CDK4 and PGD

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CDK4	PGD
Gene Name		cyclin-dependent kinase 4	phosphogluconate dehydrogenase
Image
Gene Ontology Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Tight Junction Nuclear Membrane Perinuclear Region Of Cytoplasm	Nucleus Cytosol Extracellular Vesicular Exosome
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Cyclin Binding Protein Complex Binding	Phosphogluconate Dehydrogenase (decarboxylating) Activity NADP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Lens Development In Camera-type Eye Chromatin Organization Protein Phosphorylation Signal Transduction Circadian Rhythm Positive Regulation Of Cell Proliferation Response To Toxic Substance Response To Lead Ion Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Organ Regeneration Response To Testosterone Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Translation Positive Regulation Of Cell Size Regulation Of Protein Kinase Activity Positive Regulation Of Fibroblast Proliferation Cell Division Response To Hyperoxia Negative Regulation Of Cell Cycle Arrest	Carbohydrate Metabolic Process Pentose-phosphate Shunt Pentose-phosphate Shunt, Oxidative Branch Pathogenesis Pentose Biosynthetic Process D-gluconate Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Meiotic recombination Chromatin organization Ubiquitin-dependent degradation of Cyclin D Cellular Senescence G1 Phase Senescence-Associated Secretory Phenotype (SASP) S Phase Oncogene Induced Senescence Cell Cycle, Mitotic Ubiquitin-dependent degradation of Cyclin D1 RMTs methylate histone arginines Cyclin D associated events in G1 Chromatin modifying enzymes Oxidative Stress Induced Senescence Transcriptional regulation of white adipocyte differentiation Mitotic G1-G1/S phases	Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates Pentose phosphate pathway (hexose monophosphate shunt)
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 21383967)	Hepatocellular carcinoma ( 20676096)
Protein-Protein Interactions		90 interactors: ANKRD12 ANXA7 APLP1 APP ARID4A ATP5B BAG6 BCL11A BIRC5 BMPR1B BRCA1 CAMK1 CAPNS1 CCND1 CCND2 CCND3 CDC37 CDC45 CDC6 CDC7 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CDKN2D CEBPA CIB1 CNOT7 DAZAP2 DDAH2 DUSP9 FOXM1 GLI1 H1F0 HIST1H1A HIST1H1D HMGXB3 HOOK1 IFI27 IL15RA LUC7L2 MAPRE2 MARCKS MCM2 MYC MYOD1 MZF1 NCOA2 NOL12 ORC3 OTX2 PGD PKM POLD1 PPP2R1B PRKAR1A PSMD10 PTMA QARS RB1 RBL1 RBL2 RFC1 RFC4 RPL34 SENP3 SERTAD1 SETDB1 SHOX2 SKP1 SLBP SMAD2 SMAD3 SNCA TGFBR1 TK1 TRMT2A TSPYL2 UBTF UHRF2 VTA1 WDR33 ZBTB16 ZNF101 ZNF219 ZNF335 ZNF655 ZSCAN1	4 interactors: CDK4 GBE1 LSM8 TERF1
Entrez ID		1019	5226
HPRD ID		00447	01391
Ensembl ID		ENSG00000135446	ENSG00000142657
Uniprot IDs		P11802 Q6LC83	P52209
PDB IDs		1LD2 2W96 2W99 2W9F 2W9Z 3G33	2JKV 4GWG 4GWK
Enriched GO Terms of Interacting Partners?		Cell Cycle Regulation Of Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Kinase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Gene Expression Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Gene Expression Regulation Of Cell Proliferation Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cell Cycle RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Phosphorylation Gene Expression Negative Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Phosphorylation Chromosome Organization Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Regulation Of RNA Biosynthetic Process	Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Telomere Maintenance Via Telomere Shortening Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Negative Regulation Of Telomere Maintenance Via Telomerase Replicative Cell Aging Negative Regulation Of Telomerase Activity Positive Regulation Of Cell Size Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Mitotic Cell Cycle Regulation Of Telomere Maintenance Via Telomerase Cell Division Negative Regulation Of Cell Cycle Positive Regulation Of Microtubule Polymerization Regulation Of Cell Cycle Process Regulation Of Telomerase Activity Response To Drug Regulation Of Telomere Maintenance Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death RNA-dependent DNA Replication Positive Regulation Of Cell Death Negative Regulation Of Cell Cycle Arrest Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Lead Ion Glycogen Biosynthetic Process Response To Hyperoxia Mitotic Cell Cycle Process Regulation Of Microtubule Polymerization Chromatin Organization Telomere Maintenance Via Telomere Lengthening Response To Testosterone Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Cellular Polysaccharide Biosynthetic Process Mitotic Spindle Checkpoint Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Chromosome Segregation Polysaccharide Biosynthetic Process
Tagcloud ?		aberrantly acetylglucosaminyltransferase antigens bage ctl ecto fig fm3 fm57 gage gp100 immunogenic immunogenicity in4 maa mage mart melan melanocyte melanomas p15 pbl permitted pointing prame ref tab trp tyrosinase uncloned	a2 achieved actions advances bk1 bk2 bk3 bk4 bradykinin characterization detail diverse ep1 ep2 ep3 ep4 exert hypertension pge prostacyclin prostaglandin prostanoid prostanoids remarkable reviewed subtypes thromboxane versatile
Tagcloud (Difference) ?		aberrantly acetylglucosaminyltransferase antigens bage ctl ecto fig fm3 fm57 gage gp100 immunogenic immunogenicity in4 maa mage mart melan melanocyte melanomas p15 pbl permitted pointing prame ref tab trp tyrosinase uncloned	a2 achieved actions advances bk1 bk2 bk3 bk4 bradykinin characterization detail diverse ep1 ep2 ep3 ep4 exert hypertension pge prostacyclin prostaglandin prostanoid prostanoids remarkable reviewed subtypes thromboxane versatile
Tagcloud (Intersection) ?