RBM5 and LIG4

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid)

		RBM5	LIG4
Gene Name		RNA binding motif protein 5	ligase IV, DNA, ATP-dependent
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex	Condensed Chromosome Nucleus Nucleoplasm Cytoplasm Plasma Membrane Focal Adhesion DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Nonhomologous End Joining Complex
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Poly(A) RNA Binding	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Protein C-terminus Binding Ligase Activity Metal Ion Binding
	Biological Process	Spliceosomal Complex Assembly Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Processing Apoptotic Process Negative Regulation Of Cell Proliferation RNA Splicing Gene Expression Positive Regulation Of Apoptotic Process	Single Strand Break Repair In Utero Embryonic Development Pro-B Cell Differentiation DNA Ligation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Central Nervous System Development Cell Proliferation Response To X-ray Response To Gamma Radiation Viral Process T Cell Differentiation In Thymus V(D)J Recombination Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Somatic Stem Cell Maintenance Negative Regulation Of Neuron Apoptotic Process Isotype Switching Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis DNA Ligation Involved In DNA Recombination DNA Ligation Involved In DNA Repair Chromosome Organization Cell Division Neuron Apoptotic Process Cellular Response To Lithium Ion DNA Biosynthetic Process Establishment Of Integrated Proviral Latency
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway	HIV Life Cycle Nonhomologous End-joining (NHEJ) HIV Infection Integration of provirus Double-Strand Break Repair 2-LTR circle formation Early Phase of HIV Life Cycle
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder and conduct disorder ( 18951430)
Protein-Protein Interactions		9 interactors: BCL2L1 GAPDH ILF3 LIG4 LRIF1 LSM8 WBP11 WDR77 ZDHHC17	103 interactors: ACTG1 AFTPH AGAP4 ALMS1 AMZ2P1 ANAPC10 APLF ASPM ATM ATP6V0D1 ATR B9D1 CAP1 CCDC176 CLU COL1A2 COMMD1 COX1 COX2 COX3 CPNE1 CREBBP CTSK DDX19A DGUOK DPP3 EIF2AK1 EIF3I EIF4A1 EIF4G3 ENO1 ETF1 FAM214A FBLL1 FIP1L1 GAPDH GGH GPANK1 GRHPR GUSBP3 GZMK HMGN1 HNRNPA2B1 IPP KDELR1 KIF3A LAP3 MAP2K2 MCM4 MCRS1 MRPS18C ND1 ND4 ND5 NDUFA13 NDUFB10 NEU1 NHEJ1 NOMO3 NPC2 OGFOD1 OSTM1 OXR1 PA2G4 PALLD PEX10 PGP PHF10 PMS2P1 PPIA PRKDC PSMA6 RBM5 RHBDD2 RPL11 RPS19BP1 RUVBL2 SEMA4G SMC2 SNX3 SOWAHC SRSF2 SYCP3 THOC5 TLE4 TOP1 TP53BP1 TPT1 TRAPPC3 TSFM UBB UBE2L3 UFSP2 UNC119 VKORC1 WARS WBP1L WDR20 XRCC4 ZFAND2A ZNF428 ZSCAN18 ZWINT
Entrez ID		10181	3981
HPRD ID		06052	03500
Ensembl ID		ENSG00000003756	ENSG00000174405
Uniprot IDs		P52756	P49917
PDB IDs		2LK0 2LK1 2LKZ	1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP
Enriched GO Terms of Interacting Partners?		Neuron Apoptotic Process Neuron Death Response To Gamma Radiation RNA Splicing RNA Metabolic Process DNA Ligation Involved In DNA Recombination Peptidyl-cysteine S-trans-nitrosylation Apoptotic Process In Bone Marrow Negative Regulation Of Translation MRNA Processing MRNA Metabolic Process RNA Processing Response To Ionizing Radiation Suppression By Virus Of Host Apoptotic Process Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Peptidyl-cysteine S-nitrosylation Negative Regulation Of Neuron Apoptotic Process Lagging Strand Elongation Pro-B Cell Differentiation Nucleobase-containing Compound Metabolic Process Response To Cycloheximide Cellular Process Regulating Host Cell Cycle In Response To Virus Negative Regulation Of Neuron Death Establishment Of Integrated Proviral Latency Positive Regulation Of Cell Proliferation Heterocycle Metabolic Process Negative Regulation Of Execution Phase Of Apoptosis Cellular Aromatic Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Neuron Apoptotic Process Immunoglobulin V(D)J Recombination Establishment Of Viral Latency T Cell Receptor V(D)J Recombination DNA Ligation Involved In DNA Repair Response To Virus Cellular Nitrogen Compound Metabolic Process Regulation Of Translation Lymphoid Progenitor Cell Differentiation Apoptotic Process Gene Expression Cellular Response To Virus Regulation Of Neuron Death Modulation By Virus Of Host Process Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Programmed Cell Death Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane DNA Ligation Negative Regulation Of Anoikis Cell Death	Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Organelle Organization DNA Metabolic Process Positive Regulation Of Ligase Activity Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Double-strand Break Repair DNA Repair DNA Recombination Cellular Response To Stress Metabolic Process Cell Cycle Process Positive Regulation Of Protein Ubiquitination Cellular Response To DNA Damage Stimulus Response To Stress Regulation Of Protein Catabolic Process Cell Cycle Checkpoint Mitochondrial Electron Transport, NADH To Ubiquinone Mitotic Cell Cycle Checkpoint Positive Regulation Of Signal Transduction By P53 Class Mediator Viral Process Response To Radiation Mitotic Cell Cycle Process Protein Metabolic Process Negative Regulation Of Cell Cycle Response To Gamma Radiation Posttranscriptional Regulation Of Gene Expression Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Respiratory Electron Transport Chain Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Translation Double-strand Break Repair Via Nonhomologous End Joining Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Proteasomal Protein Catabolic Process Mitotic Cell Cycle Electron Transport Chain Regulation Of Protein Ubiquitination Regulation Of Response To DNA Damage Stimulus Cell Cycle V(D)J Recombination Pro-B Cell Differentiation Cellular Protein Metabolic Process Generation Of Precursor Metabolites And Energy Positive Regulation Of Ubiquitin-protein Transferase Activity
Tagcloud ?		accompanied active apoptotic apparently bax caspase cord demonstrating employed establish expressions immunofluorescent labeling localization location modulating motif nervous neuronal pc12 probe promotes regulating sci spinal suppressor traumatic trigger unregulated	ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig3 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining
Tagcloud (Difference) ?		accompanied active apoptotic apparently bax caspase cord demonstrating employed establish expressions immunofluorescent labeling localization location modulating motif nervous neuronal pc12 probe promotes regulating sci spinal suppressor traumatic trigger unregulated	ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig3 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining
Tagcloud (Intersection) ?