BRAF and HSD17B3

Number of citations: 0 (PubMedID 24412244)
Data Source: BioGRID (two hybrid)

		BRAF	HSD17B3
Name		B-Raf proto-oncogene, serine/threonine kinase	hydroxysteroid 17-beta dehydrogenase 3
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cilium Membrane Centriolar Satellite Ciliary Basal Body Neuron Projection Cell Body Presynapse Postsynapse Glutamatergic Synapse	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Small GTPase Binding Identical Protein Binding Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity	Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Oxidoreductase Activity Testosterone Dehydrogenase (NADP+) Activity 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity
	Biological Process	MAPK Cascade Myeloid Progenitor Cell Differentiation Protein Phosphorylation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Visual Learning Animal Organ Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Fibroblast Migration Positive Regulation Of D-glucose Transmembrane Transport Synaptic Vesicle Exocytosis Cell Differentiation Thyroid Gland Development T Cell Differentiation In Thymus Positive Regulation Of Peptidyl-serine Phosphorylation Substrate Adhesion-dependent Cell Spreading Somatic Stem Cell Population Maintenance Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Stress Fiber Assembly CD4-positive, Alpha-beta T Cell Differentiation Positive T Cell Selection CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Neuron Apoptotic Process Regulation Of T Cell Differentiation Alpha-beta T Cell Differentiation Thymus Development Regulation Of Axon Regeneration Positive Regulation Of Axon Regeneration Positive Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Long-term Synaptic Potentiation Head Morphogenesis Face Development ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Calcium Ion Cellular Response To Xenobiotic Stimulus Endothelial Cell Apoptotic Process Establishment Of Protein Localization To Membrane Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Synaptic Vesicle Exocytosis Negative Regulation Of Endothelial Cell Apoptotic Process	Lipid Metabolic Process Steroid Biosynthetic Process Androgen Biosynthetic Process Male Genitalia Development Testosterone Biosynthetic Process
Pathways		Spry regulation of FGF signaling Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation Signalling to p38 via RIT and RIN RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling	Androgen biosynthesis Synthesis of very long-chain fatty acyl-CoAs
Drugs		Sorafenib XL281 RAF-265 PLX-4720 N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamide (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime Vemurafenib Regorafenib Dabrafenib Encorafenib Fostamatinib Ripretinib	NADH
Diseases		Malignant melanoma Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS) Thyroid cancer	46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Bipolar disorder ( 31043756 ) Cerebrospinal fluid t-tau:AB1-42 ratio ( 26252872 ) Cerebrospinal T-tau levels ( 26252872 ) Longevity ( 33657282 ) Mild influenza (H1N1) infection ( 26379185 ) Response to Vitamin E supplementation ( 22437554 ) Type 2 diabetes ( 28869590 32499647 )	Cerebrospinal fluid AB1-42 levels ( 26252872 ) Glomerular filtration rate in chronic kidney disease ( 26420894 ) Letter-number span reordering ( 31596458 )
Interacting Genes		44 interacting genes: AKT1 AURKA BAD CCDC88A CTSV FBP1 HRAS HSD17B3 ITCH LATS2 MAP2K1 MAP2K2 MAP2K3 MAP2K6 MAPK1 MAPK3 MRAS NANOG OIP5 PAK2 PEBP1 PPP2CA PPP2R2A PRKACA PRKCE RAF1 RAP1A RAP1GAP RASSF1 RHEB SFN SGK1 SPOP SPRY2 STK11 TERF1 TERT YWHAB YWHAG YWHAH YWHAQ YWHAZ ZNF189 ZNF510	9 interacting genes: BRAF BUB1 CDH1 CTNNA1 DLC1 ERBB2 MCC MLH3 SMAD2
Entrez ID		673	3293
HPRD ID		01264	05716
Ensembl ID		ENSG00000157764	ENSG00000130948
Uniprot IDs		A0A2R8Y8E0 A0A2U3TZI2 H7C560 P15056	P37058 Q6FH62
PDB IDs		1UWH 1UWJ 2FB8 2L05 3C4C 3D4Q 3IDP 3II5 3NY5 3OG7 3PPJ 3PPK 3PRF 3PRI 3PSB 3PSD 3Q4C 3Q96 3SKC 3TV4 3TV6 4CQE 4DBN 4E26 4E4X 4EHE 4EHG 4FC0 4FK3 4G9C 4G9R 4H58 4JVG 4KSP 4KSQ 4MBJ 4MNE 4MNF 4PP7 4R5Y 4RZV 4RZW 4WO5 4XV1 4XV2 4XV3 4XV9 4YHT 5C9C 5CSW 5CSX 5CT7 5FD2 5HI2 5HID 5HIE 5ITA 5J17 5J18 5J2R 5JRQ 5JSM 5JT2 5VAL 5VAM 5VR3 5VYK 6B8U 6CAD 6N0P 6N0Q 6NSQ 6NYB 6P3D 6P7G 6PP9 6Q0J 6Q0K 6Q0T 6U2G 6U2H 6UAN 6UUO 6V2U 6V2W 6V34 6XAG 6XFP 6XLO 7K0V 7M0T 7M0U 7M0V 7M0W 7M0X 7M0Y 7M0Z 7MFD 7MFE 7MFF 7P3V 7SHV 7ZR0 7ZR5 7ZR6 8C7X 8C7Y 8DGS 8DGT 8F7O 8F7P 8QQG 9AXX 9AXY 9BFB 9F35	Not available
GO Terms Enriched among Interactors		Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Protein Serine Kinase Activity Intracellular Signaling Cassette Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Regulation Of Protein Modification Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Primary Metabolic Process Protein Kinase Activity Regulation Of Cellular Component Organization Regulation Of Phosphorylation Protein Phosphorylation Regulation Of Macromolecule Metabolic Process Regulation Of MAPK Cascade Schwann Cell Development Regulation Of Metabolic Process Phosphorylation ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway MAPK Cascade Kinase Activity Regulation Of Golgi Inheritance Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Catalytic Activity Protein Kinase Binding Positive Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Regulation Of Cellular Localization Regulation Of Protein Localization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Positive Regulation Of Cellular Component Organization Cytosol Trachea Formation Positive Regulation Of Intracellular Signal Transduction TOR Signaling Positive Regulation Of Protein Modification Process	Negative Regulation Of Locomotion Negative Regulation Of Cell Motility Cellular Response To Indole-3-methanol Response To Indole-3-methanol Flotillin Complex Negative Regulation Of Cell Migration Gamma-catenin Binding Cell Junction Organization Regulation Of Locomotion Animal Organ Morphogenesis Regulation Of Cell Motility Catenin Complex Lamellipodium Postsynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Multicellular Organismal Process Animal Organ Development Regulation Of Cell Communication Regulation Of Signaling Cell Junction Assembly Negative Regulation Of Cell Differentiation Negative Regulation Of Cell Development Cortical Actin Cytoskeleton Response To Alcohol Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Regulation Of Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Negative Regulation Of Cell Adhesion Regulation Of Cell Development Regulation Of Cell Differentiation ERBB Signaling Pathway Regulation Of Neurogenesis Regulation Of Cell Population Proliferation Intracellular Signal Transduction Regulation Of Cell Migration Regulation Of Stress Fiber Assembly Identical Protein Binding Negative Regulation Of Developmental Process Intracellular Protein Localization Anchoring Junction ERBB3:ERBB2 Complex Regulation Of Rho Protein Signal Transduction Homomeric SMAD Protein Complex Hindbrain Morphogenesis Chiasma Ruffle Membrane Regulation Of Nervous System Development Beta-catenin Binding