic Epithelium Tissue Development Regulation Of Intracellular Signal Transduction	Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Actin Filament-based Movement Muscle Contraction Muscle System Process Cell Projection Organization Organelle Organization Negative Regulation Of Protein Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Cellular Component Assembly Developmental Process Anatomical Structure Morphogenesis Anatomical Structure Development Negative Regulation Of Protein Complex Assembly System Development Actin-mediated Cell Contraction Response To Wounding Locomotion Cell Development Response To External Stimulus Cell Differentiation Wound Healing Multicellular Organismal Development Cell Morphogenesis Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Tissue Development Cell Projection Morphogenesis Chemotaxis Positive Regulation Of Organelle Organization Cell Part Morphogenesis Neuron Development Actin Polymerization Or Depolymerization Blood Coagulation Hemostasis Cell Junction Assembly
Tagcloud ?		a440r adaptor antiviral cascades communications dlais e3 governing indispensable interferon irf3 irf7 k63 l439s ligase ligation mavs mediates mindbomb minimizing motif pulldown sensing spreading synergistically tank tbk1 tightly triggers	annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40
Tagcloud (Difference) ?		a440r adaptor antiviral cascades communications dlais e3 governing indispensable interferon irf3 irf7 k63 l439s ligase ligation mavs mediates mindbomb minimizing motif pulldown sensing spreading synergistically tank tbk1 tightly triggers	annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40
Tagcloud (Intersection) ?