S100B and CAPZA1

Number of citations of the paper that reports this interaction (PubMedID 12470955)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		S100B	CAPZA1
Description		S100 calcium binding protein B	capping actin protein of muscle Z-line subunit alpha 1
Image
GO Annotations	Cellular Component	Ruffle Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Microtubule Cytoskeleton Ciliary Basal Body Neuronal Cell Body Perinuclear Region Of Cytoplasm	Extracellular Region Cytoplasm Cytosol Cytoskeleton F-actin Capping Protein Complex Actin Cytoskeleton Cortical Cytoskeleton Extracellular Exosome WASH Complex
	Molecular Function	Signaling Receptor Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Metal Ion Binding Tau Protein Binding Calcium-dependent Protein Binding RAGE Receptor Binding	Actin Binding Protein Binding Cadherin Binding Actin Filament Binding
	Biological Process	Cell Adhesion Axonogenesis Central Nervous System Development Learning Or Memory Memory Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Myelination Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Ethanol Positive Regulation Of Neuron Differentiation Regulation Of Neuronal Synaptic Plasticity Astrocyte Differentiation Positive Regulation Of Synaptic Transmission Response To Glucocorticoid Response To Methylmercury Long-term Synaptic Potentiation Cellular Response To Hypoxia Response To Anesthetic Sympathetic Neuron Projection Extension Neuron Projection Extension Adaptive Thermogenesis Negative Regulation Of Skeletal Muscle Cell Differentiation	Actin Cytoskeleton Organization Cell Junction Assembly Barbed-end Actin Filament Capping Actin Filament Capping Protein-containing Complex Assembly
Pathways		Nuclear signaling by ERBB4 TAK1-dependent IKK and NF-kappa-B activation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation	MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Advanced glycosylation endproduct receptor signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Sensory processing of sound by inner hair cells of the cochlea Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
Drugs		Olopatadine Calcium N-Formylmethionine Arundic acid (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Cutaneous leishmaniasis ( 32830257) Lymphocyte count ( 22286170)	Blood pressure ( 21572416) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Cortical volume ( 32963231) Diastolic blood pressure ( 26390057 27618452 27841878 28739976 30487518) Height ( 25282103) Hypertension ( 30487518) Intraocular pressure ( 29785010 29617998) Mean arterial pressure ( 30487518) Mean platelet volume ( 32888494) Platelet count ( 27863252) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 30487518 28739976 27841878 27618452) Total cholesterol levels ( 30275531)
Interacting Genes		49 interacting genes: ADTRP AGER AGTRAP AHNAK ANXA6 APOE BCL2L2 CACYBP CALM1 CAPZA1 CEP20 CT45A5 DES DNAJC30 FBXO7 FBXW5 GFAP GUCY2D IFNB1 IL11 IMP4 IMPA1 IQGAP1 LDAF1 LNX1 MAL2 MAPT MDM2 MDM4 NDRG1 NKAPD1 PGM1 RABAC1 S100A1 S100A11 S100A2 S100A4 S100A6 S100A9 S100P S100Z SDCBP SPG21 STK38 SUGT1 TMEM239 TNIP1 TP53 VAV1	7 interacting genes: ACTB CD2AP CEBPA S100A1 S100B SH3KBP1 UCHL5
Entrez ID		6285	829
HPRD ID		01505	03347
Ensembl ID		ENSG00000160307	ENSG00000116489
Uniprot IDs		A0A0S2Z4C5 P04271	P52907
PDB IDs		1MQ1 1UWO 2H61 2M49 2PRU 3CZT 3D0Y 3D10 3HCM 4XYN 5CSF 5CSI 5CSJ 5CSN 5D7F	1MQ1 1MWN 7T5Q 8F8Q
Enriched GO Terms of Interacting Partners?		S100 Protein Binding Calcium-dependent Protein Binding Identical Protein Binding Calcium Ion Binding DNA Damage Response, Signal Transduction By P53 Class Mediator Astrocyte Development Cellular Response To Actinomycin D Transition Metal Ion Binding Cytoplasm Response To Actinomycin D Disordered Domain Specific Binding Protein Binding Cellular Response To UV-C Signal Transduction In Response To DNA Damage Cell Activation Regulation Of Intracellular Signal Transduction Endothelial Cell Migration Extracellular Exosome Protein Homodimerization Activity Negative Regulation Of Cellular Component Organization Response To Hypoxia Leukocyte Activation Signal Transduction By P53 Class Mediator Lipoprotein Particle Binding Response To Decreased Oxygen Levels Cadherin Binding Atrial Septum Development Regulation Of Synaptic Plasticity Signal Transduction Regulation Of DNA Replication Response To Metal Ion Cellular Response To Antibiotic Response To Oxygen Levels Negative Regulation Of Long-term Synaptic Potentiation RAGE Receptor Binding Extracellular Region Cellular Response To Hypoxia Cytosol Response To UV-C Regulation Of Long-term Synaptic Depression Regulation Of Blood Circulation Glial Cell Development Regulation Of Voltage-gated Calcium Channel Activity Cellular Response To Decreased Oxygen Levels Transcription Repressor Complex SCF Ubiquitin Ligase Complex	Regulation Of Multicellular Organismal Process S100 Protein Binding Cell-cell Junction Maintenance Of Blood-brain Barrier Regulation Of Multicellular Organismal Development Regulation Of Developmental Process Substantia Nigra Development Protein-containing Complex Tau Protein Binding Positive Regulation Of Multicellular Organismal Process Identical Protein Binding Positive Regulation Of Immune System Process Neural Nucleus Development Positive Regulation Of Cell Activation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Calcium-dependent Protein Binding Actin Filament Structural Constituent Of Cytoskeleton Multicellular Organismal-level Homeostasis Regulation Of Norepinephrine Uptake Response To Vitamin B2 Liver Development C/EBP Complex Ruffle SH3 Domain Binding Positive Regulation Of Developmental Process Memory Developmental Cell Growth Positive Regulation Of DNA Repair Nuclear Matrix Transporter Regulator Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Response To Glucocorticoid Regulation Of Cell Shape Developmental Growth Involved In Morphogenesis Regulation Of Transepithelial Transport Axonogenesis Regulation Of Cell Activation White Fat Cell Proliferation Response To Corticosteroid Response To Hormone System Process Renal Albumin Absorption Response To Glial Cell Derived Neurotrophic Factor Negative Regulation Of Cell Differentiation Protein Localization To Adherens Junction Dense Body
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