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CDK4 and TGFBR1
Number of citations of the paper that reports this interaction (PubMedID
15761153
)
0
Data Source:
HPRD
(in vivo)
CDK4
TGFBR1
Description
cyclin dependent kinase 4
transforming growth factor beta receptor 1
Image
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytoplasm
Cytosol
Bicellular Tight Junction
Membrane
Nuclear Membrane
Cyclin D1-CDK4 Complex
Cyclin D2-CDK4 Complex
Cyclin D3-CDK4 Complex
Nucleus
Nucleoplasm
Endosome
Plasma Membrane
Bicellular Tight Junction
Cilium
Cell Surface
Membrane
Receptor Complex
Membrane Raft
Activin Receptor Complex
Transforming Growth Factor Beta Ligand-receptor Complex
Anchoring Junction
Serine/threonine Protein Kinase Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Transferase Activity
Cyclin Binding
Protein Serine Kinase Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Activity
Transforming Growth Factor Beta Receptor Activity, Type I
Signaling Receptor Binding
Type II Transforming Growth Factor Beta Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Activin Receptor Activity, Type I
Transferase Activity
Growth Factor Binding
Ubiquitin Protein Ligase Binding
SMAD Binding
Metal Ion Binding
Activin Binding
Transforming Growth Factor Beta Binding
I-SMAD Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Fibroblast Proliferation
Cell Division
Regulation Of Cell Cycle
Regulation Of Transcription Initiation By RNA Polymerase II
Regulation Of Type B Pancreatic Cell Proliferation
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-4
Cellular Response To Phorbol 13-acetate 12-myristate
Cellular Response To Ionomycin
Skeletal System Development
Angiogenesis
In Utero Embryonic Development
Kidney Development
Blastocyst Development
Epithelial To Mesenchymal Transition
Endothelial Cell Proliferation
Negative Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Lens Development In Camera-type Eye
Ventricular Trabecula Myocardium Morphogenesis
Ventricular Compact Myocardium Morphogenesis
Proepicardium Development
Regulation Of DNA-templated Transcription
Apoptotic Process
Signal Transduction
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Nervous System Development
Heart Development
Positive Regulation Of Cell Population Proliferation
Germ Cell Migration
Male Gonad Development
Post-embryonic Development
Anterior/posterior Pattern Specification
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Epithelial To Mesenchymal Transition
Peptidyl-serine Phosphorylation
Cell Differentiation
Collagen Fibril Organization
Positive Regulation Of Cell Growth
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Negative Regulation Of Cell Migration
Regulation Of Protein Ubiquitination
Negative Regulation Of Chondrocyte Differentiation
Activin Receptor Signaling Pathway
Intracellular Signal Transduction
Myofibroblast Differentiation
Wound Healing
Endothelial Cell Activation
Extracellular Structure Organization
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Endothelial Cell Migration
Positive Regulation Of DNA-templated Transcription
Filopodium Assembly
Thymus Development
Neuron Fate Commitment
Embryonic Cranial Skeleton Morphogenesis
Skeletal System Morphogenesis
Mesenchymal Cell Differentiation
Artery Morphogenesis
Cell Motility
Positive Regulation Of Filopodium Assembly
Positive Regulation Of Stress Fiber Assembly
Regulation Of Cell Cycle
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Parathyroid Gland Development
Roof Of Mouth Development
Pharyngeal System Development
Regulation Of Cardiac Muscle Cell Proliferation
Cardiac Epithelial To Mesenchymal Transition
Positive Regulation Of SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Angiogenesis Involved In Coronary Vascular Morphogenesis
