BRAF and RHEB

Number of citations of the paper that reports this interaction (PubMedID 16803888)
0

Data Source:
HPRD (in vitro)

		BRAF	RHEB
Description		B-Raf proto-oncogene, serine/threonine kinase	Ras homolog, mTORC1 binding
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cilium Membrane Centriolar Satellite Ciliary Basal Body Neuron Projection Cell Body Presynapse Postsynapse Glutamatergic Synapse	Golgi Membrane Spliceosomal Complex Cytoplasm Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Endomembrane System Postsynaptic Density Membrane Synapse Extracellular Exosome
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Small GTPase Binding Identical Protein Binding Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity	Nucleotide Binding Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Kinase Binding Protein Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding
	Biological Process	MAPK Cascade Myeloid Progenitor Cell Differentiation Protein Phosphorylation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Visual Learning Animal Organ Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Fibroblast Migration Positive Regulation Of D-glucose Transmembrane Transport Synaptic Vesicle Exocytosis Cell Differentiation Thyroid Gland Development T Cell Differentiation In Thymus Positive Regulation Of Peptidyl-serine Phosphorylation Substrate Adhesion-dependent Cell Spreading Somatic Stem Cell Population Maintenance Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Stress Fiber Assembly CD4-positive, Alpha-beta T Cell Differentiation Positive T Cell Selection CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Neuron Apoptotic Process Regulation Of T Cell Differentiation Alpha-beta T Cell Differentiation Thymus Development Regulation Of Axon Regeneration Positive Regulation Of Axon Regeneration Positive Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Long-term Synaptic Potentiation Head Morphogenesis Face Development ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Calcium Ion Cellular Response To Xenobiotic Stimulus Endothelial Cell Apoptotic Process Establishment Of Protein Localization To Membrane Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Synaptic Vesicle Exocytosis Negative Regulation Of Endothelial Cell Apoptotic Process	Autophagosome Assembly Cytoplasmic Translation Signal Transduction Small GTPase-mediated Signal Transduction Response To Virus Negative Regulation Of Autophagy Regulation Of Macroautophagy Cellular Response To Nutrient Levels Regulation Of TOR Signaling Positive Regulation Of TOR Signaling TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Cell Cycle Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of TORC1 Signaling Regulation Of Type B Pancreatic Cell Development
Pathways		Spry regulation of FGF signaling Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation Signalling to p38 via RIT and RIN RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling	Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs		Sorafenib XL281 RAF-265 PLX-4720 N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamide (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime Vemurafenib Regorafenib Dabrafenib Encorafenib Fostamatinib Ripretinib	Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases		Malignant melanoma Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS) Thyroid cancer
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Cerebrospinal fluid t-tau:AB1-42 ratio ( 26252872) Cerebrospinal T-tau levels ( 26252872) Longevity ( 33657282) Mild influenza (H1N1) infection ( 26379185) Response to Vitamin E supplementation ( 22437554) Type 2 diabetes ( 28869590 32499647)	Carboplatin disposition in epthelial ovarian cancer ( 29367611) Metabolite levels ( 23823483)
