PRKD1 and KIDINS220

Number of citations of the paper that reports this interaction (PMID 10998417)
33

Data Source:
HPRD (in vitro, in vivo)

		PRKD1	KIDINS220
Gene Name		protein kinase D1	kinase D-interacting substrate, 220kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Cortex	Nucleoplasm Late Endosome Cytosol Membrane Integral Component Of Membrane Protein Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Identical Protein Binding Metal Ion Binding	PDZ Domain Binding
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Sphingolipid Metabolic Process Apoptotic Process Inflammatory Response Golgi Organization Signal Transduction Integrin-mediated Signaling Pathway Cell Proliferation Positive Regulation Of Endothelial Cell Migration Regulation Of Keratinocyte Proliferation Positive Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Sphingolipid Biosynthetic Process Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Oxidative Stress Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Endocytosis Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Golgi Vesicle Transport Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Death Protein Kinase D Signaling Positive Regulation Of Histone Deacetylase Activity Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Integrin-mediated Signaling Pathway	Activation Of MAPKK Activity In Utero Embryonic Development Positive Regulation Of Neuron Projection Development Cytoplasmic Transport Nerve Growth Factor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Dendrite Morphogenesis Cellular Response To Nerve Growth Factor Stimulus
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis	ARMS-mediated activation Signalling to ERKs Signalling by NGF Prolonged ERK activation events NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS		Body mass index ( 23669352 20935630) Obesity-related traits ( 23251661)	Neutrophil count ( 21507922)
Protein-Protein Interactions		31 interactors: ABL1 ADAP1 AKAP13 BTK C1QBP COPS2 COPS5 COPS7A EGFR EPAS1 GNB2L1 HDAC5 HDAC7 HSPB1 IBTK IGF1R JUN KIDINS220 MAPK8 MAPK9 MT2A PLCG1 PLCG2 PPP1R14A PRKCE PRKCH SRC SYK TP53 YWHAQ YWHAZ	9 interactors: CDC73 CRKL MOB4 MYC NGFR NTRK1 NTRK2 NTRK3 PRKD1
Entrez ID		5587	57498
HPRD ID		05668	17235
Ensembl ID		ENSG00000184304	ENSG00000134313
Uniprot IDs		F8WBA3 Q15139	Q7Z322 Q9ULH0
PDB IDs
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Cell Activation Regulation Of Phosphorylation Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Death Immune Response Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Defense Response Enzyme Linked Receptor Protein Signaling Pathway Signaling Regulation Of Signaling Blood Coagulation Hemostasis Cell Communication Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Innate Immune Response Response To Organic Substance Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Wounding Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Transport Apoptotic Process Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Response To Stimulus Response To Growth Factor Programmed Cell Death Wound Healing Regulation Of Protein Metabolic Process Positive Regulation Of Cell Death Cellular Response To Organic Substance Cell Death Death Regulation Of Cell Motility Positive Regulation Of Metabolic Process Positive Regulation Of Immune Response Response To Stress	Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Neuron Projection Development Cellular Response To Organic Substance Positive Regulation Of Cell Projection Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Neuron Differentiation Regulation Of Cell Proliferation Regulation Of Neuron Projection Development Response To Organic Substance Positive Regulation Of Neurogenesis Regulation Of Cell Differentiation Regulation Of Signal Transduction Circadian Rhythm Negative Regulation Of Cell Death Regulation Of Cell Projection Organization Positive Regulation Of Cell Development Regulation Of Signaling Regulation Of Neuron Differentiation Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Mechanoreceptor Differentiation Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Axonogenesis Regulation Of Neurogenesis Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Phosphorylation Rhythmic Process Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Positive Regulation Of Cell Proliferation Regulation Of Fibroblast Proliferation Regulation Of Cell Development Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Modification Process
Tagcloud ?		adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 evl fbxw7 galns gnas iranian lgr mmp2 msi msp mss p2rx7 parsimony ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22	acts ankyrin arms cdk cdk4 cdks cyclins ephrin g1 hyperphosphorylation interacting nervous neuroblastoma neurotrophin never organizing platform prb primarily prominent regulate repeat rich scaffold slowdown spanning tightly upregulation
Tagcloud (Difference) ?		adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 evl fbxw7 galns gnas iranian lgr mmp2 msi msp mss p2rx7 parsimony ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22	acts ankyrin arms cdk cdk4 cdks cyclins ephrin g1 hyperphosphorylation interacting nervous neuroblastoma neurotrophin never organizing platform prb primarily prominent regulate repeat rich scaffold slowdown spanning tightly upregulation
Tagcloud (Intersection) ?