PRKD1 and PRKCH

Number of citations of the paper that reports this interaction (PMID 11741879)
34

Data Source:
HPRD (in vitro, in vivo)

		PRKD1	PRKCH
Gene Name		protein kinase D1	protein kinase C, eta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Cortex	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Identical Protein Binding Metal Ion Binding	Protein Kinase C Activity Calcium-independent Protein Kinase C Activity ATP Binding Ral GTPase Binding Enzyme Binding Metal Ion Binding
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Sphingolipid Metabolic Process Apoptotic Process Inflammatory Response Golgi Organization Signal Transduction Integrin-mediated Signaling Pathway Cell Proliferation Positive Regulation Of Endothelial Cell Migration Regulation Of Keratinocyte Proliferation Positive Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Sphingolipid Biosynthetic Process Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Oxidative Stress Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Endocytosis Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Golgi Vesicle Transport Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Death Protein Kinase D Signaling Positive Regulation Of Histone Deacetylase Activity Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Integrin-mediated Signaling Pathway	Protein Phosphorylation Signal Transduction Blood Coagulation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Platelet Activation Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Glial Cell Proliferation Protein Kinase C Signaling Regulation Of Tight Junction Assembly
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis	G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK G alpha (z) signalling events Platelet activation, signaling and aggregation Effects of PIP2 hydrolysis
Drugs
Diseases
GWAS		Body mass index ( 23669352 20935630) Obesity-related traits ( 23251661)	Obesity (early onset extreme) ( 23563609) Reading and spelling ( 23738518) Rheumatoid arthritis ( 22446963) Word reading ( 23738518)
Protein-Protein Interactions		31 interactors: ABL1 ADAP1 AKAP13 BTK C1QBP COPS2 COPS5 COPS7A EGFR EPAS1 GNB2L1 HDAC5 HDAC7 HSPB1 IBTK IGF1R JUN KIDINS220 MAPK8 MAPK9 MT2A PLCG1 PLCG2 PPP1R14A PRKCE PRKCH SRC SYK TP53 YWHAQ YWHAZ	13 interactors: BANP CDK2 FYN GSK3A ITGB2 NFE2L2 NUMB PARD6A PPP1R14A PRKD1 PTPN11 SRC ZBTB8OS
Entrez ID		5587	5583
HPRD ID		05668	05669
Ensembl ID		ENSG00000184304	ENSG00000027075
Uniprot IDs		F8WBA3 Q15139	P24723
PDB IDs			2FK9 3TXO
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Cell Activation Regulation Of Phosphorylation Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Death Immune Response Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Defense Response Enzyme Linked Receptor Protein Signaling Pathway Signaling Regulation Of Signaling Blood Coagulation Hemostasis Cell Communication Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Innate Immune Response Response To Organic Substance Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Wounding Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Transport Apoptotic Process Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Response To Stimulus Response To Growth Factor Programmed Cell Death Wound Healing Regulation Of Protein Metabolic Process Positive Regulation Of Cell Death Cellular Response To Organic Substance Cell Death Death Regulation Of Cell Motility Positive Regulation Of Metabolic Process Positive Regulation Of Immune Response Response To Stress	Cellular Response To Growth Factor Stimulus Response To Growth Factor Integrin-mediated Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Coagulation Innate Immune Response Hemostasis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune Response-regulating Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Leukocyte Migration Neurotrophin Signaling Pathway T Cell Costimulation Regulation Of Body Fluid Levels Chemotaxis Fc Receptor Signaling Pathway Wound Healing Regulation Of Cellular Response To Insulin Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Response To Platelet-derived Growth Factor Negative Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Signaling Pathway Cellular Response To Peptide Cellular Response To Organic Substance Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Wounding Activated T Cell Proliferation Cell Proliferation Locomotion Immune Response Regulation Of Phosphorylation Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Signal Transduction Axon Guidance Cell Migration Phosphatidylinositol-mediated Signaling Response To Oxidative Stress Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Movement Of Cell Or Subcellular Component Regulation Of Phosphorus Metabolic Process Cell Motility
Tagcloud ?		adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 evl fbxw7 galns gnas iranian lgr mmp2 msi msp mss p2rx7 parsimony ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22	adjust adora2a avp cart cecal clp gng7 intramuscular ku myh7 oxt pde1b pdyn preconditioning prkcd puncture ratref reproduced rgs9 rxrg s100a8 sepsis six3 slc17a6 slco1a5 sostdc1 tac1 ttr ulinastatin
Tagcloud (Difference) ?		adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 evl fbxw7 galns gnas iranian lgr mmp2 msi msp mss p2rx7 parsimony ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22	adjust adora2a avp cart cecal clp gng7 intramuscular ku myh7 oxt pde1b pdyn preconditioning prkcd puncture ratref reproduced rgs9 rxrg s100a8 sepsis six3 slc17a6 slco1a5 sostdc1 tac1 ttr ulinastatin
Tagcloud (Intersection) ?