MIB2 and JAG2

Number of citations of the paper that reports this interaction (PMID 15920166)
12

Data Source:
BioGRID (pull down)

		MIB2	JAG2
Gene Name		mindbomb E3 ubiquitin protein ligase 2	jagged 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Early Endosome	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity	Notch Binding Calcium Ion Binding Protein Binding Growth Factor Activity
	Biological Process	Notch Signaling Pathway Protein Ubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling	Skeletal System Development In Utero Embryonic Development Respiratory System Process Cell Cycle Notch Signaling Pathway Notch Receptor Processing Spermatogenesis Auditory Receptor Cell Fate Commitment Morphogenesis Of Embryonic Epithelium Cell Differentiation Regulation Of Cell Adhesion T Cell Differentiation Regulation Of Cell Migration Regulation Of Cell Proliferation Odontogenesis Of Dentin-containing Tooth Gamma-delta T Cell Differentiation Thymic T Cell Selection Epithelial Cell Apoptotic Process Involved In Palatal Shelf Morphogenesis
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Signaling by NOTCH4 Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ACTA1 ACTC1 BCL10 GRIN2B JAG2 TBK1 UBE2N UBE2U	8 interactors: ATN1 ATXN7 CACNA1A GFI1B MIB2 NOTCH1 NOTCH2 NOTCH3
Entrez ID		142678	3714
HPRD ID		15905	03981
Ensembl ID		ENSG00000197530	ENSG00000184916
Uniprot IDs		Q96AX9	Q9Y219
PDB IDs
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Thin Filament Assembly Skeletal Myofibril Assembly Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Response To Mechanical Stimulus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Actin-myosin Filament Sliding Muscle Filament Sliding Regulation Of Innate Immune Response Histone Ubiquitination Actin-mediated Cell Contraction Actin Filament-based Movement Response To Stimulus Positive Regulation Of Cytokine Biosynthetic Process Myofibril Assembly Toll-like Receptor 4 Signaling Pathway Epithelial Cell Apoptotic Process Involved In Palatal Shelf Morphogenesis Gamma-delta T Cell Differentiation Immune Response-regulating Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Cytokine Biosynthetic Process Response To Organic Substance Defense Response T Cell Receptor Signaling Pathway Actomyosin Structure Organization Positive Regulation Of Mast Cell Cytokine Production Skeletal Muscle Fiber Adaptation Lymphotoxin A Biosynthetic Process Interleukin-6 Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Stimulus Positive Regulation Of Protein Ubiquitination Antigen Receptor-mediated Signaling Pathway Cytokine Production Positive Regulation Of Immune Response Response To Ethanol Tissue Morphogenesis Striated Muscle Cell Development Regulation Of Histone Ubiquitination Dendritic Cell Proliferation Negative Regulation Of Mature B Cell Apoptotic Process Protein Polyubiquitination Muscle Cell Development Morphogenesis Of Embryonic Epithelium Tissue Development Regulation Of Intracellular Signal Transduction	Notch Receptor Processing Notch Signaling Pathway Interleukin-4 Secretion Notch Signaling Involved In Heart Development Pulmonary Valve Morphogenesis Interleukin-4 Production Negative Regulation Of Cellular Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Transcription, DNA-templated Glomerulus Vasculature Development RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-templated Transcription, Initiation Cardiac Atrium Morphogenesis Inflammatory Response To Antigenic Stimulus Cytokine Secretion Heart Valve Morphogenesis Heart Valve Development Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Fate Commitment Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Cardiac Septum Morphogenesis Regulation Of Calcium Ion-dependent Exocytosis Central Nervous System Development Glomerulus Development Morphogenesis Of An Epithelial Sheet Cell Differentiation In Spinal Cord Gene Expression Cell Death Death Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Neuron Fate Commitment Cardiac Septum Development Regulation Of BMP Signaling Pathway Cerebellar Molecular Layer Development Venous Endothelial Cell Differentiation Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Nervous System Development Growth Secretion By Cell Blood Vessel Development Negative Regulation Of Gene Expression
Tagcloud ?		a440r adaptor antiviral cascades communications dlais e3 governing indispensable interferon irf3 irf7 k63 l439s ligase ligation mavs mediates mindbomb minimizing motif pulldown sensing spreading synergistically tank tbk1 tightly triggers	bisulfite cerebellum dll1 enrichment enzymatic epigenetics homeostasis hydroxymethylation hydroxymethylcytosine hypomethylation intercellular intergenic intragenic myoblasts myofibers myotubes nonmuscle notch notch1 notch2 poised precisely renewal representation rrbs skeletal spatially temporally unusually
Tagcloud (Difference) ?		a440r adaptor antiviral cascades communications dlais e3 governing indispensable interferon irf3 irf7 k63 l439s ligase ligation mavs mediates mindbomb minimizing motif pulldown sensing spreading synergistically tank tbk1 tightly triggers	bisulfite cerebellum dll1 enrichment enzymatic epigenetics homeostasis hydroxymethylation hydroxymethylcytosine hypomethylation intercellular intergenic intragenic myoblasts myofibers myotubes nonmuscle notch notch1 notch2 poised precisely renewal representation rrbs skeletal spatially temporally unusually
Tagcloud (Intersection) ?