CDK4 and CCND2

Number of citations of the paper that reports this interaction (PMID 15169570)
17

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		CDK4	CCND2
Gene Name		cyclin-dependent kinase 4	cyclin D2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Tight Junction Nuclear Membrane Perinuclear Region Of Cytoplasm	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Membrane
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Cyclin Binding Protein Complex Binding	Protein Binding Protein Kinase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Lens Development In Camera-type Eye Chromatin Organization Protein Phosphorylation Signal Transduction Circadian Rhythm Positive Regulation Of Cell Proliferation Response To Toxic Substance Response To Lead Ion Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Organ Regeneration Response To Testosterone Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Translation Positive Regulation Of Cell Size Regulation Of Protein Kinase Activity Positive Regulation Of Fibroblast Proliferation Cell Division Response To Hyperoxia Negative Regulation Of Cell Cycle Arrest	Positive Regulation Of Protein Phosphorylation Cell Cycle Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division
Pathways		Meiotic recombination Chromatin organization Ubiquitin-dependent degradation of Cyclin D Cellular Senescence G1 Phase Senescence-Associated Secretory Phenotype (SASP) S Phase Oncogene Induced Senescence Cell Cycle, Mitotic Ubiquitin-dependent degradation of Cyclin D1 RMTs methylate histone arginines Cyclin D associated events in G1 Chromatin modifying enzymes Oxidative Stress Induced Senescence Transcriptional regulation of white adipocyte differentiation Mitotic G1-G1/S phases	Cyclin D associated events in G1 G1 Phase Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 21383967)	Colorectal cancer ( 23266556 23263487) Major depressive disorder ( 19107115 23377640) Obesity-related traits ( 23251661) QT interval (interaction) ( 23459443) Red blood cell count ( 20139978) Red blood cell traits ( 23222517)
Protein-Protein Interactions		90 interactors: ANKRD12 ANXA7 APLP1 APP ARID4A ATP5B BAG6 BCL11A BIRC5 BMPR1B BRCA1 CAMK1 CAPNS1 CCND1 CCND2 CCND3 CDC37 CDC45 CDC6 CDC7 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CDKN2D CEBPA CIB1 CNOT7 DAZAP2 DDAH2 DUSP9 FOXM1 GLI1 H1F0 HIST1H1A HIST1H1D HMGXB3 HOOK1 IFI27 IL15RA LUC7L2 MAPRE2 MARCKS MCM2 MYC MYOD1 MZF1 NCOA2 NOL12 ORC3 OTX2 PGD PKM POLD1 PPP2R1B PRKAR1A PSMD10 PTMA QARS RB1 RBL1 RBL2 RFC1 RFC4 RPL34 SENP3 SERTAD1 SETDB1 SHOX2 SKP1 SLBP SMAD2 SMAD3 SNCA TGFBR1 TK1 TRMT2A TSPYL2 UBTF UHRF2 VTA1 WDR33 ZBTB16 ZNF101 ZNF219 ZNF335 ZNF655 ZSCAN1	19 interactors: ABL1 AKAP8 CALM1 CALM2 CALM3 CDK4 CDK5 CDKN1A CDKN1B CDKN2A DMTF1 FBXL2 HIST1H1A NPDC1 PCGF2 PSMD10 RB1 RUNX1 SERTAD1
Entrez ID		1019	894
HPRD ID		00447	00451
Ensembl ID		ENSG00000135446	ENSG00000118971
Uniprot IDs		P11802 Q6LC83	P30279
PDB IDs		1LD2 2W96 2W99 2W9F 2W9Z 3G33
Enriched GO Terms of Interacting Partners?		Cell Cycle Regulation Of Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Kinase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Gene Expression Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Gene Expression Regulation Of Cell Proliferation Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cell Cycle RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Phosphorylation Gene Expression Negative Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Phosphorylation Chromosome Organization Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Regulation Of RNA Biosynthetic Process	Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Cell Cycle Regulation Of Cell Cycle Process Regulation Of Protein Phosphorylation Negative Regulation Of Phosphorylation Regulation Of Phosphorylation Negative Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Intracellular Transport Negative Regulation Of Cell Cycle Regulation Of Cellular Localization Positive Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Response To Corticosterone Cell Cycle Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Catalytic Activity Positive Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Process Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Response To Mineralocorticoid Positive Regulation Of Oxidoreductase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Fc Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transferase Activity Cell Cycle Arrest Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Response To Organic Cyclic Compound Detection Of Calcium Ion
Tagcloud ?		aberrantly acetylglucosaminyltransferase antigens bage ctl ecto fig fm3 fm57 gage gp100 immunogenic immunogenicity in4 maa mage mart melan melanocyte melanomas p15 pbl permitted pointing prame ref tab trp tyrosinase uncloned	associations blotting ccnd1 dab2 dact1 day detect displayed expressions fosl1 increasing jun mean pathway pcr placenta play promoting real relationship signaling spss target tissue tissues trend value western wnt
Tagcloud (Difference) ?		aberrantly acetylglucosaminyltransferase antigens bage ctl ecto fig fm3 fm57 gage gp100 immunogenic immunogenicity in4 maa mage mart melan melanocyte melanomas p15 pbl permitted pointing prame ref tab trp tyrosinase uncloned	associations blotting ccnd1 dab2 dact1 day detect displayed expressions fosl1 increasing jun mean pathway pcr placenta play promoting real relationship signaling spss target tissue tissues trend value western wnt
Tagcloud (Intersection) ?