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CDK4 and CDKN2C
Number of citations of the paper that reports this interaction (PubMedID
8001816
)
0
Data Source:
HPRD
(in vitro, in vivo)
CDK4
CDKN2C
Description
cyclin dependent kinase 4
cyclin dependent kinase inhibitor 2C
Image
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytoplasm
Cytosol
Bicellular Tight Junction
Membrane
Nuclear Membrane
Cyclin D1-CDK4 Complex
Cyclin D2-CDK4 Complex
Cyclin D3-CDK4 Complex
Nucleus
Cytoplasm
Cytosol
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Transferase Activity
Cyclin Binding
Protein Serine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Protein Kinase Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Fibroblast Proliferation
Cell Division
Regulation Of Cell Cycle
Regulation Of Transcription Initiation By RNA Polymerase II
Regulation Of Type B Pancreatic Cell Proliferation
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-4
Cellular Response To Phorbol 13-acetate 12-myristate
Cellular Response To Ionomycin
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Growth
Oligodendrocyte Differentiation
Stem Cell Proliferation
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Stem Cell Proliferation
Pathways
SCF(Skp2)-mediated degradation of p27/p21
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
RMTs methylate histone arginines
Transcriptional regulation of white adipocyte differentiation
Cyclin D associated events in G1
Ubiquitin-dependent degradation of Cyclin D
Ubiquitin-dependent degradation of Cyclin D
PTK6 Regulates Cell Cycle
Transcriptional regulation by RUNX2
Meiotic recombination
Transcriptional regulation of granulopoiesis
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drug-mediated inhibition of CDK4/CDK6 activity
SPOP-mediated proteasomal degradation of PD-L1(CD274)
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Cyclin D associated events in G1
Drugs
Purvalanol
Alvocidib
Palbociclib
Ribociclib
Abemaciclib
Fostamatinib
Trilaciclib
Diseases
Malignant melanoma
Glioma
Cervical cancer
GWAS
Brain morphology (MOSTest) (
32665545
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Rheumatoid arthritis (
24390342
30423114
)
Atrial fibrillation (
29290336
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cataracts (
34127677
)
Cataracts (operation) (
31816047
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Height (
33713608
31562340
)
Hip circumference adjusted for BMI (
34021172
)
Hippocampal tail volume (corrected for total hippocampal volume) (
30279459
)
Ischemic stroke (large artery atherosclerosis) (
26732560
)
Male-pattern baldness (
28196072
)
Pulse pressure (
30578418
)
QRS complex (12-leadsum) (
27659466
)
QRS duration (
27577874
21076409
27659466
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Thyroid stimulating hormone levels (
32769997
)
Ventricular ectopy (
29618737
)
Ventricular ectopy or supraventricular ectopy (pleiotropy) (
29618737
)
Interacting Genes
136 interacting genes:
AGAP2
AKT1
ANKRD12
ANXA7
APLP1
APP
ARAF
ARID4A
ARNT
ATP5F1B
BAG6
BCL11A
BECN1
BIRC5
BMPR1B
BRCA1
CAMK1
CAPNS1
CCND1
CCND2
CCND3
CCNE1
CD44
CDC37
CDC45
CDC6
CDC7
CDKN1A
CDKN1B
CDKN1C
CDKN2A
CDKN2B
CDKN2C
CDKN2D
CEBPA
CIB1
CNOT7
CNTN2
DAZAP2
DDAH2
DUSP9
EIF4EBP2
EPHA2
ERBB2
FARP2
FBXO8
FGFR4
FOXM1
FZR1
GLIS2
GRM1
H1-0
H1-1
H1-3
HGF
HIF1A
HMGXB3
HOOK1
HSP90AB1
IFI27
IGF1R
IKZF3
IL15RA
INCA1
KDELR2
LATS2
LNX2
LUC7L2
MAP2K3
MAP2K5
MAP3K5
MAPK14
MAPRE2
MARCKS
MCM2
MDM4
MET
MYOD1
MZF1
NCOA2
NF2
NOL12
OGDHL
ORC3
OTX2
PDGFRA
PGD
PIAS1
PKM
POLD1
PPP2R1B
PRKAR1A
PSMD10
PTMA
QARS1
RAF1
RASSF1
RB1
RBL1
RBL2
RFC1
RFC4
RPL34
SENP3
SERTAD1
SETDB1
SHOX2
SKP1
SLBP
