CDK4 and CAPN1

		CDK4	CAPN1
Description		cyclin dependent kinase 4	calpain 1
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Cytosol Bicellular Tight Junction Membrane Nuclear Membrane Cyclin D1-CDK4 Complex Cyclin D2-CDK4 Complex Cyclin D3-CDK4 Complex	Cornified Envelope Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Calpain Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Transferase Activity Cyclin Binding Protein Serine Kinase Activity	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Proliferation Cell Division Regulation Of Cell Cycle Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4 Cellular Response To Phorbol 13-acetate 12-myristate Cellular Response To Ionomycin	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Receptor Catabolic Process Regulation Of Catalytic Activity Mammary Gland Involution Self Proteolysis NMDA Selective Glutamate Receptor Signaling Pathway
Pathways		SCF(Skp2)-mediated degradation of p27/p21 Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Cyclin D associated events in G1 Ubiquitin-dependent degradation of Cyclin D Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates Cell Cycle Transcriptional regulation by RUNX2 Meiotic recombination Transcriptional regulation of granulopoiesis Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Drug-mediated inhibition of CDK4/CDK6 activity SPOP-mediated proteasomal degradation of PD-L1(CD274)	Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		Purvalanol Alvocidib Palbociclib Ribociclib Abemaciclib Fostamatinib Trilaciclib	4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Diseases		Malignant melanoma Glioma Cervical cancer
GWAS		Brain morphology (MOSTest) ( 32665545) Celiac disease or Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 24390342 30423114)	Urate levels ( 31578528)
Interacting Genes		136 interacting genes: AGAP2 AKT1 ANKRD12 ANXA7 APLP1 APP ARAF ARID4A ARNT ATP5F1B BAG6 BCL11A BECN1 BIRC5 BMPR1B BRCA1 CAMK1 CAPNS1 CCND1 CCND2 CCND3 CCNE1 CD44 CDC37 CDC45 CDC6 CDC7 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CDKN2D CEBPA CIB1 CNOT7 CNTN2 DAZAP2 DDAH2 DUSP9 EIF4EBP2 EPHA2 ERBB2 FARP2 FBXO8 FGFR4 FOXM1 FZR1 GLIS2 GRM1 H1-0 H1-1 H1-3 HGF HIF1A HMGXB3 HOOK1 HSP90AB1 IFI27 IGF1R IKZF3 IL15RA INCA1 KDELR2 LATS2 LNX2 LUC7L2 MAP2K3 MAP2K5 MAP3K5 MAPK14 MAPRE2 MARCKS MCM2 MDM4 MET MYOD1 MZF1 NCOA2 NF2 NOL12 OGDHL ORC3 OTX2 PDGFRA PGD PIAS1 PKM POLD1 PPP2R1B PRKAR1A PSMD10 PTMA QARS1 RAF1 RASSF1 RB1 RBL1 RBL2 RFC1 RFC4 RPL34 SENP3 SERTAD1 SETDB1 SHOX2 SKP1 SLBP SMAD2 SMAD3 SNCA SPOP STK11 STUB1 TEAD2 TERT TGFBR1 TK1 TP53 TRMT2A TSC1 TSPYL2 UBE3A UBTF UHRF2 USP17L2 USP51 VTA1 WDR33 YBX3 ZBTB16 ZNF101 ZNF219 ZNF335 ZNF655	55 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KCTD7 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLC22A1 SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM
Entrez ID		1019	823
HPRD ID		00447	00253
Ensembl ID		ENSG00000135446	ENSG00000014216
Uniprot IDs		P11802	B2RDI5 B4DWH5 P07384
PDB IDs		2W96 2W99 2W9F 2W9Z 3G33 5FWK 5FWL 5FWM 5FWP 6P8E 6P8F 6P8G 6P8H 7SJ3	1ZCM 2ARY 7W7O 7X79 8GX3
Enriched GO Terms of Interacting Partners?		Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of Cell Population Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Catalytic Activity Negative Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Kinase Activity Negative Regulation Of Apoptotic Process Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Phosphorylation Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Nucleoplasm Negative Regulation Of Cell Cycle Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of RNA Metabolic Process Negative Regulation Of Cell Population Proliferation Regulation Of Cell Cycle Process Cellular Response To Stress Protein Kinase Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process	Organelle Organization Regulation Of Programmed Cell Death Response To Alcohol Regulation Of Organelle Organization Regulation Of Apoptotic Process Identical Protein Binding Positive Regulation Of Organelle Organization Regulation Of Multicellular Organismal Process Protease Binding Cytoplasm Regulation Of Signal Transduction Regulation Of Cellular Component Organization Developmental Process Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Amino Acid Stimulus Positive Regulation Of Gene Expression Response To Lipid Positive Regulation Of Programmed Cell Death Negative Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Hepatocyte Apoptotic Process Cytosol Regulation Of Actin Filament Depolymerization Negative Regulation Of Apoptotic Process Cell Junction Maintenance Regulation Of Renin Secretion Into Blood Stream Regulation Of Autophagy Sarcomere Negative Regulation Of Programmed Cell Death Regulation Of Actin Filament-based Process Regulation Of Mitochondrial Membrane Permeability G-protein Beta-subunit Binding Regulation Of Protein Localization Response To Amino Acid Release Of Cytochrome C From Mitochondria Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Fluoride Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Apoptotic Process Cellular Component Maintenance Regulation Of Membrane Permeability Cysteine-type Peptidase Activity Positive Regulation Of Cellular Component Organization Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Protein Localization
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