S100B and IMPA1

Number of citations of the paper that reports this interaction (PubMedID 19593677)
49

Data Source:
BioGRID (pull down, imaging technique, enzymatic study)

		S100B	IMPA1
Description		S100 calcium binding protein B	inositol monophosphatase 1
Image
GO Annotations	Cellular Component	Ruffle Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Microtubule Cytoskeleton Ciliary Basal Body Neuronal Cell Body Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol
	Molecular Function	Signaling Receptor Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Metal Ion Binding Tau Protein Binding Calcium-dependent Protein Binding RAGE Receptor Binding	Magnesium Ion Binding Glucose-6-phosphatase Activity Protein Binding Glucose-1-phosphatase Activity Inositol Monophosphate 1-phosphatase Activity Hydrolase Activity Manganese Ion Binding Lithium Ion Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Glycerol-2-phosphatase Activity Inositol Monophosphate 3-phosphatase Activity Inositol Monophosphate 4-phosphatase Activity Inositol Monophosphate Phosphatase Activity Fructose-1-phosphatase Activity
	Biological Process	Cell Adhesion Axonogenesis Central Nervous System Development Learning Or Memory Memory Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Myelination Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Ethanol Positive Regulation Of Neuron Differentiation Regulation Of Neuronal Synaptic Plasticity Astrocyte Differentiation Positive Regulation Of Synaptic Transmission Response To Glucocorticoid Response To Methylmercury Long-term Synaptic Potentiation Cellular Response To Hypoxia Response To Anesthetic Sympathetic Neuron Projection Extension Neuron Projection Extension Adaptive Thermogenesis Negative Regulation Of Skeletal Muscle Cell Differentiation	Inositol Metabolic Process Inositol Biosynthetic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Signal Transduction Phosphatidylinositol Phosphate Biosynthetic Process
Pathways		Nuclear signaling by ERBB4 TAK1-dependent IKK and NF-kappa-B activation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation	Synthesis of IP2, IP, and Ins in the cytosol
Drugs		Olopatadine Calcium N-Formylmethionine Arundic acid (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	Lithium cation L-Myo-Inositol-1-Phosphate Lithium citrate Lithium succinate Lithium carbonate
Diseases
GWAS		Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Cutaneous leishmaniasis ( 32830257) Lymphocyte count ( 22286170)	Ovarian cancer ( 23535730)
Interacting Genes		49 interacting genes: ADTRP AGER AGTRAP AHNAK ANXA6 APOE BCL2L2 CACYBP CALM1 CAPZA1 CEP20 CT45A5 DES DNAJC30 FBXO7 FBXW5 GFAP GUCY2D IFNB1 IL11 IMP4 IMPA1 IQGAP1 LDAF1 LNX1 MAL2 MAPT MDM2 MDM4 NDRG1 NKAPD1 PGM1 RABAC1 S100A1 S100A11 S100A2 S100A4 S100A6 S100A9 S100P S100Z SDCBP SPG21 STK38 SUGT1 TMEM239 TNIP1 TP53 VAV1	3 interacting genes: CALB1 NXF1 S100B
Entrez ID		6285	3612
HPRD ID		01505	03641
Ensembl ID		ENSG00000160307	ENSG00000133731
Uniprot IDs		A0A0S2Z4C5 P04271	A0A140VJL8 P29218
PDB IDs		1MQ1 1UWO 2H61 2M49 2PRU 3CZT 3D0Y 3D10 3HCM 4XYN 5CSF 5CSI 5CSJ 5CSN 5D7F	1AWB 1IMA 1IMB 1IMC 1IMD 1IME 1IMF 2HHM 4AS4 6GIU 6GJ0 6ZK0 7VCE
Enriched GO Terms of Interacting Partners?		S100 Protein Binding Calcium-dependent Protein Binding Identical Protein Binding Calcium Ion Binding DNA Damage Response, Signal Transduction By P53 Class Mediator Astrocyte Development Cellular Response To Actinomycin D Transition Metal Ion Binding Cytoplasm Response To Actinomycin D Disordered Domain Specific Binding Protein Binding Cellular Response To UV-C Signal Transduction In Response To DNA Damage Cell Activation Regulation Of Intracellular Signal Transduction Endothelial Cell Migration Extracellular Exosome Protein Homodimerization Activity Negative Regulation Of Cellular Component Organization Response To Hypoxia Leukocyte Activation Signal Transduction By P53 Class Mediator Lipoprotein Particle Binding Response To Decreased Oxygen Levels Cadherin Binding Atrial Septum Development Regulation Of Synaptic Plasticity Signal Transduction Regulation Of DNA Replication Response To Metal Ion Cellular Response To Antibiotic Response To Oxygen Levels Negative Regulation Of Long-term Synaptic Potentiation RAGE Receptor Binding Extracellular Region Cellular Response To Hypoxia Cytosol Response To UV-C Regulation Of Long-term Synaptic Depression Regulation Of Blood Circulation Glial Cell Development Regulation Of Voltage-gated Calcium Channel Activity Cellular Response To Decreased Oxygen Levels Transcription Repressor Complex SCF Ubiquitin Ligase Complex	Metanephric Connecting Tubule Development Calcium Ion Binding Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Memory Metanephric Part Of Ureteric Bud Development Regulation Of Synaptic Plasticity Learning Or Memory Cognition Vitamin D Binding Metanephric Distal Convoluted Tubule Development Calcium Ion Binding Involved In Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Response To Anesthetic Response To Methylmercury Sympathetic Neuron Projection Extension Neuronal Cell Body Negative Regulation Of Skeletal Muscle Cell Differentiation Nuclear RNA Export Factor Complex Cuticular Plate Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Short-term Memory Metanephric Collecting Duct Development Metanephric Tubule Development Collecting Duct Development Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Metanephric Nephron Tubule Development Modulation Of Chemical Synaptic Transmission RAGE Receptor Binding S100 Protein Binding Nuclear Inclusion Body Transcription Export Complex Metanephric Epithelium Development Calyx Of Held Positive Regulation Of Myelination Response To Auditory Stimulus Calcium Ion Binding Nephron Tubule Development Regulation Of Skeletal Muscle Cell Differentiation Adaptive Thermogenesis Poly(A)+ MRNA Export From Nucleus Renal Tubule Development Retina Layer Formation Presynaptic Cytosol Postsynaptic Cytosol Astrocyte Differentiation Cochlea Development Long-term Memory Terminal Bouton Stereocilium Nervous System Process Regulation Of Myelination Tau Protein Binding
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