Coronary Artery Morphogenesis
Trophoblast Cell Migration
Response To Cholesterol
Cellular Response To Growth Factor Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Alcohol
Vascular Endothelial Cell Proliferation
Positive Regulation Of Extracellular Matrix Assembly
Positive Regulation Of Mesenchymal Stem Cell Proliferation
Positive Regulation Of Vasculature Development
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Positive Regulation Of Tight Junction Disassembly
Epicardium Morphogenesis
Regulation Of Multicellular Organismal Development
Positive Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
SCF(Skp2)-mediated degradation of p27/p21
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
RMTs methylate histone arginines
Transcriptional regulation of white adipocyte differentiation
Cyclin D associated events in G1
Ubiquitin-dependent degradation of Cyclin D
Ubiquitin-dependent degradation of Cyclin D
PTK6 Regulates Cell Cycle
Transcriptional regulation by RUNX2
Meiotic recombination
Transcriptional regulation of granulopoiesis
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drug-mediated inhibition of CDK4/CDK6 activity
SPOP-mediated proteasomal degradation of PD-L1(CD274)
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
UCH proteinases
Ub-specific processing proteases
TGFBR3 regulates TGF-beta signaling
Drugs
Purvalanol
Alvocidib
Palbociclib
Ribociclib
Abemaciclib
Fostamatinib
Trilaciclib
4-(3-Pyridin-2-Yl-1h-Pyrazol-4-Yl)Quinoline
Naphthyridine Inhibitor
3-(4-Fluorophenyl)-2-(6-Methylpyridin-2-Yl)-5,6-Dihydro-4h-Pyrrolo[1,2-B]Pyrazole
N-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]acetamide
2-(6-methylpyridin-2-yl)-N-pyridin-4-ylquinazolin-4-amine
N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine
Fostamatinib
Diseases
Malignant melanoma
Glioma
Cervical cancer
Loeys-Dietz syndrome (LDS)
Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS
Brain morphology (MOSTest) (
32665545
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Rheumatoid arthritis (
24390342
30423114
)
Advanced age-related macular degeneration (
26691988
)
Age-related macular degeneration (
23455636
)
Asthma (
31959851
32296059
34103634
)
Callous-unemotional behaviour (
23874384
)
Cough in response to angiotensin-converting enzyme inhibitor drugs (
28084903
)
Dental caries (
23064961
)
Epithelial ovarian cancer (
25134534
)
Fractures (paediatric) (
32742401
)
Gestational age at birth (maternal effect) (
28877031
)
Refractive error (
32231278
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Interacting Genes
136 interacting genes:
AGAP2
AKT1
ANKRD12
ANXA7
APLP1
APP
ARAF
ARID4A
ARNT
ATP5F1B
BAG6
BCL11A
BECN1
BIRC5
BMPR1B
BRCA1
CAMK1
CAPNS1
CCND1
CCND2
CCND3
CCNE1
CD44
CDC37
CDC45
CDC6
CDC7
CDKN1A
CDKN1B
CDKN1C
CDKN2A
CDKN2B
CDKN2C
CDKN2D
CEBPA
CIB1
CNOT7
CNTN2
DAZAP2
DDAH2
DUSP9
EIF4EBP2
EPHA2
ERBB2
FARP2
FBXO8
FGFR4
FOXM1
FZR1
GLIS2
GRM1
H1-0
H1-1
H1-3
HGF
HIF1A
HMGXB3
HOOK1
HSP90AB1
IFI27
IGF1R
IKZF3
IL15RA
INCA1
KDELR2
LATS2
LNX2
LUC7L2
MAP2K3
MAP2K5
MAP3K5
MAPK14
MAPRE2
MARCKS
MCM2
MDM4
MET
MYOD1
MZF1
NCOA2
NF2
NOL12
OGDHL
ORC3
OTX2
PDGFRA
PGD
PIAS1
PKM
POLD1
PPP2R1B
PRKAR1A
PSMD10
PTMA
QARS1
RAF1
RASSF1
RB1
RBL1
RBL2
RFC1
RFC4
RPL34
SENP3
SERTAD1
SETDB1
SHOX2
SKP1
SLBP
SMAD2
SMAD3
SNCA
SPOP
STK11
STUB1
TEAD2
TERT
TGFBR1
TK1
TP53
TRMT2A
TSC1
TSPYL2
UBE3A
UBTF
UHRF2
USP17L2
USP51
VTA1
WDR33
YBX3
ZBTB16
ZNF101
ZNF219
ZNF335
ZNF655
164 interacting genes:
ACVR1
ACVRL1
AMHR2
ANAPC5
AP2B1
ARHGAP15
ARHGAP31
ARHGEF6
ARL4D
ARL8B
ASH2L
AURKB
BAMBI
BMPR1B
BMPR2
BTBD2
CAV1
CD44
CDC20
CDC42EP4
CDK14
CDK17
CDK4
CDK6
CDKL1
CHN1
CHN2
CHUK
CLU
CSNK1A1
CSNK2A2
CTNNB1
CUL5
DAB2
DAPK2
DCAF12
DCAF6
DUSP13B
EIF2AK4
ENC1
ENG
FANCL
FBXL12
FBXO34
FKBP1A
FKBP1B
FNTA
GNA13
GNB2
GNB3
IKBKB
ITK
KATNB1
KCNK18
KLHL1
KLHL35
LIMS1
