PRKD1 and AKAP13

Number of citations of the paper that reports this interaction (PMID 15383279)
51

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		PRKD1	AKAP13
Gene Name		protein kinase D1	A kinase (PRKA) anchor protein 13
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Cortex	Nucleus Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Identical Protein Binding Metal Ion Binding	CAMP-dependent Protein Kinase Activity Signal Transducer Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Rho GTPase Binding Protein Complex Scaffold Metal Ion Binding Protein Kinase A Binding
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Sphingolipid Metabolic Process Apoptotic Process Inflammatory Response Golgi Organization Signal Transduction Integrin-mediated Signaling Pathway Cell Proliferation Positive Regulation Of Endothelial Cell Migration Regulation Of Keratinocyte Proliferation Positive Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Sphingolipid Biosynthetic Process Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Oxidative Stress Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Endocytosis Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Golgi Vesicle Transport Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Death Protein Kinase D Signaling Positive Regulation Of Histone Deacetylase Activity Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Integrin-mediated Signaling Pathway	Protein Phosphorylation Small GTPase Mediated Signal Transduction Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Nuclear Export Apoptotic Signaling Pathway Regulation Of Glucocorticoid Mediated Signaling Pathway
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis	Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Body mass index ( 23669352 20935630) Obesity-related traits ( 23251661)	Central corneal thickness ( 20719862) Corneal structure ( 23291589)
Protein-Protein Interactions		31 interactors: ABL1 ADAP1 AKAP13 BTK C1QBP COPS2 COPS5 COPS7A EGFR EPAS1 GNB2L1 HDAC5 HDAC7 HSPB1 IBTK IGF1R JUN KIDINS220 MAPK8 MAPK9 MT2A PLCG1 PLCG2 PPP1R14A PRKCE PRKCH SRC SYK TP53 YWHAQ YWHAZ	20 interactors: CTNNAL1 DYT10 ESR1 ESR2 GNA12 GNAQ MAP1LC3A PPARA PRKACA PRKAR2A PRKD1 RANBP2 RHOA RTKN RXRB THRA YWHAB YWHAE YWHAG YWHAZ
Entrez ID		5587	11214
HPRD ID		05668	05253
Ensembl ID		ENSG00000184304	ENSG00000170776
Uniprot IDs		F8WBA3 Q15139	B0AZU4 Q12802
PDB IDs			2DRN 2LG1
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Cell Activation Regulation Of Phosphorylation Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Death Immune Response Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Defense Response Enzyme Linked Receptor Protein Signaling Pathway Signaling Regulation Of Signaling Blood Coagulation Hemostasis Cell Communication Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Innate Immune Response Response To Organic Substance Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Wounding Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Transport Apoptotic Process Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Response To Stimulus Response To Growth Factor Programmed Cell Death Wound Healing Regulation Of Protein Metabolic Process Positive Regulation Of Cell Death Cellular Response To Organic Substance Cell Death Death Regulation Of Cell Motility Positive Regulation Of Metabolic Process Positive Regulation Of Immune Response Response To Stress	Cell Communication Signal Transduction Cellular Response To Stimulus Cellular Response To Organic Substance Signaling Cellular Response To Hormone Stimulus Regulation Of Intracellular Transport Regulation Of Establishment Of Protein Localization Response To Stimulus Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Protein Localization Response To Organic Substance Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Steroid Hormone Mediated Signaling Pathway Response To Hormone Positive Regulation Of Intracellular Transport Intracellular Signal Transduction Regulation Of Cellular Localization Hormone-mediated Signaling Pathway Positive Regulation Of Phospholipase C Activity Rho Protein Signal Transduction Positive Regulation Of Mitochondrion Organization Transcription Initiation From RNA Polymerase II Promoter Apoptotic Signaling Pathway Cellular Response To Steroid Hormone Stimulus Wound Healing Intrinsic Apoptotic Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Platelet Activation Apoptotic Process Cellular Response To Organic Cyclic Compound Regulation Of Signaling Programmed Cell Death Positive Regulation Of Organelle Organization Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Phospholipase Activity Response To Wounding Positive Regulation Of Lipase Activity Ras Protein Signal Transduction Blood Coagulation Cell Death Death Neurotrophin Signaling Pathway Hemostasis DNA-templated Transcription, Initiation Regulation Of Mitochondrion Organization Negative Regulation Of Kinase Activity
Tagcloud ?		adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 evl fbxw7 galns gnas iranian lgr mmp2 msi msp mss p2rx7 parsimony ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22	anchoring assume bifunctional bundle causation chair crisis dbl deregulated dh dynamical explains gdp gef gtpase guanine helical hyperactive lbc linker mediation onco pleckstrin possessing rhoa rigid scattering seat solitary
Tagcloud (Difference) ?		adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 evl fbxw7 galns gnas iranian lgr mmp2 msi msp mss p2rx7 parsimony ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22	anchoring assume bifunctional bundle causation chair crisis dbl deregulated dh dynamical explains gdp gef gtpase guanine helical hyperactive lbc linker mediation onco pleckstrin possessing rhoa rigid scattering seat solitary
Tagcloud (Intersection) ?