S100B and IMPA1

Number of citations of the paper that reports this interaction (PMID 19593677)
4

Data Source:
BioGRID (pull down, imaging technique, enzymatic study)

		S100B	IMPA1
Gene Name		S100 calcium binding protein B	inositol(myo)-1(or 4)-monophosphatase 1
Image
Gene Ontology Annotations	Cellular Component	Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Neuronal Cell Body Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Tau Protein Binding Calcium-dependent Protein Binding RAGE Receptor Binding	Magnesium Ion Binding Inositol Monophosphate 1-phosphatase Activity Manganese Ion Binding Lithium Ion Binding Identical Protein Binding Protein Homodimerization Activity Inositol Monophosphate 3-phosphatase Activity Inositol Monophosphate 4-phosphatase Activity Inositol Monophosphate Phosphatase Activity
	Biological Process	Axonogenesis Central Nervous System Development Learning Or Memory Memory Cell Proliferation Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Neuronal Synaptic Plasticity Astrocyte Differentiation Response To Glucocorticoid Response To Methylmercury Long-term Synaptic Potentiation Cellular Response To Hypoxia Negative Regulation Of Skeletal Muscle Cell Differentiation	Inositol Biosynthetic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Signal Transduction Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation Inositol Phosphate Dephosphorylation
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Signaling by ERBB4 MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Nuclear signaling by ERBB4 Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Synthesis of IP2, IP, and Ins in the cytosol Inositol phosphate metabolism
Drugs		Olopatadine Calcium N-Formylmethionine (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide	Lithium L-Myo-Inositol-1-Phosphate
Diseases
GWAS		Lymphocyte counts ( 22286170)	Ovarian cancer ( 23535730)
Protein-Protein Interactions		27 interactors: AGER AHNAK ANXA6 CACYBP CALM1 CAPZA1 DES GFAP GUCY2D IMPA1 IQGAP1 MAPT MDM2 NDRG1 PGM1 S100A1 S100A11 S100A2 S100A4 S100A6 S100P SPG21 STK38 SUGT1 TNIP1 TP53 VAV1	4 interactors: CALB1 IMPA2 NXF1 S100B
Entrez ID		6285	3612
HPRD ID		01505	03641
Ensembl ID			ENSG00000133731
Uniprot IDs		P04271	P29218
PDB IDs		1MQ1 1UWO 2H61 2PRU 3CZT 3D0Y 3D10 3HCM	1AWB 1IMA 1IMB 1IMC 1IMD 1IME 1IMF 2HHM 4AS4
Enriched GO Terms of Interacting Partners?		Regulation Of Voltage-gated Calcium Channel Activity Cellular Response To Light Stimulus Cellular Response To Radiation Cellular Response To Stimulus Response To Stimulus Signal Transduction Response To Metal Ion Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune System Process Signaling Regulation Of Cation Channel Activity Cell Communication DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Wounding Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Immune Response-regulating Signaling Pathway Response To Inorganic Substance Glycogen Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Innate Immune Response Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Polysaccharide Catabolic Process Response To Calcium Ion Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of DNA Replication Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Rhodopsin Mediated Signaling Pathway Immune Response Response To Growth Factor Response To Light Stimulus Energy Reserve Metabolic Process Defense Response Regulation Of Ion Transmembrane Transporter Activity Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Regulation Of Transmembrane Transporter Activity Nervous System Development Positive Regulation Of Cation Channel Activity Regulation Of Cellular Process Immune Response-regulating Cell Surface Receptor Signaling Pathway	Memory Metanephric Connecting Tubule Development Regulation Of Synaptic Plasticity Negative Regulation Of Skeletal Muscle Cell Differentiation Metanephric Part Of Ureteric Bud Development Learning Or Memory Cognition Metanephric Distal Convoluted Tubule Development Regulation Of Synaptic Transmission Metanephric Distal Tubule Development Inositol Biosynthetic Process Poly(A)+ MRNA Export From Nucleus Response To Methylmercury Metanephric Collecting Duct Development Distal Tubule Development Inositol Phosphate Dephosphorylation Phosphorylated Carbohydrate Dephosphorylation Single-organism Behavior Collecting Duct Development Short-term Memory Metanephric Nephron Tubule Development Regulation Of Skeletal Muscle Cell Differentiation Negative Regulation Of Skeletal Muscle Tissue Development Behavior Inositol Metabolic Process Retina Layer Formation Metanephric Epithelium Development Metanephros Morphogenesis Astrocyte Differentiation Long-term Memory Negative Regulation Of Striated Muscle Tissue Development Long-term Synaptic Potentiation Inositol Phosphate Metabolic Process Negative Regulation Of Muscle Organ Development Alcohol Catabolic Process Neural Retina Development Retina Morphogenesis In Camera-type Eye Regulation Of Neuronal Synaptic Plasticity MRNA Export From Nucleus Regulation Of Skeletal Muscle Tissue Development
Tagcloud ?		accessory antigens areas brings cd11c cd40 cd83 cd86 continually cytological dcs dec endocytic initiate interdigitating invariant lymphoid maintains migrate migratory multilectin patch periphery peyer pick recirculate resident speculate uncharacterized
Tagcloud (Difference) ?		accessory antigens areas brings cd11c cd40 cd83 cd86 continually cytological dcs dec endocytic initiate interdigitating invariant lymphoid maintains migrate migratory multilectin patch periphery peyer pick recirculate resident speculate uncharacterized
Tagcloud (Intersection) ?