CDK4 and IL15RA

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CDK4	IL15RA
Gene Name		cyclin-dependent kinase 4	interleukin 15 receptor, alpha
Image
Gene Ontology Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Tight Junction Nuclear Membrane Perinuclear Region Of Cytoplasm	Golgi Membrane Extracellular Space Endoplasmic Reticulum Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane Nuclear Membrane
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Cyclin Binding Protein Complex Binding	Signal Transducer Activity Cytokine Receptor Activity Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Lens Development In Camera-type Eye Chromatin Organization Protein Phosphorylation Signal Transduction Circadian Rhythm Positive Regulation Of Cell Proliferation Response To Toxic Substance Response To Lead Ion Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Organ Regeneration Response To Testosterone Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Translation Positive Regulation Of Cell Size Regulation Of Protein Kinase Activity Positive Regulation Of Fibroblast Proliferation Cell Division Response To Hyperoxia Negative Regulation Of Cell Cycle Arrest	Signal Transduction Cell Proliferation Cytokine-mediated Signaling Pathway
Pathways		Meiotic recombination Chromatin organization Ubiquitin-dependent degradation of Cyclin D Cellular Senescence G1 Phase Senescence-Associated Secretory Phenotype (SASP) S Phase Oncogene Induced Senescence Cell Cycle, Mitotic Ubiquitin-dependent degradation of Cyclin D1 RMTs methylate histone arginines Cyclin D associated events in G1 Chromatin modifying enzymes Oxidative Stress Induced Senescence Transcriptional regulation of white adipocyte differentiation Mitotic G1-G1/S phases
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 21383967)	Asthma (bronchodilator response) ( 23508266) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		90 interactors: ANKRD12 ANXA7 APLP1 APP ARID4A ATP5B BAG6 BCL11A BIRC5 BMPR1B BRCA1 CAMK1 CAPNS1 CCND1 CCND2 CCND3 CDC37 CDC45 CDC6 CDC7 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CDKN2D CEBPA CIB1 CNOT7 DAZAP2 DDAH2 DUSP9 FOXM1 GLI1 H1F0 HIST1H1A HIST1H1D HMGXB3 HOOK1 IFI27 IL15RA LUC7L2 MAPRE2 MARCKS MCM2 MYC MYOD1 MZF1 NCOA2 NOL12 ORC3 OTX2 PGD PKM POLD1 PPP2R1B PRKAR1A PSMD10 PTMA QARS RB1 RBL1 RBL2 RFC1 RFC4 RPL34 SENP3 SERTAD1 SETDB1 SHOX2 SKP1 SLBP SMAD2 SMAD3 SNCA TGFBR1 TK1 TRMT2A TSPYL2 UBTF UHRF2 VTA1 WDR33 ZBTB16 ZNF101 ZNF219 ZNF335 ZNF655 ZSCAN1	12 interactors: AXL BCL10 CASK CDK2 CDK4 IL15 IL2RB IL2RG PIAS4 RCVRN SYK TRAF2
Entrez ID		1019	3601
HPRD ID		00447	03045
Ensembl ID		ENSG00000135446	ENSG00000134470
Uniprot IDs		P11802 Q6LC83	G8CVM3 Q13261 Q3B769
PDB IDs		1LD2 2W96 2W99 2W9F 2W9Z 3G33	2ERS 2Z3Q 2Z3R 4GS7
Enriched GO Terms of Interacting Partners?		Cell Cycle Regulation Of Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Kinase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Gene Expression Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Gene Expression Regulation Of Cell Proliferation Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cell Cycle RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Phosphorylation Gene Expression Negative Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Phosphorylation Chromosome Organization Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Regulation Of RNA Biosynthetic Process	Positive Regulation Of Cell Activation Positive Regulation Of Cellular Metabolic Process Signal Transduction Regulation Of Lymphocyte Activation Positive Regulation Of Intracellular Signal Transduction Interleukin-2-mediated Signaling Pathway Signaling Cell Communication Regulation Of Cell Activation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Metabolic Process Regulation Of Cytokine Production Positive Regulation Of Cell-cell Adhesion Response To Organic Substance Cellular Response To Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Adhesion Regulation Of T Cell Activation Cellular Response To Nitric Oxide Response To Interleukin-2 Positive Regulation Of Protein Metabolic Process Positive Regulation Of Lymphocyte Differentiation Regulation Of Cellular Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Reactive Oxygen Species Positive Regulation Of Signal Transduction Positive Regulation Of Natural Killer Cell Differentiation Immune Response Response To Nitric Oxide Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Natural Killer Cell Differentiation Regulation Of Cell Death Positive Regulation Of Immune System Process Cellular Response To Reactive Nitrogen Species Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Lymphocyte Differentiation Response To Inorganic Substance Response To Stimulus Positive Regulation Of Natural Killer Cell Activation Regulation Of Intracellular Signal Transduction Positive Regulation Of Tissue Remodeling Response To Reactive Oxygen Species
Tagcloud ?		aberrantly acetylglucosaminyltransferase antigens bage ctl ecto fig fm3 fm57 gage gp100 immunogenic immunogenicity in4 maa mage mart melan melanocyte melanomas p15 pbl permitted pointing prame ref tab trp tyrosinase uncloned	acidophilus ccl22 ccl3 ccl4 cd5 cd80 cd86 cocultivation crlf2 csf2ra cxcl11 dqa1 hivep2 icam1 ido1 il1a il1b il23a il2ra il6 il7r il8 lactobacillus nfkb1 nfkb2 probiotic relb thp tlr7
Tagcloud (Difference) ?		aberrantly acetylglucosaminyltransferase antigens bage ctl ecto fig fm3 fm57 gage gp100 immunogenic immunogenicity in4 maa mage mart melan melanocyte melanomas p15 pbl permitted pointing prame ref tab trp tyrosinase uncloned	acidophilus ccl22 ccl3 ccl4 cd5 cd80 cd86 cocultivation crlf2 csf2ra cxcl11 dqa1 hivep2 icam1 ido1 il1a il1b il23a il2ra il6 il7r il8 lactobacillus nfkb1 nfkb2 probiotic relb thp tlr7
Tagcloud (Intersection) ?