Wiki-Pi
About
Search
People
Updates
Search
CDK4 and UBTF
Number of citations of the paper that reports this interaction (PubMedID
10202152
)
31
Data Source:
BioGRID
(enzymatic study)
CDK4
UBTF
Description
cyclin dependent kinase 4
upstream binding transcription factor
Image
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytoplasm
Cytosol
Bicellular Tight Junction
Membrane
Nuclear Membrane
Cyclin D1-CDK4 Complex
Cyclin D2-CDK4 Complex
Cyclin D3-CDK4 Complex
Fibrillar Center
Nucleus
Nucleoplasm
Nucleolus
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Transferase Activity
Cyclin Binding
Protein Serine Kinase Activity
RNA Polymerase I Core Promoter Sequence-specific DNA Binding
RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase I General Transcription Initiation Factor Activity
DNA Binding
Chromatin Binding
RNA Binding
Protein Binding
Scaffold Protein Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Fibroblast Proliferation
Cell Division
Regulation Of Cell Cycle
Regulation Of Transcription Initiation By RNA Polymerase II
Regulation Of Type B Pancreatic Cell Proliferation
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-4
Cellular Response To Phorbol 13-acetate 12-myristate
Cellular Response To Ionomycin
RNA Polymerase I Preinitiation Complex Assembly
Transcription By RNA Polymerase I
Transcription Initiation At RNA Polymerase I Promoter
Positive Regulation Of Transcription By RNA Polymerase I
Regulation Of Glucose Mediated Signaling Pathway
Pathways
SCF(Skp2)-mediated degradation of p27/p21
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
RMTs methylate histone arginines
Transcriptional regulation of white adipocyte differentiation
Cyclin D associated events in G1
Ubiquitin-dependent degradation of Cyclin D
Ubiquitin-dependent degradation of Cyclin D
PTK6 Regulates Cell Cycle
Transcriptional regulation by RUNX2
Meiotic recombination
Transcriptional regulation of granulopoiesis
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drug-mediated inhibition of CDK4/CDK6 activity
SPOP-mediated proteasomal degradation of PD-L1(CD274)
NoRC negatively regulates rRNA expression
RNA Polymerase I Promoter Opening
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase I Transcription Termination
Drugs
Purvalanol
Alvocidib
Palbociclib
Ribociclib
Abemaciclib
Fostamatinib
Trilaciclib
Diseases
Malignant melanoma
Glioma
Cervical cancer
GWAS
Brain morphology (MOSTest) (
32665545
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Rheumatoid arthritis (
24390342
30423114
)
Bipolar disorder (
31043756
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Diverticular disease (
30177863
)
hemolysis of donated blood (osmotic) (
34014839
)
Mean corpuscular hemoglobin concentration (
29403010
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Interacting Genes
136 interacting genes:
AGAP2
AKT1
ANKRD12
ANXA7
APLP1
APP
ARAF
ARID4A
ARNT
ATP5F1B
BAG6
BCL11A
BECN1
BIRC5
BMPR1B
BRCA1
CAMK1
CAPNS1
CCND1
CCND2
CCND3
CCNE1
CD44
CDC37
CDC45
CDC6
CDC7
CDKN1A
CDKN1B
CDKN1C
CDKN2A
CDKN2B
CDKN2C
CDKN2D
CEBPA
CIB1
CNOT7
CNTN2
DAZAP2
DDAH2
DUSP9
EIF4EBP2
EPHA2
ERBB2
FARP2
FBXO8
FGFR4
FOXM1
FZR1
GLIS2
GRM1
H1-0
H1-1
H1-3
HGF
HIF1A
HMGXB3
HOOK1
HSP90AB1
IFI27
IGF1R
IKZF3
IL15RA
INCA1
KDELR2
LATS2
LNX2
LUC7L2
MAP2K3
MAP2K5
MAP3K5
MAPK14
MAPRE2
MARCKS
MCM2
MDM4
MET
MYOD1
MZF1
NCOA2
NF2
NOL12
OGDHL
ORC3
OTX2
PDGFRA
PGD
PIAS1
PKM
POLD1
PPP2R1B
PRKAR1A
PSMD10
PTMA
QARS1
RAF1
RASSF1
RB1
RBL1
RBL2
RFC1
RFC4
RPL34
SENP3
SERTAD1
SETDB1
SHOX2
SKP1
SLBP
SMAD2
SMAD3
SNCA
SPOP
STK11
STUB1
TEAD2
TERT
TGFBR1
TK1
TP53
TRMT2A
TSC1
TSPYL2
UBE3A
UBTF
UHRF2
USP17L2
USP51
VTA1
WDR33
YBX3
ZBTB16
ZNF101
ZNF219
ZNF335
ZNF655
37 interacting genes:
AURKA
CCNA2
CCND1
CCNE1
CDK2
CDK4
CEBPA
CENPC
CHGB
CREBBP
CSNK2A1
EP300
GSK3A
IRS1
IRS2
LEF1
MAD1L1
MAPK1
MAPK3
MDM2
POLR1E
POLR1G
RB1
RBL2
RNF10
RUNX2
SERPINH1
SMURF1
TAF1
TAF1A
TAF1B
TAF1C
TAF1D
TBP
TCOF1
USP7
ZMYM2
Entrez ID
1019
7343
HPRD ID
00447
02814
Ensembl ID
ENSG00000135446
ENSG00000108312
Uniprot IDs
P11802
P17480
PDB IDs
2W96
2W99
2W9F
2W9Z
3G33
5FWK
5FWL
5FWM
5FWP
6P8E
6P8F
6P8G
6P8H
7SJ3
1K99
1L8Y
1L8Z
2HDZ
Enriched GO Terms of Interacting Partners
?
Regulation Of Primary Metabolic Process
Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Nucleus
Regulation Of Cell Population Proliferation
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Cycle
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Regulation Of Catalytic Activity
Negative Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Signal Transduction
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Modification Process
Regulation Of Phosphorus Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Kinase Activity
Negative Regulation Of Apoptotic Process
Intracellular Signal Transduction
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Phosphorylation
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Nucleoplasm
Negative Regulation Of Cell Cycle
Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Mitotic Cell Cycle
Regulation Of Protein Kinase Activity
Regulation Of Protein Phosphorylation
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Cycle Process
Cellular Response To Stress
Protein Kinase Binding
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Transcription By RNA Polymerase I
DNA-templated Transcription
RNA Polymerase Transcription Factor SL1 Complex
Nucleoplasm
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Nucleus
Transcription Regulator Complex
Nucleobase-containing Compound Biosynthetic Process
Regulation Of Proteasomal Protein Catabolic Process
Transcription Initiation At RNA Polymerase I Promoter
Regulation Of Cell Cycle Phase Transition
Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Regulation Of RNA Biosynthetic Process
Nucleic Acid Metabolic Process
RNA Polymerase I Preinitiation Complex Assembly
Regulation Of Proteolysis
RNA Metabolic Process
RNA Polymerase I Transcription Regulator Complex
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Cell Population Proliferation
Macromolecule Biosynthetic Process
Positive Regulation Of Catabolic Process
Regulation Of Macromolecule Biosynthetic Process
Macromolecule Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Regulation Of Cell Cycle Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Cell Population Proliferation
Cell Division
Mitotic Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle Phase Transition
Nucleobase-containing Compound Metabolic Process
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleolar Large RRNA Transcription By RNA Polymerase I
Cell Cycle Phase Transition
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Process
Regulation Of Protein Catabolic Process
Regulation Of Protein Stability
Gland Development
DNA-binding Transcription Factor Binding
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Cycle
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?