PRKD1 and SPRY2

Number of citations of the paper that reports this interaction (PubMedID 19458088)
57

Data Source:
BioGRID (far western blotting, affinity chromatography technology)

		PRKD1	SPRY2
Description		protein kinase D1	sprouty RTK signaling antagonist 2
Image		No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Nucleus Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Cell-cell Junction Cell Cortex Membrane Z Disc Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Membrane Ruffle Membrane Cell Projection Microtubule End
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Heat Shock Protein Binding Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity Phosphatidylinositol 3-kinase Activator Activity	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Serine/threonine Kinase Activator Activity Ubiquitin-protein Transferase Inhibitor Activity Molecular Function Inhibitor Activity
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Immune System Process Apoptotic Process Inflammatory Response Golgi Organization Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Nervous System Development Positive Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Regulation Of Keratinocyte Proliferation Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Contraction By Modulation Of Calcium Ion Sensitivity Of Myofibril Sphingolipid Biosynthetic Process Cell Differentiation Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell-cell Adhesion Mediated By Cadherin Innate Immune Response Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Size Negative Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Positive Regulation Of Protein Export From Nucleus Vascular Endothelial Growth Factor Receptor Signaling Pathway Golgi Vesicle Transport Defense Response To Gram-negative Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Sarcomere Organization Transepithelial Transport Cellular Response To Hydroperoxide Response To Norepinephrine Cellular Response To Norepinephrine Stimulus Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of NLRP3 Inflammasome Complex Assembly Cellular Response To Angiotensin Cellular Response To Phorbol 13-acetate 12-myristate Cellular Response To Endothelin Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Integrin-mediated Signaling Pathway	Establishment Of Mitotic Spindle Orientation Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Angiogenesis Lung Development Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Projection Organization Negative Regulation Of Protein Ubiquitination Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Cell Fate Commitment Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lung Morphogenesis Lung Growth Bud Elongation Involved In Lung Branching Respiratory System Development ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Cellular Response To Leukemia Inhibitory Factor
Pathways		Sphingolipid de novo biosynthesis	Spry regulation of FGF signaling EGFR downregulation
Drugs		Bryostatin 1 Fostamatinib
Diseases
GWAS		Academic attainment (English) ( 33594131) Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 20935630 23669352 25673413 28552196 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) California verbal learning test score ( 31596458) Carotid plaque burden ( 28282560) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Childhood body mass index ( 26604143) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Daytime nap ( 33568662) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hip circumference ( 28552196) Household income (MTAG) ( 31844048) IgM levels ( 28628107) Intelligence (MTAG) ( 29326435) Neurociticism ( 29500382) Obesity-related traits ( 23251661) Schizophrenia ( 30285260 29483656 25056061 34099189) Spatial processing ( 31596458) Systolic blood pressure ( 30224653) Type 2 diabetes ( 30130595) Urinary sodium excretion ( 31409800) Waist circumference ( 28552196 25673412) Weight ( 28552196)	Adiposity ( 21706003) Adventurousness ( 30643258) Body fat percentage ( 26833246) Central corneal thickness ( 32528159) Diastolic blood pressure ( 30224653) Fasting blood insulin (BMI interaction) ( 22581228) General risk tolerance (MTAG) ( 30643258) Height ( 25282103 31562340) Insulin-related traits (multivariate analysis) ( 32002517) Lactose tolerance test ( 31791255) Leisure-time exercise behaviour (age-stratified) ( 30102679) Medication use (drugs used in diabetes) ( 31015401) Methadone dose in opioid dependence ( 28115739) Nonsyndromic cleft lip with cleft palate ( 28232668) Orofacial clefts ( 20023658 22863734) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Sleep duration ( 25469926) Thrombocytopenia in coronary artery bypass surgery ( 30103242) Type 2 diabetes ( 29358691 30718926 32499647 31118516 30297969 30054458 28869590 26818947 24509480 22885922 20862305) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		33 interacting genes: ABL1 ADAP1 AKAP13 BTK C1QBP COPS2 COPS5 COPS7A EGFR EPAS1 HDAC5 HDAC7 IBTK IGF1R JUN KIDINS220 MAPK8 MAPK9 MT2A NOS1 PLCG1 PLCG2 PPP1R14A PRKCE PRKCH RACK1 SPRY2 SRC SYK TFAP2A TP53 USP28 YWHAQ	110 interacting genes: ADAMTSL4 AQP1 ATRIP BAG3 BRAF CATSPER1 CBL CBLB CBLC CHRD CHRNG CREB5 CRIP2 CRMP1 CSTB CTSB DGCR6 DNM2 DSCR9 DYRK1A EIF4E2 FAIM FAM219A FBN1 FBXO7 FRS3 FXR1 FXR2 GNE GP9 GPRIN2 GRAP2 GRB2 GRN HEXIM2 HNRNPLL HOXA1 HSD3B7 ITSN1 KDM1A KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LASP1 LCE1A LCE1B LCE1C LCE1F LCE2D LCE3C LCE3E LCE4A LONRF1 MAPKBP1 MB21D2 MDFI MEOX2 MID2 MKNK1 MLLT6 NCK2 NEDD4 NR1H2 NUBP1 NUFIP2 OTX1 PACSIN3 PLSCR1 PRKAB2 PRKCD PRKD1 PTGER3 PTPN11 RAF1 RTF2 RUNX1T1 SDHB SEMA5B SH3KBP1 SHFL SIAH2 SPRY1 STK16 TCAF1 TMEM14B TNS2 TRAF2 TRIM51 TXNDC5 UBASH3A UBASH3B UBR1 USP20 VPS25 VPS36 ZBTB16 ZNF266 ZNF417 ZNF587
Entrez ID		5587	10253
HPRD ID		05668	03916
Ensembl ID		ENSG00000184304	ENSG00000136158
Uniprot IDs		F8WBA3 Q15139	O43597
PDB IDs			3BUM 3OB1 5HKY 5HKZ 5HL0
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Fc Receptor Signaling Pathway Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Assembly Cytosol Positive Regulation Of Cell Migration Regulation Of Apoptotic Process Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Protein Metabolic Process Regulation Of Protein Modification Process Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Enzyme Binding Signal Transduction Regulation Of Protein-containing Complex Assembly Negative Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein-containing Complex Negative Regulation Of Macromolecule Metabolic Process Protein Phosphorylation Regulation Of Post-translational Protein Modification Positive Regulation Of Intracellular Signal Transduction Kinase Activity Protein Kinase C Binding Response To Lipid Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Positive Regulation Of Epithelial Cell Migration Protein Kinase Activity Cell Activation Regulation Of Protein Neddylation Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Motility Cellular Response To Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Immune Response-regulating Signaling Pathway Regulation Of Locomotion Positive Regulation Of Programmed Cell Death	Intermediate Filament Keratin Filament Keratinization Phosphotyrosine Residue Binding Identical Protein Binding Epidermis Development Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Binding Cytosol Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Receptor Tyrosine Kinase Binding SH3 Domain Binding Regulation Of Signal Transduction Regulation Of Translation At Presynapse, Modulating Synaptic Transmission ESCRT II Complex ERBB Signaling Pathway Tissue Development Ubiquitin-protein Transferase Activity Regulation Of Cell Activation Regulation Of Biological Quality Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Zinc Ion Binding Ubiquitin Protein Ligase Activity
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