SMAD2
SMAD3
SNCA
SPOP
STK11
STUB1
TEAD2
TERT
TGFBR1
TK1
TP53
TRMT2A
TSC1
TSPYL2
UBE3A
UBTF
UHRF2
USP17L2
USP51
VTA1
WDR33
YBX3
ZBTB16
ZNF101
ZNF219
ZNF335
ZNF655
59 interacting genes:
AHCYL1
AKT1
ANGPTL4
APLP1
ARNT
ATM
ATR
CCDC90B
CCND2
CCNE1
CDK4
CDK6
CDKN2A
CDKN2B
COPS6
CRX
CTDSP1
DRAP1
EPHA2
ERBB2
FGFR4
GDF9
GOPC
GREB1
GRM1
KRT31
LATS2
LNX2
LRIF1
LY96
MAP2K3
MAP2K5
MAPK10
MAPK8
MTA3
MYC
NAGK
NAT2
NF2
NIF3L1
PBX4
PDGFRA
PLEKHG4
POU6F2
PPP2CA
RAF1
RBM48
REL
SCGB2A2
SNU13
SORBS3
ST14
STK11
TCF12
TCF4
TLE1
TP53
UBC
UNC119
Entrez ID
1019
1031
HPRD ID
00447
04534
Ensembl ID
ENSG00000135446
ENSG00000123080
Uniprot IDs
P11802
P42773
Q6ICV4
PDB IDs
2W96
2W99
2W9F
2W9Z
3G33
5FWK
5FWL
5FWM
5FWP
6P8E
6P8F
6P8G
6P8H
7SJ3
1BU9
1G3N
1IHB
1MX2
1MX4
1MX6
Enriched GO Terms of Interacting Partners
?
Regulation Of Primary Metabolic Process
Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Nucleus
Regulation Of Cell Population Proliferation
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Cycle
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Regulation Of Catalytic Activity
Negative Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Signal Transduction
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Modification Process
Regulation Of Phosphorus Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Kinase Activity
Negative Regulation Of Apoptotic Process
Intracellular Signal Transduction
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Phosphorylation
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Nucleoplasm
Negative Regulation Of Cell Cycle
Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Mitotic Cell Cycle
Regulation Of Protein Kinase Activity
Regulation Of Protein Phosphorylation
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Cycle Process
Cellular Response To Stress
Protein Kinase Binding
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Kinase Activity
Protein Kinase Activity
Regulation Of Mitotic Cell Cycle Phase Transition
Protein Serine Kinase Activity
Regulation Of Cell Cycle Phase Transition
Cellular Senescence
Phosphorylation
Protein Serine/threonine Kinase Activity
Regulation Of Mitotic Cell Cycle
Protein Phosphorylation
Intracellular Signal Transduction
Mitotic Cell Cycle Phase Transition
Regulation Of Primary Metabolic Process
Regulation Of Epithelial Cell Proliferation
Regulation Of Cell Cycle
Regulation Of Intracellular Signal Transduction
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Cell Cycle Phase Transition
Signal Transduction
MAPK Cascade
Regulation Of Cell Cycle Process
Replicative Senescence
Positive Regulation Of Signal Transduction
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Macromolecule Metabolic Process
Response To Radiation
Regulation Of Cell Population Proliferation
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Regulation Of RNA Metabolic Process
Regulation Of Signal Transduction
Intracellular Signaling Cassette
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Metabolic Process
Positive Regulation Of Cell Communication
Response To UV
Positive Regulation Of Signaling
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Response To Light Stimulus
Cellular Response To Radiation
Regulation Of Signaling
Regulation Of Cell Communication
ATP Binding
Regulation Of Catalytic Activity
Regulation Of Transcription By RNA Polymerase II
Regulation Of Phosphorus Metabolic Process
Regulation Of Cell Cycle G2/M Phase Transition
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Tagcloud (Difference)
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Tagcloud (Intersection)
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