MIB2 and UBE2U

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		MIB2	UBE2U
Gene Name		mindbomb E3 ubiquitin protein ligase 2	ubiquitin-conjugating enzyme E2U (putative)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Early Endosome	Nuclear Chromatin Cytoplasm HULC Complex
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity	ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Notch Signaling Pathway Protein Ubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling	Protein Polyubiquitination DNA Repair Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ACTA1 ACTC1 BCL10 GRIN2B JAG2 TBK1 UBE2N UBE2U	66 interactors: ANAPC11 BARD1 BFAR CADPS2 CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 VPS11 VPS41 ZSWIM2
Entrez ID		142678	148581
HPRD ID		15905	14599
Ensembl ID		ENSG00000197530	ENSG00000177414
Uniprot IDs		Q96AX9	Q5VVX9
PDB IDs			1YRV
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Thin Filament Assembly Skeletal Myofibril Assembly Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Response To Mechanical Stimulus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Actin-myosin Filament Sliding Muscle Filament Sliding Regulation Of Innate Immune Response Histone Ubiquitination Actin-mediated Cell Contraction Actin Filament-based Movement Response To Stimulus Positive Regulation Of Cytokine Biosynthetic Process Myofibril Assembly Toll-like Receptor 4 Signaling Pathway Epithelial Cell Apoptotic Process Involved In Palatal Shelf Morphogenesis Gamma-delta T Cell Differentiation Immune Response-regulating Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Cytokine Biosynthetic Process Response To Organic Substance Defense Response T Cell Receptor Signaling Pathway Actomyosin Structure Organization Positive Regulation Of Mast Cell Cytokine Production Skeletal Muscle Fiber Adaptation Lymphotoxin A Biosynthetic Process Interleukin-6 Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Stimulus Positive Regulation Of Protein Ubiquitination Antigen Receptor-mediated Signaling Pathway Cytokine Production Positive Regulation Of Immune Response Response To Ethanol Tissue Morphogenesis Striated Muscle Cell Development Regulation Of Histone Ubiquitination Dendritic Cell Proliferation Negative Regulation Of Mature B Cell Apoptotic Process Protein Polyubiquitination Muscle Cell Development Morphogenesis Of Embryonic Epithelium Tissue Development Regulation Of Intracellular Signal Transduction	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Negative Regulation Of Viral Release From Host Cell Protein Metabolic Process Regulation Of Viral Release From Host Cell Protein Polyubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Viral Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Viral Process Protein Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Innate Immune Response Proteasomal Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Macromolecule Catabolic Process Regulation Of Protein Stability Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone H2A Monoubiquitination Regulation Of Gene Expression Histone H2A Ubiquitination Histone H2A-K119 Monoubiquitination Immune Response Regulation Of Intracellular Transport Cellular Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Defense Response Interferon-gamma-mediated Signaling Pathway Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Negative Regulation Of Cellular Metabolic Process Regulation Of Viral Entry Into Host Cell Response To Stress Negative Regulation Of Viral Transcription Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Cellular Response To Interferon-gamma Protein Destabilization Regulation Of Signal Transduction
Tagcloud ?		a440r adaptor antiviral cascades communications dlais e3 governing indispensable interferon irf3 irf7 k63 l439s ligase ligation mavs mediates mindbomb minimizing motif pulldown sensing spreading synergistically tank tbk1 tightly triggers
Tagcloud (Difference) ?		a440r adaptor antiviral cascades communications dlais e3 governing indispensable interferon irf3 irf7 k63 l439s ligase ligation mavs mediates mindbomb minimizing motif pulldown sensing spreading synergistically tank tbk1 tightly triggers
Tagcloud (Intersection) ?