CDK4 and VTA1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CDK4	VTA1
Gene Name		cyclin-dependent kinase 4	vesicle (multivesicular body) trafficking 1
Image
Gene Ontology Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Tight Junction Nuclear Membrane Perinuclear Region Of Cytoplasm	Cytosol Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Cyclin Binding Protein Complex Binding	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Lens Development In Camera-type Eye Chromatin Organization Protein Phosphorylation Signal Transduction Circadian Rhythm Positive Regulation Of Cell Proliferation Response To Toxic Substance Response To Lead Ion Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Organ Regeneration Response To Testosterone Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Translation Positive Regulation Of Cell Size Regulation Of Protein Kinase Activity Positive Regulation Of Fibroblast Proliferation Cell Division Response To Hyperoxia Negative Regulation Of Cell Cycle Arrest	Protein Transport Viral Process Endosomal Transport Viral Life Cycle Membrane Organization
Pathways		Meiotic recombination Chromatin organization Ubiquitin-dependent degradation of Cyclin D Cellular Senescence G1 Phase Senescence-Associated Secretory Phenotype (SASP) S Phase Oncogene Induced Senescence Cell Cycle, Mitotic Ubiquitin-dependent degradation of Cyclin D1 RMTs methylate histone arginines Cyclin D associated events in G1 Chromatin modifying enzymes Oxidative Stress Induced Senescence Transcriptional regulation of white adipocyte differentiation Mitotic G1-G1/S phases	HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 21383967)	Retinal vascular caliber ( 21060863)
Protein-Protein Interactions		90 interactors: ANKRD12 ANXA7 APLP1 APP ARID4A ATP5B BAG6 BCL11A BIRC5 BMPR1B BRCA1 CAMK1 CAPNS1 CCND1 CCND2 CCND3 CDC37 CDC45 CDC6 CDC7 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CDKN2D CEBPA CIB1 CNOT7 DAZAP2 DDAH2 DUSP9 FOXM1 GLI1 H1F0 HIST1H1A HIST1H1D HMGXB3 HOOK1 IFI27 IL15RA LUC7L2 MAPRE2 MARCKS MCM2 MYC MYOD1 MZF1 NCOA2 NOL12 ORC3 OTX2 PGD PKM POLD1 PPP2R1B PRKAR1A PSMD10 PTMA QARS RB1 RBL1 RBL2 RFC1 RFC4 RPL34 SENP3 SERTAD1 SETDB1 SHOX2 SKP1 SLBP SMAD2 SMAD3 SNCA TGFBR1 TK1 TRMT2A TSPYL2 UBTF UHRF2 VTA1 WDR33 ZBTB16 ZNF101 ZNF219 ZNF335 ZNF655 ZSCAN1	17 interactors: APP CBS CDK4 CHMP5 DPPA2 KCTD13 KLHL12 LYST MAGEA11 MBIP NBR1 NECAB2 NGFRAP1 RABAC1 RPIA SSSCA1 ZBTB16
Entrez ID		1019	51534
HPRD ID		00447	09855
Ensembl ID		ENSG00000135446
Uniprot IDs		P11802 Q6LC83	E7ETQ7 Q9NP79
PDB IDs		1LD2 2W96 2W99 2W9F 2W9Z 3G33	2LXL 2LXM
Enriched GO Terms of Interacting Partners?		Cell Cycle Regulation Of Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Kinase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Gene Expression Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Gene Expression Regulation Of Cell Proliferation Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cell Cycle RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Phosphorylation Gene Expression Negative Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Phosphorylation Chromosome Organization Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Regulation Of RNA Biosynthetic Process	Cell Division Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Lysosome Organization Positive Regulation Of Cell Cycle Phase Transition Cysteine Biosynthetic Process From Serine Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Homocysteine Catabolic Process Cysteine Biosynthetic Process Via Cystathionine Negative Regulation Of Cell Differentiation Organelle Organization Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Synaptic Growth At Neuromuscular Junction Mast Cell Secretory Granule Organization Transsulfuration Regulation Of Mitotic Cell Cycle Vacuole Organization Collateral Sprouting In Absence Of Injury Cysteine Biosynthetic Process L-cysteine Catabolic Process Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle L-serine Catabolic Process Pentose-phosphate Shunt, Non-oxidative Branch Regulation Of Cell Cycle Process Positive Regulation Of NK T Cell Differentiation Collateral Sprouting Axon Midline Choice Point Recognition Hydrogen Sulfide Metabolic Process Positive Regulation Of Peptidase Activity Endosome Transport Via Multivesicular Body Sorting Pathway Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Male Germ-line Stem Cell Asymmetric Division Regulation Of Cellular Protein Metabolic Process Axon Choice Point Recognition Protein Ubiquitination Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cysteine Metabolic Process Secretion Of Lysosomal Enzymes Positive Regulation Of Cell Death Protein Modification By Small Protein Conjugation Regulation Of Response To Osmotic Stress Regulation Of Mitotic Spindle Assembly Regulation Of Signaling Homocysteine Metabolic Process Phospholipid Homeostasis Neuron Remodeling
Tagcloud ?		aberrantly acetylglucosaminyltransferase antigens bage ctl ecto fig fm3 fm57 gage gp100 immunogenic immunogenicity in4 maa mage mart melan melanocyte melanomas p15 pbl permitted pointing prame ref tab trp tyrosinase uncloned	abscission atpase budding carboxyl cofactor compensatory coordinating cytokinesis endosomal enveloped escrt escrts helices hydrolysis input intergenic lip5 modulates multivesicular oligomer oligomerization rational sbp sorting stimulatory uncovered vps4 vse vsl
Tagcloud (Difference) ?		aberrantly acetylglucosaminyltransferase antigens bage ctl ecto fig fm3 fm57 gage gp100 immunogenic immunogenicity in4 maa mage mart melan melanocyte melanomas p15 pbl permitted pointing prame ref tab trp tyrosinase uncloned	abscission atpase budding carboxyl cofactor compensatory coordinating cytokinesis endosomal enveloped escrt escrts helices hydrolysis input intergenic lip5 modulates multivesicular oligomer oligomerization rational sbp sorting stimulatory uncovered vps4 vse vsl
Tagcloud (Intersection) ?