S100B and AHNAK

Number of citations of the paper that reports this interaction (PMID 11312263)
21

Data Source:
HPRD (in vivo, in vitro)

		S100B	AHNAK
Gene Name		S100 calcium binding protein B	AHNAK nucleoprotein
Image
Gene Ontology Annotations	Cellular Component	Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Neuronal Cell Body Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane T-tubule Vesicle Sarcolemma Costamere Cell-cell Contact Zone Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Tau Protein Binding Calcium-dependent Protein Binding RAGE Receptor Binding	Protein Binding S100 Protein Binding Poly(A) RNA Binding Structural Molecule Activity Conferring Elasticity
	Biological Process	Axonogenesis Central Nervous System Development Learning Or Memory Memory Cell Proliferation Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Neuronal Synaptic Plasticity Astrocyte Differentiation Response To Glucocorticoid Response To Methylmercury Long-term Synaptic Potentiation Cellular Response To Hypoxia Negative Regulation Of Skeletal Muscle Cell Differentiation	Regulation Of RNA Splicing Protein Oligomerization Regulation Of Voltage-gated Calcium Channel Activity
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Signaling by ERBB4 MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Nuclear signaling by ERBB4 Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs		Olopatadine Calcium N-Formylmethionine (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide
Diseases
GWAS		Lymphocyte counts ( 22286170)	Chronic obstructive pulmonary disease-related biomarkers ( 23144326)
Protein-Protein Interactions		27 interactors: AGER AHNAK ANXA6 CACYBP CALM1 CAPZA1 DES GFAP GUCY2D IMPA1 IQGAP1 MAPT MDM2 NDRG1 PGM1 S100A1 S100A11 S100A2 S100A4 S100A6 S100P SPG21 STK38 SUGT1 TNIP1 TP53 VAV1	8 interactors: AKT1 CDKN2A EGFR KLHL40 NOL9 POT1 S100B XRCC4
Entrez ID		6285	79026
HPRD ID		01505	14684
Ensembl ID			ENSG00000124942
Uniprot IDs		P04271	B4DTV0 Q09666 Q9BVU3
PDB IDs		1MQ1 1UWO 2H61 2PRU 3CZT 3D0Y 3D10 3HCM	4DRW 4FTG 4HRG
Enriched GO Terms of Interacting Partners?		Regulation Of Voltage-gated Calcium Channel Activity Cellular Response To Light Stimulus Cellular Response To Radiation Cellular Response To Stimulus Response To Stimulus Signal Transduction Response To Metal Ion Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune System Process Signaling Regulation Of Cation Channel Activity Cell Communication DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Wounding Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Immune Response-regulating Signaling Pathway Response To Inorganic Substance Glycogen Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Innate Immune Response Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Polysaccharide Catabolic Process Response To Calcium Ion Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of DNA Replication Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Rhodopsin Mediated Signaling Pathway Immune Response Response To Growth Factor Response To Light Stimulus Energy Reserve Metabolic Process Defense Response Regulation Of Ion Transmembrane Transporter Activity Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Regulation Of Transmembrane Transporter Activity Nervous System Development Positive Regulation Of Cation Channel Activity Regulation Of Cellular Process Immune Response-regulating Cell Surface Receptor Signaling Pathway	Response To UV-A Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Response To Epidermal Growth Factor Stimulus Glial Cell Differentiation Response To Epidermal Growth Factor Positive Regulation Of Vasoconstriction Regulation Of Apoptotic Process Regulation Of Cell Proliferation Positive Regulation Of Catalytic Activity Gliogenesis Regulation Of Cell Death Mitotic Cell Cycle Phase Transition Regulation Of Nitric-oxide Synthase Activity Cell Cycle Phase Transition Astrocyte Differentiation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Proliferation Positive Regulation Of Cell Cycle Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Transferase Activity Regulation Of Vasoconstriction Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of DNA Replication Cellular Response To Mechanical Stimulus Apoptotic Mitochondrial Changes Response To Abiotic Stimulus Regulation Of Oxidoreductase Activity Regulation Of Intracellular Transport Alkanesulfonate Metabolic Process Glycogen Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of DNA Strand Elongation Response To Radiation Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Catalytic Activity Regulation Of Fibroblast Proliferation Cellular Response To Hypoxia Positive Regulation Of Signal Transduction Cellular Response To Decreased Oxygen Levels In Utero Embryonic Development Glial Cell Development Immune Response Cellular Response To Oxygen Levels Positive Regulation Of Synaptic Transmission Reactive Oxygen Species Metabolic Process
Tagcloud ?		accessory antigens areas brings cd11c cd40 cd83 cd86 continually cytological dcs dec endocytic initiate interdigitating invariant lymphoid maintains migrate migratory multilectin patch periphery peyer pick recirculate resident speculate uncharacterized	100a6 a9 aldehyde caveolin cytoskeleton discover employing esi exactive fgr grades initiate introduce itraq meningeal meningiomas mgs opportunities originating phosphohistidine platforms proteomic proteomics quadrupole quite s100 tof transgelin vinculin
Tagcloud (Difference) ?		accessory antigens areas brings cd11c cd40 cd83 cd86 continually cytological dcs dec endocytic interdigitating invariant lymphoid maintains migrate migratory multilectin patch periphery peyer pick recirculate resident speculate uncharacterized	100a6 a9 aldehyde caveolin cytoskeleton discover employing esi exactive fgr grades introduce itraq meningeal meningiomas mgs opportunities originating phosphohistidine platforms proteomic proteomics quadrupole quite s100 tof transgelin vinculin
Tagcloud (Intersection) ?		initiate