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CDK4 and UBTF
Number of citations of the paper that reports this interaction (PMID
10202152
)
43
Data Source:
BioGRID
(enzymatic study)
CDK4
UBTF
Gene Name
cyclin-dependent kinase 4
upstream binding transcription factor, RNA polymerase I
Image
Gene Ontology Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Factor Complex
Nucleolus
Cytosol
Tight Junction
Nuclear Membrane
Perinuclear Region Of Cytoplasm
Nucleoplasm
Nucleolus
Molecular Function
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Cyclin Binding
Protein Complex Binding
DNA Binding
Chromatin Binding
Protein Binding
Poly(A) RNA Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Lens Development In Camera-type Eye
Chromatin Organization
Protein Phosphorylation
Signal Transduction
Circadian Rhythm
Positive Regulation Of Cell Proliferation
Response To Toxic Substance
Response To Lead Ion
Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Organ Regeneration
Response To Testosterone
Response To Drug
Positive Regulation Of Apoptotic Process
Positive Regulation Of Translation
Positive Regulation Of Cell Size
Regulation Of Protein Kinase Activity
Positive Regulation Of Fibroblast Proliferation
Cell Division
Response To Hyperoxia
Negative Regulation Of Cell Cycle Arrest
Chromatin Remodeling
Regulation Of Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase I Promoter
Transcription From RNA Polymerase I Promoter
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Gene Expression
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription From RNA Polymerase I Promoter
Pathways
Meiotic recombination
Chromatin organization
Ubiquitin-dependent degradation of Cyclin D
Cellular Senescence
G1 Phase
Senescence-Associated Secretory Phenotype (SASP)
S Phase
Oncogene Induced Senescence
Cell Cycle, Mitotic
Ubiquitin-dependent degradation of Cyclin D1
RMTs methylate histone arginines
Cyclin D associated events in G1
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
Transcriptional regulation of white adipocyte differentiation
Mitotic G1-G1/S phases
NoRC negatively regulates rRNA expression
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription
RNA Polymerase I Promoter Escape
RNA Polymerase I Transcription Termination
RNA Polymerase I Promoter Clearance
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
RNA Polymerase I Promoter Opening
Drugs
Diseases
GWAS
Celiac disease and Rheumatoid arthritis (
21383967
)
Protein-Protein Interactions
90 interactors:
ANKRD12
ANXA7
APLP1
APP
ARID4A
ATP5B
BAG6
BCL11A
BIRC5
BMPR1B
BRCA1
CAMK1
CAPNS1
CCND1
CCND2
CCND3
CDC37
CDC45
CDC6
CDC7
CDKN1A
CDKN1B
CDKN1C
CDKN2A
CDKN2B
CDKN2C
CDKN2D
CEBPA
CIB1
CNOT7
DAZAP2
DDAH2
DUSP9
FOXM1
GLI1
H1F0
HIST1H1A
HIST1H1D
HMGXB3
HOOK1
IFI27
IL15RA
LUC7L2
MAPRE2
MARCKS
MCM2
MYC
MYOD1
MZF1
NCOA2
NOL12
ORC3
OTX2
PGD
PKM
POLD1
PPP2R1B
PRKAR1A
PSMD10
PTMA
QARS
RB1
RBL1
RBL2
RFC1
RFC4
RPL34
SENP3
SERTAD1
SETDB1
SHOX2
SKP1
SLBP
SMAD2
SMAD3
SNCA
TGFBR1
TK1
TRMT2A
TSPYL2
UBTF
UHRF2
VTA1
WDR33
ZBTB16
ZNF101
ZNF219
ZNF335
ZNF655
ZSCAN1
31 interactors:
CCNA2
CCND1
CCNE1
CD3EAP
CDK2
CDK4
CENPC
CHGB
CREBBP
CSNK2A1
IRS1
IRS2
LEF1
MAD1L1
MAPK1
MAPK3
MDM2
POLR1E
RB1
RBL2
RUNX2
SERPINH1
SMURF1
TAF1
TAF1A
TAF1B
TAF1C
TAF1D
TBP
TCOF1
ZMYM2
Entrez ID
1019
7343
HPRD ID
00447
02814
Ensembl ID
ENSG00000135446
ENSG00000108312
Uniprot IDs
P11802
Q6LC83
P17480
PDB IDs
1LD2
2W96
2W99
2W9F
2W9Z
3G33
1K99
1L8Y
1L8Z
2HDZ
Enriched GO Terms of Interacting Partners
?
Cell Cycle
Regulation Of Cell Cycle
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Cell Cycle Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Kinase Activity
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Negative Regulation Of Gene Expression
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Mitotic Cell Cycle
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Regulation Of Phosphorylation
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Protein Kinase Activity
Negative Regulation Of Biosynthetic Process
Regulation Of Cellular Protein Metabolic Process
Cellular Metabolic Process
Regulation Of Phosphorus Metabolic Process
Regulation Of Gene Expression
Regulation Of Cell Proliferation
Biosynthetic Process
Regulation Of Protein Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Regulation Of Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Cell Cycle
RNA Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Protein Phosphorylation
Gene Expression
Negative Regulation Of Cell Cycle
Positive Regulation Of Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Transcription, DNA-templated
Negative Regulation Of Phosphorylation
Chromosome Organization
Regulation Of Nucleic Acid-templated Transcription
Transcription, DNA-templated
Regulation Of RNA Biosynthetic Process
Transcription From RNA Polymerase I Promoter
Transcription Initiation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription Elongation From RNA Polymerase I Promoter
DNA-templated Transcription, Initiation
DNA-templated Transcription, Elongation
Regulation Of Gene Expression
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Metabolic Process
Macromolecule Biosynthetic Process
DNA-templated Transcription, Termination
Negative Regulation Of Gene Expression, Epigenetic
Chromatin Silencing At RDNA
Cellular Macromolecule Biosynthetic Process
Gene Expression
Regulation Of Mitotic Cell Cycle Phase Transition
Cell Cycle
Regulation Of Cell Cycle Phase Transition
RNA Metabolic Process
Regulation Of Transcription, DNA-templated
Biosynthetic Process
Regulation Of Nucleic Acid-templated Transcription
Chromatin Silencing
Regulation Of RNA Biosynthetic Process
Mitotic Cell Cycle
Positive Regulation Of Macromolecule Biosynthetic Process
Mitotic Cell Cycle Checkpoint
Regulation Of RNA Metabolic Process
Cell Division
Positive Regulation Of Cellular Biosynthetic Process
Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter
Negative Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Cell Proliferation
Regulation Of Cell Cycle Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Mitotic Cell Cycle Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Cell Cycle
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Cell Cycle Checkpoint
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Gene Expression
JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
RRNA Transcription
Tagcloud
?
aberrantly
acetylglucosaminyltransferase
antigens
bage
ctl
ecto
fig
fm3
fm57
gage
gp100
immunogenic
immunogenicity
in4
maa
mage
mart
melan
melanocyte
melanomas
p15
pbl
permitted
pointing
prame
ref
tab
trp
tyrosinase
uncloned
Tagcloud (Difference)
?
aberrantly
acetylglucosaminyltransferase
antigens
bage
ctl
ecto
fig
fm3
fm57
gage
gp100
immunogenic
immunogenicity
in4
maa
mage
mart
melan
melanocyte
melanomas
p15
pbl
permitted
pointing
prame
ref
tab
trp
tyrosinase
uncloned
Tagcloud (Intersection)
?