S100B and AGER

Number of citations of the paper that reports this interaction (PubMedID 21693575)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		S100B	AGER
Description		S100 calcium binding protein B	advanced glycosylation end-product specific receptor
Image
GO Annotations	Cellular Component	Ruffle Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Microtubule Cytoskeleton Ciliary Basal Body Neuronal Cell Body Perinuclear Region Of Cytoplasm	Fibrillar Center Phagocytic Cup Extracellular Region Nucleus Endosome Early Endosome Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Cell Junction Cell Projection Postsynapse
	Molecular Function	Signaling Receptor Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Metal Ion Binding Tau Protein Binding Calcium-dependent Protein Binding RAGE Receptor Binding	Amyloid-beta Binding DNA Binding RNA Binding Transmembrane Signaling Receptor Activity Scavenger Receptor Activity Laminin Receptor Activity Protein Binding Signaling Receptor Activity Histone Binding Identical Protein Binding S100 Protein Binding Protein-containing Complex Binding Advanced Glycation End-product Receptor Activity Molecular Adaptor Activity
	Biological Process	Cell Adhesion Axonogenesis Central Nervous System Development Learning Or Memory Memory Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Myelination Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Ethanol Positive Regulation Of Neuron Differentiation Regulation Of Neuronal Synaptic Plasticity Astrocyte Differentiation Positive Regulation Of Synaptic Transmission Response To Glucocorticoid Response To Methylmercury Long-term Synaptic Potentiation Cellular Response To Hypoxia Response To Anesthetic Sympathetic Neuron Projection Extension Neuron Projection Extension Adaptive Thermogenesis Negative Regulation Of Skeletal Muscle Cell Differentiation	Response To Hypoxia Microglial Cell Activation Positive Regulation Of Cytokine Production Regulation Of T Cell Mediated Cytotoxicity DNA Replication DNA Repair Phagocytosis Inflammatory Response DNA Damage Response Cell Adhesion Cell Surface Receptor Signaling Pathway Learning Or Memory Positive Regulation Of Cell Population Proliferation Response To Wounding Negative Regulation Of Biosynthetic Process Glucose Mediated Signaling Pathway Astrocyte Development Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Interleukin-10 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Activated T Cell Proliferation Transcytosis Positive Regulation Of Cell Differentiation Positive Regulation Of JNK Cascade Astrocyte Activation Regulation Of Synaptic Plasticity Regulation Of Inflammatory Response Induction Of Positive Chemotaxis Positive Regulation Of DNA Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucose Stimulus Positive Regulation Of Monocyte Chemotactic Protein-1 Production Protein Localization To Membrane Regulation Of Spontaneous Synaptic Transmission Transport Across Blood-brain Barrier Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Long-term Synaptic Depression Regulation Of P38MAPK Cascade Positive Regulation Of P38MAPK Cascade Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Blood Circulation Positive Regulation Of Endothelin Production Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Response To Amyloid-beta Cellular Response To Amyloid-beta Positive Regulation Of DNA-templated DNA Replication Positive Regulation Of Monocyte Extravasation Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Double-strand Break Repair Positive Regulation Of Dendritic Cell Differentiation
Pathways		Nuclear signaling by ERBB4 TAK1-dependent IKK and NF-kappa-B activation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation	TAK1-dependent IKK and NF-kappa-B activation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation
Drugs		Olopatadine Calcium N-Formylmethionine Arundic acid (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Cutaneous leishmaniasis ( 32830257) Lymphocyte count ( 22286170)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels in cardiovascular risk ( 28369058) Chronic obstructive pulmonary disease ( 33909500 30804561 28166215) Emphysema imaging phenotypes ( 26030696) FEV1 ( 30804560) Inflammatory bowel disease ( 28067908) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Percentage gas trapping ( 26030696) Prostate cancer ( 23535732) Pulmonary function ( 20010834 20010835) Pulmonary function (smoking interaction) ( 23284291) Response to Pazopanib in cancer (hepatotoxicity) ( 26546620) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Soluble receptor for advanced glycation end-product levels ( 26083729) Ulcerative colitis ( 28067908)
Interacting Genes		49 interacting genes: ADTRP AGER AGTRAP AHNAK ANXA6 APOE BCL2L2 CACYBP CALM1 CAPZA1 CEP20 CT45A5 DES DNAJC30 FBXO7 FBXW5 GFAP GUCY2D IFNB1 IL11 IMP4 IMPA1 IQGAP1 LDAF1 LNX1 MAL2 MAPT MDM2 MDM4 NDRG1 NKAPD1 PGM1 RABAC1 S100A1 S100A11 S100A2 S100A4 S100A6 S100A9 S100P S100Z SDCBP SPG21 STK38 SUGT1 TMEM239 TNIP1 TP53 VAV1	10 interacting genes: APP C3orf52 CMTM7 CREB3 HMGB1 S100A1 S100A12 S100B S100P TTR
Entrez ID		6285	177
HPRD ID		01505	02568
Ensembl ID		ENSG00000160307	ENSG00000204305
Uniprot IDs		A0A0S2Z4C5 P04271	A0A1U9X785 B4DNX3 Q101R3 Q15109
PDB IDs		1MQ1 1UWO 2H61 2M49 2PRU 3CZT 3D0Y 3D10 3HCM 4XYN 5CSF 5CSI 5CSJ 5CSN 5D7F	2E5E 2ENS 2L7U 2LE9 2LMB 2M1K 2MJW 2MOV 3CJJ 3O3U 4LP4 4LP5 4OF5 4OFV 4OI7 4OI8 4P2Y 4XYN 4YBH 5D7F 6VXG 6XQ1 6XQ3 6XQ5 6XQ6 6XQ7 6XQ8 6XQ9 7LML 7LMW 8I9M
Enriched GO Terms of Interacting Partners?		S100 Protein Binding Calcium-dependent Protein Binding Identical Protein Binding Calcium Ion Binding DNA Damage Response, Signal Transduction By P53 Class Mediator Astrocyte Development Cellular Response To Actinomycin D Transition Metal Ion Binding Cytoplasm Response To Actinomycin D Disordered Domain Specific Binding Protein Binding Cellular Response To UV-C Signal Transduction In Response To DNA Damage Cell Activation Regulation Of Intracellular Signal Transduction Endothelial Cell Migration Extracellular Exosome Protein Homodimerization Activity Negative Regulation Of Cellular Component Organization Response To Hypoxia Leukocyte Activation Signal Transduction By P53 Class Mediator Lipoprotein Particle Binding Response To Decreased Oxygen Levels Cadherin Binding Atrial Septum Development Regulation Of Synaptic Plasticity Signal Transduction Regulation Of DNA Replication Response To Metal Ion Cellular Response To Antibiotic Response To Oxygen Levels Negative Regulation Of Long-term Synaptic Potentiation RAGE Receptor Binding Extracellular Region Cellular Response To Hypoxia Cytosol Response To UV-C Regulation Of Long-term Synaptic Depression Regulation Of Blood Circulation Glial Cell Development Regulation Of Voltage-gated Calcium Channel Activity Cellular Response To Decreased Oxygen Levels Transcription Repressor Complex SCF Ubiquitin Ligase Complex	RAGE Receptor Binding Calcium-dependent Protein Binding Positive Regulation Of Monocyte Chemotaxis Chemotaxis Regulation Of Monocyte Chemotaxis Locomotion Identical Protein Binding Endothelial Cell Migration Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Protein Homodimerization Activity S100 Protein Binding Extracellular Region Secretory Granule Lumen Myeloid Leukocyte Activation Transition Metal Ion Binding Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Sprouting Angiogenesis Chemoattractant Activity Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Chemotaxis Regulation Of System Process Leukocyte Activation Regulation Of Leukocyte Migration Calcium Ion Binding Positive Chemotaxis Cell Activation Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Defense Response To Fungus Response To Fungus Positive Regulation Of Interleukin-1 Beta Production Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Regulation Of Sprouting Angiogenesis Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Deacetylase Activity Macrophage Activation Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Interleukin-1 Production Positive Regulation Of Chemokine Production Extracellular Space Acetylcholine Receptor Activator Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?