LITATS1
MAP3K20
MAP3K7
MYO3A
MYOC
MYT1L
NAT8
NEK6
NEK8
NKIRAS1
NRP1
NUAK2
NUP37
OSR1
OTUB1
OXSR1
PAK1
PARD6A
PIK3R1
PIK3R2
PLEK
PLEKHB1
PLEKHJ1
PLK4
PML
POMK
PPP2R2A
PPP3CC
PPP6C
PREB
PREX2
PRPF4
RAB13
RAB25
RAB33B
RAB34
RAB38
RAB3B
RAB6B
RAN
RAP2A
RASD2
RASL12
RGS19
RHEBL1
RHOA
RHOD
RHOG
RHOH
RHOJ
RHPN2
RNF130
RNF146
RNF5
RPAP3
RPS27A
RRH
RTKN
SAMD8
SAT2
SKAP2
SKI
SKIC8
SMAD1
SMAD2
SMAD3
SMAD4
SMAD6
SMAD7
SMURF2
SNTG1
SNX6
SOCS6
SQSTM1
STK35
STRAP
STUB1
STX8
STYXL1
TGFB1
TGFB2
TGFB3
TGFBR2
TGFBRAP1
TNNT1
TRAF6
TRAP1
TSC22D1
TSSK1B
TSSK4
TTC1
TTC27
TTPAL
UBA52
UBB
UBD
UBE2E3
UBE2Z
UBXN1
USP14
USP2
USP45
VEPH1
WDR13
WDR33
XIAP
ZFYVE9
Entrez ID
1019
7046
HPRD ID
00447
01822
Ensembl ID
ENSG00000135446
ENSG00000106799
Uniprot IDs
P11802
B4DXN7
B4DY26
F8W0K6
P36897
Q5T7S2
PDB IDs
2W96
2W99
2W9F
2W9Z
3G33
5FWK
5FWL
5FWM
5FWP
6P8E
6P8F
6P8G
6P8H
7SJ3
1B6C
1IAS
1PY5
1RW8
1VJY
2L5S
2PJY
2WOT
2WOU
2X7O
3FAA
3GXL
3HMM
3KCF
3KFD
3TZM
4X0M
4X2F
4X2G
4X2J
4X2K
4X2N
5E8S
5E8T
5E8U
5E8W
5E8X
5E8Z
5E90
5FRI
5QIK
5QIL
5QIM
5QTZ
5QU0
5USQ
6B8Y
6MAC
8YHF
8YHL
9B9F
9F6X
9FK5
Enriched GO Terms of Interacting Partners
?
Regulation Of Primary Metabolic Process
Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Nucleus
Regulation Of Cell Population Proliferation
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Cycle
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Regulation Of Catalytic Activity
Negative Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Signal Transduction
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Modification Process
Regulation Of Phosphorus Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Kinase Activity
Negative Regulation Of Apoptotic Process
Intracellular Signal Transduction
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Phosphorylation
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Nucleoplasm
Negative Regulation Of Cell Cycle
Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Mitotic Cell Cycle
Regulation Of Protein Kinase Activity
Regulation Of Protein Phosphorylation
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Cycle Process
Cellular Response To Stress
Protein Kinase Binding
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Regulation Of Intracellular Signal Transduction
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Signal Transduction
Intracellular Signaling Cassette
Signal Transduction
Protein Serine/threonine Kinase Activity
Nucleotide Binding
Protein Kinase Activity
Regulation Of Signaling
Regulation Of Cell Communication
Type I Transforming Growth Factor Beta Receptor Binding
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Intracellular Signal Transduction
Regulation Of SMAD Protein Signal Transduction
SMAD Binding
Cytosol
Kinase Activity
Response To Growth Factor
GTPase Activity
Cell Surface Receptor Signaling Pathway
Protein Modification Process
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of SMAD Protein Signal Transduction
Ubiquitin Protein Ligase Binding
Negative Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Protein Serine Kinase Activity
Positive Regulation Of Epithelial To Mesenchymal Transition
I-SMAD Binding
Modification-dependent Protein Catabolic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Proteolysis Involved In Protein Catabolic Process
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Epithelial To Mesenchymal Transition
GTP Binding
Regulation Of Cellular Response To Growth Factor Stimulus
Heteromeric SMAD Protein Complex
Transferase Activity
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Binding
SMAD Protein Signal Transduction
Post-translational Protein Modification
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Tagcloud (Intersection)
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