S100B and SUGT1

Number of citations of the paper that reports this interaction (PubMedID 12746458)
0

Data Source:
HPRD (in vitro)

		S100B	SUGT1
Description		S100 calcium binding protein B	SGT1 assembly cochaperone of MIS12 kinetochore complex
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GO Annotations	Cellular Component	Ruffle Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Microtubule Cytoskeleton Ciliary Basal Body Neuronal Cell Body Perinuclear Region Of Cytoplasm	Ubiquitin Ligase Complex Kinetochore Nucleus Cytoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	Signaling Receptor Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Metal Ion Binding Tau Protein Binding Calcium-dependent Protein Binding RAGE Receptor Binding	Protein Binding Protein-folding Chaperone Binding LncRNA Binding
	Biological Process	Cell Adhesion Axonogenesis Central Nervous System Development Learning Or Memory Memory Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Myelination Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Ethanol Positive Regulation Of Neuron Differentiation Regulation Of Neuronal Synaptic Plasticity Astrocyte Differentiation Positive Regulation Of Synaptic Transmission Response To Glucocorticoid Response To Methylmercury Long-term Synaptic Potentiation Cellular Response To Hypoxia Response To Anesthetic Sympathetic Neuron Projection Extension Neuron Projection Extension Adaptive Thermogenesis Negative Regulation Of Skeletal Muscle Cell Differentiation	Spindle Organization Skeletal Muscle Satellite Cell Proliferation Regulation Of Protein Stability Kinetochore Assembly
Pathways		Nuclear signaling by ERBB4 TAK1-dependent IKK and NF-kappa-B activation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation	The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs		Olopatadine Calcium N-Formylmethionine Arundic acid (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Cutaneous leishmaniasis ( 32830257) Lymphocyte count ( 22286170)
Interacting Genes		49 interacting genes: ADTRP AGER AGTRAP AHNAK ANXA6 APOE BCL2L2 CACYBP CALM1 CAPZA1 CEP20 CT45A5 DES DNAJC30 FBXO7 FBXW5 GFAP GUCY2D IFNB1 IL11 IMP4 IMPA1 IQGAP1 LDAF1 LNX1 MAL2 MAPT MDM2 MDM4 NDRG1 NKAPD1 PGM1 RABAC1 S100A1 S100A11 S100A2 S100A4 S100A6 S100A9 S100P S100Z SDCBP SPG21 STK38 SUGT1 TMEM239 TNIP1 TP53 VAV1	18 interacting genes: BUB3 CEBPA CSNK2A1 DSN1 FNDC3B HSP90AA1 HSPA4 MIS12 NR4A1 NSL1 PAXIP1 PLK1 PMF1 PTGER4 S100A6 S100B S100P SKP1
Entrez ID		6285	10910
HPRD ID		01505	09160
Ensembl ID		ENSG00000160307	ENSG00000165416
Uniprot IDs		A0A0S2Z4C5 P04271	A8K7W3 B4DYC6 Q9Y2Z0
PDB IDs		1MQ1 1UWO 2H61 2M49 2PRU 3CZT 3D0Y 3D10 3HCM 4XYN 5CSF 5CSI 5CSJ 5CSN 5D7F	1RL1
Enriched GO Terms of Interacting Partners?		S100 Protein Binding Calcium-dependent Protein Binding Identical Protein Binding Calcium Ion Binding DNA Damage Response, Signal Transduction By P53 Class Mediator Astrocyte Development Cellular Response To Actinomycin D Transition Metal Ion Binding Cytoplasm Response To Actinomycin D Disordered Domain Specific Binding Protein Binding Cellular Response To UV-C Signal Transduction In Response To DNA Damage Cell Activation Regulation Of Intracellular Signal Transduction Endothelial Cell Migration Extracellular Exosome Protein Homodimerization Activity Negative Regulation Of Cellular Component Organization Response To Hypoxia Leukocyte Activation Signal Transduction By P53 Class Mediator Lipoprotein Particle Binding Response To Decreased Oxygen Levels Cadherin Binding Atrial Septum Development Regulation Of Synaptic Plasticity Signal Transduction Regulation Of DNA Replication Response To Metal Ion Cellular Response To Antibiotic Response To Oxygen Levels Negative Regulation Of Long-term Synaptic Potentiation RAGE Receptor Binding Extracellular Region Cellular Response To Hypoxia Cytosol Response To UV-C Regulation Of Long-term Synaptic Depression Regulation Of Blood Circulation Glial Cell Development Regulation Of Voltage-gated Calcium Channel Activity Cellular Response To Decreased Oxygen Levels Transcription Repressor Complex SCF Ubiquitin Ligase Complex	MIS12/MIND Type Complex Outer Kinetochore Attachment Of Spindle Microtubules To Kinetochore Chromosome Segregation Chromosome, Centromeric Region Kinetochore Spindle Pole Protein Localization To Organelle Chromosome Cell Division Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Nuclear Chromosome Segregation Nucleus Negative Regulation Of Cell Cycle Identical Protein Binding Positive Regulation Of Protein Catabolic Process Regulation Of Chromosome Separation Calcium-dependent Protein Binding Endothelial Cell Migration S100 Protein Binding Regulation Of DNA Metabolic Process Nucleoplasm Protein Localization To Chromosome Positive Regulation Of Catabolic Process Chaperone-mediated Protein Complex Assembly Memory Protein Import Into Mitochondrial Matrix Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Hormone Regulation Of DNA Recombination Regulation Of Chromosome Segregation PcG Protein Complex Establishment Of Protein Localization To Organelle Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break Chromosome Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Apoptotic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Catabolic Process Regulation Of Programmed Cell Death ATP-dependent Protein Folding Chaperone Regulation Of Cell Cycle Protein Homodimerization Activity Positive Regulation Of Inflammatory Response Protein Localization To Mitochondrion Negative Regulation Of Mitotic Nuclear Division Regulation Of Ubiquitin-dependent Protein Catabolic Process
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