MIB2

Description		MIB E3 ubiquitin protein ligase 2
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Notch Signaling Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling NOTCH3 Activation and Transmission of Signal to the Nucleus Antigen processing: Ubiquitination & Proteasome degradation PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs
Diseases
GWAS		Body mass index ( 26426971) Height ( 31562340) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295)
Novel Interacting Genes		2 novel interacting genes: DNAH7 PUSL1
Interacting Genes		13 interacting genes: ACTA1 ACTC1 BCL10 CYLD GRIN2B JAG2 SRPK2 TBK1 UBC UBE2D1 UBE2D2 UBE2N UBE2U
Entrez ID		142678
HPRD ID		15905
Ensembl ID		ENSG00000197530
Uniprot IDs		A0A8C8N694 A0A8C8USR6 E9PD12 Q96AX9
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity ATP Binding Nucleotide Binding Mesenchyme Migration Skeletal Muscle Thin Filament Assembly Protein Modification Process Negative Regulation Of TORC1 Signaling TORC1 Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Post-translational Protein Modification TOR Signaling Negative Regulation Of TOR Signaling Protein Polyubiquitination Regulation Of TORC1 Signaling Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of T Cell Receptor Signaling Pathway Protein Ubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Post-translational Protein Modification Myosin Binding Immune Response-activating Signaling Pathway Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Regulation Of TOR Signaling Regulation Of Protein Polyubiquitination Proteolysis Defense Response To Symbiont Immune Response-regulating Signaling Pathway Defense Response To Other Organism Pattern Recognition Receptor Signaling Pathway Intracellular Signal Transduction Activation Of Immune Response Innate Immune Response-activating Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Intracellular Signaling Cassette Regulation Of Protein Ubiquitination Peptidyl-serine Phosphorylation Response To Nutrient Levels Activation Of Innate Immune Response Negative Regulation Of Type I Interferon Production Negative Regulation Of Interleukin-18-mediated Signaling Pathway Met1-linked Polyubiquitin Deubiquitinase Activity Epithelial Cell Apoptotic Process Involved In Palatal Shelf Morphogenesis Regulation Of T Cell Receptor Signaling Pathway Sarcomere Cytoplasmic Microtubule
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