MIB2 and ACTC1

Number of citations of the paper that reports this interaction (PubMedID 14507647)
35

Data Source:
HPRD (two hybrid, in vitro)

		MIB2	ACTC1
Description		MIB E3 ubiquitin protein ligase 2	actin alpha cardiac muscle 1
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane	Extracellular Space Cytoplasm Cytosol Cytoskeleton Actin Filament Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Lamellipodium Filopodium I Band Cell Body Synapse Extracellular Exosome Blood Microparticle Glutamatergic Synapse
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Microfilament Motor Activity Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity Myosin Binding
	Biological Process	Notch Signaling Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction	Actin Filament Organization Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Actin Filament-based Movement Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Cytoplasmic Actin-based Contraction Involved In Cell Motility Mesenchyme Migration
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling NOTCH3 Activation and Transmission of Signal to the Nucleus Antigen processing: Ubiquitination & Proteasome degradation PD-L1(CD274) glycosylation and translocation to plasma membrane	Striated Muscle Contraction RHOA GTPase cycle RHOB GTPase cycle Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Diseases			Dilated cardiomyopathy (DCM) Hypertrophic cardiomyopathy (HCM) Atrial septal defect
GWAS		Body mass index ( 26426971) Height ( 31562340) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295)	Axial length ( 24144296) Refractive error ( 20835239 32231278)
Interacting Genes		13 interacting genes: ACTA1 ACTC1 BCL10 CYLD GRIN2B JAG2 SRPK2 TBK1 UBC UBE2D1 UBE2D2 UBE2N UBE2U	43 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG ASH2L BCL11A C1QTNF9 CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 LINC00624 MIB2 MPC1 MYLK OGT PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1
Entrez ID		142678	70
HPRD ID		15905	00015
Ensembl ID		ENSG00000197530	ENSG00000159251
Uniprot IDs		A0A8C8N694 A0A8C8USR6 E9PD12 Q96AX9	B3KPP5 P68032
PDB IDs			8GSU 8GSW 8GT1 8GT2 8GT3 8GT4 8GT5 8ZB7 8ZI9 8ZJ1 9B3Q 9B3R
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity ATP Binding Nucleotide Binding Mesenchyme Migration Skeletal Muscle Thin Filament Assembly Protein Modification Process Negative Regulation Of TORC1 Signaling TORC1 Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Post-translational Protein Modification TOR Signaling Negative Regulation Of TOR Signaling Protein Polyubiquitination Regulation Of TORC1 Signaling Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of T Cell Receptor Signaling Pathway Protein Ubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Post-translational Protein Modification Myosin Binding Immune Response-activating Signaling Pathway Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Regulation Of TOR Signaling Regulation Of Protein Polyubiquitination Proteolysis Defense Response To Symbiont Immune Response-regulating Signaling Pathway Defense Response To Other Organism Pattern Recognition Receptor Signaling Pathway Intracellular Signal Transduction Activation Of Immune Response Innate Immune Response-activating Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Intracellular Signaling Cassette Regulation Of Protein Ubiquitination Peptidyl-serine Phosphorylation Response To Nutrient Levels Activation Of Innate Immune Response Negative Regulation Of Type I Interferon Production Negative Regulation Of Interleukin-18-mediated Signaling Pathway Met1-linked Polyubiquitin Deubiquitinase Activity Epithelial Cell Apoptotic Process Involved In Palatal Shelf Morphogenesis Regulation Of T Cell Receptor Signaling Pathway Sarcomere Cytoplasmic Microtubule	Actin Binding Actin Cytoskeleton Actin Filament Binding Cytoskeleton Actin Filament-based Process Actin Filament Organization Cytoplasm Focal Adhesion Regulation Of Lamellipodium Assembly Actin Filament Supramolecular Fiber Organization Regulation Of Lamellipodium Organization Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Myofibril Cell Projection Assembly Lamellipodium Regulation Of Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Organization Regulation Of Cell Projection Organization Cortical Cytoskeleton Z Disc Postsynaptic Actin Cytoskeleton Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cell Projection Assembly Filopodium Regulation Of Actin Cytoskeleton Organization Stress Fiber Plasma Membrane Bounded Cell Projection Assembly Negative Regulation Of Actin Filament Depolymerization Regulation Of Cellular Component Size Regulation Of Actin Filament-based Process Cell Projection Regulation Of Actin Filament Depolymerization Regulation Of Protein-containing Complex Assembly Brush Border Regulation Of Actin Filament Polymerization Actin Filament-based Movement Extracellular Exosome Cytosol Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Actin Filament Organization Cell Projection Organization
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