Interacting Genes		44 interacting genes: AKT1 AURKA BAD CCDC88A CTSV FBP1 HRAS HSD17B3 ITCH LATS2 MAP2K1 MAP2K2 MAP2K3 MAP2K6 MAPK1 MAPK3 MRAS NANOG OIP5 PAK2 PEBP1 PPP2CA PPP2R2A PRKACA PRKCE RAF1 RAP1A RAP1GAP RASSF1 RHEB SFN SGK1 SPOP SPRY2 STK11 TERF1 TERT YWHAB YWHAG YWHAH YWHAQ YWHAZ ZNF189 ZNF510	29 interacting genes: A2M APOE APPBP2 ARIH2 ATM ATR BNIP3 BNIP3L BRAF CREB3 ECSIT FKBP8 HTT MTOR NCAM1 PDE6D PLD1 PSEN1 PSEN2 RABAC1 RAF1 RNF152 RPS6KB1 RPTOR TRIM55 TRIM63 TSC1 TSC2 USP4
Entrez ID		673	6009
HPRD ID		01264	03188
Ensembl ID		ENSG00000157764	ENSG00000106615
Uniprot IDs		A0A2R8Y8E0 A0A2U3TZI2 H7C560 P15056	A0A090N900 Q15382
PDB IDs		1UWH 1UWJ 2FB8 2L05 3C4C 3D4Q 3IDP 3II5 3NY5 3OG7 3PPJ 3PPK 3PRF 3PRI 3PSB 3PSD 3Q4C 3Q96 3SKC 3TV4 3TV6 4CQE 4DBN 4E26 4E4X 4EHE 4EHG 4FC0 4FK3 4G9C 4G9R 4H58 4JVG 4KSP 4KSQ 4MBJ 4MNE 4MNF 4PP7 4R5Y 4RZV 4RZW 4WO5 4XV1 4XV2 4XV3 4XV9 4YHT 5C9C 5CSW 5CSX 5CT7 5FD2 5HI2 5HID 5HIE 5ITA 5J17 5J18 5J2R 5JRQ 5JSM 5JT2 5VAL 5VAM 5VR3 5VYK 6B8U 6CAD 6N0P 6N0Q 6NSQ 6NYB 6P3D 6P7G 6PP9 6Q0J 6Q0K 6Q0T 6U2G 6U2H 6UAN 6UUO 6V2U 6V2W 6V34 6XAG 6XFP 6XLO 7K0V 7M0T 7M0U 7M0V 7M0W 7M0X 7M0Y 7M0Z 7MFD 7MFE 7MFF 7P3V 7SHV 7ZR0 7ZR5 7ZR6 8C7X 8C7Y 8DGS 8DGT 8F7O 8F7P 8QQG 9AXX 9AXY 9BFB 9F35	1XTQ 1XTR 1XTS 3SEA 3T5G 5YXH 6BCU 6BSX 6BT0 7BTA 7BTC 7BTD
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Protein Serine Kinase Activity Intracellular Signaling Cassette Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Regulation Of Protein Modification Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Primary Metabolic Process Protein Kinase Activity Regulation Of Cellular Component Organization Regulation Of Phosphorylation Protein Phosphorylation Regulation Of Macromolecule Metabolic Process Regulation Of MAPK Cascade Schwann Cell Development Regulation Of Metabolic Process Phosphorylation ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway MAPK Cascade Kinase Activity Regulation Of Golgi Inheritance Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Catalytic Activity Protein Kinase Binding Positive Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Regulation Of Cellular Localization Regulation Of Protein Localization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Positive Regulation Of Cellular Component Organization Cytosol Trachea Formation Positive Regulation Of Intracellular Signal Transduction TOR Signaling Positive Regulation Of Protein Modification Process	Intracellular Signal Transduction Regulation Of Autophagy Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling TORC1 Signaling TOR Signaling Negative Regulation Of TOR Signaling Regulation Of TOR Signaling Positive Regulation Of Translational Initiation Positive Regulation Of TOR Signaling Response To Nutrient Levels Positive Regulation Of Autophagy Regulation Of Macroautophagy Response To Stress Positive Regulation Of Catabolic Process Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Translation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Translational Initiation Cellular Response To Nutrient Levels Regulation Of Autophagy Of Mitochondrion Regulation Of Translational Initiation Protein Metabolic Process Apoptotic Process Positive Regulation Of Cell Communication Programmed Cell Death Cell Death Cytoplasmic Translation Response To Starvation Signal Transduction Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Golgi Apparatus Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Autophagosome Assembly Positive Regulation Of Metabolic Process Positive Regulation Of Macroautophagy Cellular Response To Starvation Negative Regulation Of Signal Transduction Autophagosome Organization Regulation Of Apoptotic Process Negative Regulation Of Autophagy Regulation Of Mitophagy Protein Catabolic Process Thymus Development Regulation Of Intracellular Signal Transduction
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?