S100B and STK38

Number of citations of the paper that reports this interaction (PMID 14661952)
32

Data Source:
HPRD (in vitro)

		S100B	STK38
Gene Name		S100 calcium binding protein B	serine/threonine kinase 38
Image
Gene Ontology Annotations	Cellular Component	Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Neuronal Cell Body Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm MLL5-L Complex
	Molecular Function	Calcium Ion Binding Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Tau Protein Binding Calcium-dependent Protein Binding RAGE Receptor Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Kinase Binding
	Biological Process	Axonogenesis Central Nervous System Development Learning Or Memory Memory Cell Proliferation Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Neuronal Synaptic Plasticity Astrocyte Differentiation Response To Glucocorticoid Response To Methylmercury Long-term Synaptic Potentiation Cellular Response To Hypoxia Negative Regulation Of Skeletal Muscle Cell Differentiation	Cellular Protein Modification Process Protein Phosphorylation Intracellular Signal Transduction Negative Regulation Of MAP Kinase Activity
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Signaling by ERBB4 MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Nuclear signaling by ERBB4 Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs		Olopatadine Calcium N-Formylmethionine (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide
Diseases
GWAS		Lymphocyte counts ( 22286170)
Protein-Protein Interactions		27 interactors: AGER AHNAK ANXA6 CACYBP CALM1 CAPZA1 DES GFAP GUCY2D IMPA1 IQGAP1 MAPT MDM2 NDRG1 PGM1 S100A1 S100A11 S100A2 S100A4 S100A6 S100P SPG21 STK38 SUGT1 TNIP1 TP53 VAV1	8 interactors: CALM1 CTDP1 HERC5 MOB2 S100B TRIM25 YWHAB YWHAZ
Entrez ID		6285	11329
HPRD ID		01505	09511
Ensembl ID			ENSG00000112079
Uniprot IDs		P04271	Q15208
PDB IDs		1MQ1 1UWO 2H61 2PRU 3CZT 3D0Y 3D10 3HCM	1PSB
Enriched GO Terms of Interacting Partners?		Regulation Of Voltage-gated Calcium Channel Activity Cellular Response To Light Stimulus Cellular Response To Radiation Cellular Response To Stimulus Response To Stimulus Signal Transduction Response To Metal Ion Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune System Process Signaling Regulation Of Cation Channel Activity Cell Communication DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Wounding Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Immune Response-regulating Signaling Pathway Response To Inorganic Substance Glycogen Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Innate Immune Response Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Polysaccharide Catabolic Process Response To Calcium Ion Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of DNA Replication Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Rhodopsin Mediated Signaling Pathway Immune Response Response To Growth Factor Response To Light Stimulus Energy Reserve Metabolic Process Defense Response Regulation Of Ion Transmembrane Transporter Activity Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Regulation Of Transmembrane Transporter Activity Nervous System Development Positive Regulation Of Cation Channel Activity Regulation Of Cellular Process Immune Response-regulating Cell Surface Receptor Signaling Pathway	Immune Response Defense Response Innate Immune Response Immune System Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Type I Interferon Production Response To Hormone Positive Regulation Of Mitochondrion Organization Response To Stress Regulation Of Protein Phosphorylation Regulation Of Intracellular Transport Response To Steroid Hormone Regulation Of Mitochondrion Organization Positive Regulation Of Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Type I Interferon Production Response To Organic Substance Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Dephosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Death Regulation Of Signal Transduction Regulation Of Viral Process Response To Glucocorticoid Defense Response To Virus Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Skeletal Muscle Cell Differentiation Golgi Reassembly Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Corticosteroid Positive Regulation Of Protein Phosphorylation Positive Regulation Of Transport Regulation Of Signaling Regulation Of Protein Kinase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of High Voltage-gated Calcium Channel Activity Intrinsic Apoptotic Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Regulation Of Kinase Activity Response To External Stimulus Negative Regulation Of Protein Dephosphorylation Histamine Secretion By Mast Cell
Tagcloud ?		accessory antigens areas brings cd11c cd40 cd83 cd86 continually cytological dcs dec endocytic initiate interdigitating invariant lymphoid maintains migrate migratory multilectin patch periphery peyer pick recirculate resident speculate uncharacterized	asymmetric axon axons cascade depend dynein establishment evolutionarily invertebrates kinases mechanistically morphogenesis ndr ndr1 ndr2 par3 pard3 perform phosphorylating polarity polarization polarized polarizing rassf5 reinforcing ser383 specification supernumerary
Tagcloud (Difference) ?		accessory antigens areas brings cd11c cd40 cd83 cd86 continually cytological dcs dec endocytic initiate interdigitating invariant lymphoid maintains migrate migratory multilectin patch periphery peyer pick recirculate resident speculate uncharacterized	asymmetric axon axons cascade depend dynein establishment evolutionarily invertebrates kinases mechanistically morphogenesis ndr ndr1 ndr2 par3 pard3 perform phosphorylating polarity polarization polarized polarizing rassf5 reinforcing ser383 specification supernumerary
Tagcloud (Intersection) ?