CDK4 and ARID4A

Number of citations of the paper that reports this interaction (PubMedID 21148318)
61

Data Source:
BioGRID (enzymatic study)

		CDK4	ARID4A
Description		cyclin dependent kinase 4	AT-rich interaction domain 4A
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Cytosol Bicellular Tight Junction Membrane Nuclear Membrane Cyclin D1-CDK4 Complex Cyclin D2-CDK4 Complex Cyclin D3-CDK4 Complex	Nucleus Nucleoplasm Plasma Membrane Transcription Repressor Complex Sin3-type Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Transferase Activity Cyclin Binding Protein Serine Kinase Activity	Transcription Cis-regulatory Region Binding DNA Binding Double-stranded DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Proliferation Cell Division Regulation Of Cell Cycle Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4 Cellular Response To Phorbol 13-acetate 12-myristate Cellular Response To Ionomycin	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Spermatogenesis Cell Differentiation Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Erythrocyte Development Genomic Imprinting Establishment Of Sertoli Cell Barrier Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance
Pathways		SCF(Skp2)-mediated degradation of p27/p21 Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Cyclin D associated events in G1 Ubiquitin-dependent degradation of Cyclin D Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates Cell Cycle Transcriptional regulation by RUNX2 Meiotic recombination Transcriptional regulation of granulopoiesis Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Drug-mediated inhibition of CDK4/CDK6 activity SPOP-mediated proteasomal degradation of PD-L1(CD274)	HDACs deacetylate histones Potential therapeutics for SARS
Drugs		Purvalanol Alvocidib Palbociclib Ribociclib Abemaciclib Fostamatinib Trilaciclib
Diseases		Malignant melanoma Glioma Cervical cancer
GWAS		Brain morphology (MOSTest) ( 32665545) Celiac disease or Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 24390342 30423114)	Age at first sexual intercourse ( 34211149) Alcohol consumption (drinks per week) ( 30679032) Alcohol consumption in current drinkers ( 28937693) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778 33020668) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Problematic alcohol use ( 32451486) Venous thromboembolism ( 31420334) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		136 interacting genes: AGAP2 AKT1 ANKRD12 ANXA7 APLP1 APP ARAF ARID4A ARNT ATP5F1B BAG6 BCL11A BECN1 BIRC5 BMPR1B BRCA1 CAMK1 CAPNS1 CCND1 CCND2 CCND3 CCNE1 CD44 CDC37 CDC45 CDC6 CDC7 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CDKN2D CEBPA CIB1 CNOT7 CNTN2 DAZAP2 DDAH2 DUSP9 EIF4EBP2 EPHA2 ERBB2 FARP2 FBXO8 FGFR4 FOXM1 FZR1 GLIS2 GRM1 H1-0 H1-1 H1-3 HGF HIF1A HMGXB3 HOOK1 HSP90AB1 IFI27 IGF1R IKZF3 IL15RA INCA1 KDELR2 LATS2 LNX2 LUC7L2 MAP2K3 MAP2K5 MAP3K5 MAPK14 MAPRE2 MARCKS MCM2 MDM4 MET MYOD1 MZF1 NCOA2 NF2 NOL12 OGDHL ORC3 OTX2 PDGFRA PGD PIAS1 PKM POLD1 PPP2R1B PRKAR1A PSMD10 PTMA QARS1 RAF1 RASSF1 RB1 RBL1 RBL2 RFC1 RFC4 RPL34 SENP3 SERTAD1 SETDB1 SHOX2 SKP1 SLBP SMAD2 SMAD3 SNCA SPOP STK11 STUB1 TEAD2 TERT TGFBR1 TK1 TP53 TRMT2A TSC1 TSPYL2 UBE3A UBTF UHRF2 USP17L2 USP51 VTA1 WDR33 YBX3 ZBTB16 ZNF101 ZNF219 ZNF335 ZNF655	15 interacting genes: BRMS1 CCNA2 CCNB1 CCND1 CCNE1 CDK1 CDK2 CDK4 EID1 H3C14 H4C16 HDAC1 HDAC2 HDAC3 SIN3A
Entrez ID		1019	5926
HPRD ID		00447	01575
Ensembl ID		ENSG00000135446	ENSG00000032219
Uniprot IDs		P11802	P29374 Q05CG0
PDB IDs		2W96 2W99 2W9F 2W9Z 3G33 5FWK 5FWL 5FWM 5FWP 6P8E 6P8F 6P8G 6P8H 7SJ3	2LCC 2MAM 2YRV 6BPH 6L87 7SMC 7V8N
Enriched GO Terms of Interacting Partners?		Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of Cell Population Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Catalytic Activity Negative Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Kinase Activity Negative Regulation Of Apoptotic Process Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Phosphorylation Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Nucleoplasm Negative Regulation Of Cell Cycle Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of RNA Metabolic Process Negative Regulation Of Cell Population Proliferation Regulation Of Cell Cycle Process Cellular Response To Stress Protein Kinase Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process	Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Mitotic Cell Cycle Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Protein Lysine Delactylase Activity Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mitotic Cell Cycle Regulation Of RNA Metabolic Process Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of Mitotic Cell Cycle Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Biosynthetic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process NF-kappaB Binding Cyclin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Histone Deacetylase Complex Cell Division Positive Regulation Of Cell Cycle Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Histone Deacetylase Binding Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Metabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Chromatin Organization Cell Cycle G2/M Phase Transition
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