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MIB2
Gene Name
mindbomb E3 ubiquitin protein ligase 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Ubiquitin Ligase Complex
Cytoplasm
Early Endosome
Molecular Function
Actin Binding
Ubiquitin-protein Transferase Activity
Signal Transducer Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Biological Process
Notch Signaling Pathway
Protein Ubiquitination
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pathways
Signaling by NOTCH1 HD Domain Mutants in Cancer
Constitutive Signaling by NOTCH1 HD Domain Mutants
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
Signaling by NOTCH
NOTCH2 Activation and Transmission of Signal to the Nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Signaling by NOTCH2
Signaling by NOTCH1
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Signaling by NOTCH1 in Cancer
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS
Protein-protein Interactions
8 interactors:
ACTA1
ACTC1
BCL10
GRIN2B
JAG2
TBK1
UBE2N
UBE2U
Entrez ID
142678
HPRD ID
15905
Ensembl ID
ENSG00000197530
Uniprot IDs
Q96AX9
PDB IDs
Enriched GO Terms of Interacting Partners
?
Skeletal Muscle Thin Filament Assembly
Skeletal Myofibril Assembly
Toll-like Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Innate Immune Response
Response To Mechanical Stimulus
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Actin-myosin Filament Sliding
Muscle Filament Sliding
Regulation Of Innate Immune Response
Histone Ubiquitination
Actin-mediated Cell Contraction
Actin Filament-based Movement
Response To Stimulus
Positive Regulation Of Cytokine Biosynthetic Process
Myofibril Assembly
Toll-like Receptor 4 Signaling Pathway
Epithelial Cell Apoptotic Process Involved In Palatal Shelf Morphogenesis
Gamma-delta T Cell Differentiation
Immune Response-regulating Signaling Pathway
Anatomical Structure Morphogenesis
Regulation Of Cytokine Biosynthetic Process
Response To Organic Substance
Defense Response
T Cell Receptor Signaling Pathway
Actomyosin Structure Organization
Positive Regulation Of Mast Cell Cytokine Production
Skeletal Muscle Fiber Adaptation
Lymphotoxin A Biosynthetic Process
Interleukin-6 Biosynthetic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cellular Response To Stimulus
Positive Regulation Of Protein Ubiquitination
Antigen Receptor-mediated Signaling Pathway
Cytokine Production
Positive Regulation Of Immune Response
Response To Ethanol
Tissue Morphogenesis
Striated Muscle Cell Development
Regulation Of Histone Ubiquitination
Dendritic Cell Proliferation
Negative Regulation Of Mature B Cell Apoptotic Process
Protein Polyubiquitination
Muscle Cell Development
Morphogenesis Of Embryonic Epithelium
Tissue Development
Regulation Of Intracellular Signal Transduction
Tagcloud
?
a440r
adaptor
antiviral
cascades
communications
dlais
e3
governing
indispensable
interferon
irf3
irf7
k63
l439s
ligase
ligation
mavs
mediates
mindbomb
minimizing
motif
pulldown
sensing
spreading
synergistically
tank
tbk1
tightly
triggers