S100B and ANXA6

Number of citations of the paper that reports this interaction (PubMedID 9883272)
0

Data Source:
HPRD (in vitro)

		S100B	ANXA6
Description		S100 calcium binding protein B	annexin A6
Image
GO Annotations	Cellular Component	Ruffle Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Cilium Microtubule Cytoskeleton Ciliary Basal Body Neuronal Cell Body Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Mitochondrion Lysosomal Membrane Plasma Membrane Focal Adhesion Vesicle Membrane Membrane Extracellular Matrix Late Endosome Membrane Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Metal Ion Binding Tau Protein Binding Calcium-dependent Protein Binding RAGE Receptor Binding	Phosphatidylserine Binding Calcium Ion Binding Protein Binding GTP Binding Calcium-dependent Phospholipid Binding Lipid Binding Ligand-gated Monoatomic Ion Channel Activity Cholesterol Binding Identical Protein Binding Calcium-dependent Protein Binding
	Biological Process	Cell Adhesion Axonogenesis Central Nervous System Development Learning Or Memory Memory Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Myelination Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Ethanol Positive Regulation Of Neuron Differentiation Regulation Of Neuronal Synaptic Plasticity Astrocyte Differentiation Positive Regulation Of Synaptic Transmission Response To Glucocorticoid Response To Methylmercury Long-term Synaptic Potentiation Cellular Response To Hypoxia Response To Anesthetic Sympathetic Neuron Projection Extension Neuron Projection Extension Adaptive Thermogenesis Negative Regulation Of Skeletal Muscle Cell Differentiation	Calcium Ion Transport Regulation Of Muscle Contraction Monoatomic Ion Transmembrane Transport Negative Regulation Of Sequestering Of Calcium Ion Mitochondrial Calcium Ion Homeostasis Apoptotic Signaling Pathway
Pathways		Nuclear signaling by ERBB4 TAK1-dependent IKK and NF-kappa-B activation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation	Smooth Muscle Contraction
Drugs		Olopatadine Calcium N-Formylmethionine Arundic acid (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Cutaneous leishmaniasis ( 32830257) Lymphocyte count ( 22286170)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) Lymphocyte count ( 32888494) Psoriasis ( 25574825 25903422) Psoriatic arthritis ( 26626624)
Interacting Genes		49 interacting genes: ADTRP AGER AGTRAP AHNAK ANXA6 APOE BCL2L2 CACYBP CALM1 CAPZA1 CEP20 CT45A5 DES DNAJC30 FBXO7 FBXW5 GFAP GUCY2D IFNB1 IL11 IMP4 IMPA1 IQGAP1 LDAF1 LNX1 MAL2 MAPT MDM2 MDM4 NDRG1 NKAPD1 PGM1 RABAC1 S100A1 S100A11 S100A2 S100A4 S100A6 S100A9 S100P S100Z SDCBP SPG21 STK38 SUGT1 TMEM239 TNIP1 TP53 VAV1	19 interacting genes: A2M CDC73 CEBPA CR2 ERBB2 IL16 LINC00632 LINC01554 MLH1 MTNR1B OGT PDE4B RASA1 RHOU S100A1 S100B SMURF1 SNCA TPD52
Entrez ID		6285	309
HPRD ID		01505	00231
Ensembl ID		ENSG00000160307	ENSG00000197043
Uniprot IDs		A0A0S2Z4C5 P04271	A0A0S2Z2Z6 A0A0S2Z377 P08133
PDB IDs		1MQ1 1UWO 2H61 2M49 2PRU 3CZT 3D0Y 3D10 3HCM 4XYN 5CSF 5CSI 5CSJ 5CSN 5D7F	1M9I
Enriched GO Terms of Interacting Partners?		S100 Protein Binding Calcium-dependent Protein Binding Identical Protein Binding Calcium Ion Binding DNA Damage Response, Signal Transduction By P53 Class Mediator Astrocyte Development Cellular Response To Actinomycin D Transition Metal Ion Binding Cytoplasm Response To Actinomycin D Disordered Domain Specific Binding Protein Binding Cellular Response To UV-C Signal Transduction In Response To DNA Damage Cell Activation Regulation Of Intracellular Signal Transduction Endothelial Cell Migration Extracellular Exosome Protein Homodimerization Activity Negative Regulation Of Cellular Component Organization Response To Hypoxia Leukocyte Activation Signal Transduction By P53 Class Mediator Lipoprotein Particle Binding Response To Decreased Oxygen Levels Cadherin Binding Atrial Septum Development Regulation Of Synaptic Plasticity Signal Transduction Regulation Of DNA Replication Response To Metal Ion Cellular Response To Antibiotic Response To Oxygen Levels Negative Regulation Of Long-term Synaptic Potentiation RAGE Receptor Binding Extracellular Region Cellular Response To Hypoxia Cytosol Response To UV-C Regulation Of Long-term Synaptic Depression Regulation Of Blood Circulation Glial Cell Development Regulation Of Voltage-gated Calcium Channel Activity Cellular Response To Decreased Oxygen Levels Transcription Repressor Complex SCF Ubiquitin Ligase Complex	Regulation Of Multicellular Organismal Process Regulation Of Immune System Process Positive Regulation Of Multicellular Organismal Process Signaling Receptor Binding Calcium-dependent Protein Binding Cellular Developmental Process Negative Regulation Of Complement Activation Signal Transduction Regulation Of Developmental Process Cellular Response To Epinephrine Stimulus S100 Protein Binding Response To Epinephrine Regulation Of Cell Morphogenesis Regulation Of Anatomical Structure Morphogenesis Regulation Of Complement Activation Leukocyte Activation Regulation Of Cell Shape Developmental Process Regulation Of Cell Activation Regulation Of Signal Transduction Cell Activation Enzyme Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Cell Surface Receptor Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein Homodimerization Activity Positive Regulation Of Inflammatory Response Regulation Of Programmed Cell Death Regulation Of Biological Quality Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Negative Regulation Of Neuron Apoptotic Process Tau Protein Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Engulfment Of Target By Autophagosome Growth Factor Binding B Cell Activation Regulation Of Humoral Immune Response Positive Regulation Of Proteolysis Carbohydrate Homeostasis Glucose Homeostasis Response To Lipid Lymphocyte Activation Negative Regulation Of Complement Activation, Lectin Pathway
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