CDK4 and CCNE1

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		CDK4	CCNE1
Description		cyclin dependent kinase 4	cyclin E1
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Cytosol Bicellular Tight Junction Membrane Nuclear Membrane Cyclin D1-CDK4 Complex Cyclin D2-CDK4 Complex Cyclin D3-CDK4 Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Cyclin E1-CDK2 Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Transferase Activity Cyclin Binding Protein Serine Kinase Activity	Protein Binding Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Proliferation Cell Division Regulation Of Cell Cycle Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4 Cellular Response To Phorbol 13-acetate 12-myristate Cellular Response To Ionomycin	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance DNA Replication Initiation Protein Phosphorylation Homologous Chromosome Pairing At Meiosis Wnt Signaling Pathway Regulation Of Protein Localization Cell Division Regulation Of Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mesenchymal Stem Cell Proliferation
Pathways		SCF(Skp2)-mediated degradation of p27/p21 Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Cyclin D associated events in G1 Ubiquitin-dependent degradation of Cyclin D Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates Cell Cycle Transcriptional regulation by RUNX2 Meiotic recombination Transcriptional regulation of granulopoiesis Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Drug-mediated inhibition of CDK4/CDK6 activity SPOP-mediated proteasomal degradation of PD-L1(CD274)	G0 and Early G1 SCF(Skp2)-mediated degradation of p27/p21 DNA Damage/Telomere Stress Induced Senescence Association of TriC/CCT with target proteins during biosynthesis TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response PTK6 Regulates Cell Cycle Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) RHOBTB3 ATPase cycle
Drugs		Purvalanol Alvocidib Palbociclib Ribociclib Abemaciclib Fostamatinib Trilaciclib
Diseases		Malignant melanoma Glioma Cervical cancer	Laryngeal cancer Gastric cancer
GWAS		Brain morphology (MOSTest) ( 32665545) Celiac disease or Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 24390342 30423114)	Adult body size ( 32376654) Bladder cancer ( 20972438 24163127) Body mass index ( 25673413) Breast cancer ( 29058716) Breast cancer (estrogen-receptor negative) ( 29058716) Diastolic blood pressure ( 27841878 28135244) Medication use (diuretics) ( 31015401) Response to fenofibrate (total cholesterol levels) ( 27002377) Spatial processing ( 31596458) Walking pace ( 33128006)
Interacting Genes		136 interacting genes: AGAP2 AKT1 ANKRD12 ANXA7 APLP1 APP ARAF ARID4A ARNT ATP5F1B BAG6 BCL11A BECN1 BIRC5 BMPR1B BRCA1 CAMK1 CAPNS1 CCND1 CCND2 CCND3 CCNE1 CD44 CDC37 CDC45 CDC6 CDC7 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CDKN2D CEBPA CIB1 CNOT7 CNTN2 DAZAP2 DDAH2 DUSP9 EIF4EBP2 EPHA2 ERBB2 FARP2 FBXO8 FGFR4 FOXM1 FZR1 GLIS2 GRM1 H1-0 H1-1 H1-3 HGF HIF1A HMGXB3 HOOK1 HSP90AB1 IFI27 IGF1R IKZF3 IL15RA INCA1 KDELR2 LATS2 LNX2 LUC7L2 MAP2K3 MAP2K5 MAP3K5 MAPK14 MAPRE2 MARCKS MCM2 MDM4 MET MYOD1 MZF1 NCOA2 NF2 NOL12 OGDHL ORC3 OTX2 PDGFRA PGD PIAS1 PKM POLD1 PPP2R1B PRKAR1A PSMD10 PTMA QARS1 RAF1 RASSF1 RB1 RBL1 RBL2 RFC1 RFC4 RPL34 SENP3 SERTAD1 SETDB1 SHOX2 SKP1 SLBP SMAD2 SMAD3 SNCA SPOP STK11 STUB1 TEAD2 TERT TGFBR1 TK1 TP53 TRMT2A TSC1 TSPYL2 UBE3A UBTF UHRF2 USP17L2 USP51 VTA1 WDR33 YBX3 ZBTB16 ZNF101 ZNF219 ZNF335 ZNF655	71 interacting genes: AKT1 AR ARHGEF5 ARID4A ARIH1 ARNT AURKA BRCA2 BTRC CABLES1 CALM1 CCND2 CCT4 CDC25A CDC6 CDK1 CDK2 CDK3 CDK4 CDK6 CDKN1A CDKN2A CDKN2B CDKN2C COIL CUL3 FBXW7 FGFR4 FOXM1 FZR1 GLIS2 GMNC GRM1 GSK3B H1-0 H1-1 H1-5 HERC5 KAT2A KPNB1 LATS2 LINC00664 MARCKS MCM3 MRE11 MYBL2 MYC NBN NF2 PIN1 POLD1 PRC1 PRKAR1A PTPA RASSF1 RB1 RBL1 RBL2 REL RHOBTB3 RRN3 SKP2 SMARCA4 SMARCC1 SMARCD3 SPOP STK11 TERT TP73 TSC1 UBTF
Entrez ID		1019	898
HPRD ID		00447	00455
Ensembl ID		ENSG00000135446	ENSG00000105173
Uniprot IDs		P11802	A0A0G3DHS8 P24864 V5W5X2
PDB IDs		2W96 2W99 2W9F 2W9Z 3G33 5FWK 5FWL 5FWM 5FWP 6P8E 6P8F 6P8G 6P8H 7SJ3	1W98 5L2W 7KJS 7XQK 8H4R 8H6P 8H6T 8VQ3 8VQ4
Enriched GO Terms of Interacting Partners?		Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of Cell Population Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Catalytic Activity Negative Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Kinase Activity Negative Regulation Of Apoptotic Process Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Phosphorylation Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Nucleoplasm Negative Regulation Of Cell Cycle Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of RNA Metabolic Process Negative Regulation Of Cell Population Proliferation Regulation Of Cell Cycle Process Cellular Response To Stress Protein Kinase Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process	Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Nucleus Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Regulation Of DNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Cell Population Proliferation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of DNA Metabolic Process Cyclin Binding Negative Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Cell Population Proliferation Cellular Response To Stress Cell Division Regulation Of Protein Localization To Nucleus Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Modification Process Regulation Of Signal Transduction Regulation Of Chromosome Organization Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Macromolecule Metabolic Process G2/M Transition Of Mitotic Cell Cycle
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