RBM5 and PARD3B

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		RBM5	PARD3B
Description		RNA binding motif protein 5	par-3 family cell polarity regulator beta
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytosol	Adherens Junction Bicellular Tight Junction Cell Cortex Endomembrane System Membrane Apical Plasma Membrane Cell Junction Protein-containing Complex Apical Junction Complex Anchoring Junction
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Phosphatidylinositol Binding
	Biological Process	Spliceosomal Complex Assembly Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing Apoptotic Process Negative Regulation Of Cell Population Proliferation RNA Splicing Positive Regulation Of Apoptotic Process	Microtubule Cytoskeleton Organization Cell Adhesion Intracellular Protein Localization Establishment Of Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Division Establishment Of Centrosome Localization
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Age at first birth ( 27798627) Alanine aminotransferase levels ( 33547301) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from tea ( 33287642) Cortical surface area (MOSTest) ( 32665545) Dentures ( 31235808) Extremely high intelligence ( 29520040) HDL cholesterol ( 24097068) HDL cholesterol levels ( 30698716 28334899) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Morning person ( 30696823) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Adult body size ( 32376654) AIDS progression ( 21502085) Aluminium levels ( 26025379) Attention deficit hyperactivity disorder ( 30563984) Autism ( 22843504) Body mass index ( 28892062) Craniofacial microsomia ( 26853712) Diisocyanate-induced asthma ( 25918132) General risk tolerance (MTAG) ( 30643258) HDL levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Hip circumference adjusted for BMI ( 28552196) Hippocampal volume ( 25625606) Idiopathic dilated cardiomyopathy ( 29495422) Intracranial aneurysm ( 29531279) Intraocular pressure ( 29617998 31959993 30054594 29785010) Knee osteoarthritis ( 18471798) Nicotine dependence symptom count ( 25555482) Post bronchodilator FEV1/FVC ratio ( 26634245) Triglyceride levels ( 32902719) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		32 interacting genes: BCL2L1 CASK CIP2A CREBBP DCX DDX17 GAPDH ILF3 KIF19 KIF9 LIG4 LRIF1 LSM8 MED1 MEOX1 MEOX2 MIRLET7D MIRLET7E MIRLET7G MIRLET7I MLYCD NDEL1 PARD3B PCM1 PKP2 POMP RBM14 RNF10 SHANK3 WBP11 WDR77 ZDHHC17	9 interacting genes: CASK GAA INSC MARK2 PARD6B RBM5 RPS6KA1 YWHAE YWHAG
Entrez ID		10181	117583
HPRD ID		06052	09795
Ensembl ID		ENSG00000003756	ENSG00000116117
Uniprot IDs		P52756	Q8TEW8
PDB IDs		2LK0 2LK1 2LKZ 5MF9 5MFY 7PCV 7PDV
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Somite Specification Regulatory NcRNA-mediated Gene Silencing Kinesin Complex RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Microtubule Binding Post-transcriptional Gene Silencing Transcription Coactivator Activity Microtubule Cytoskeleton Organization Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell MRNA Base-pairing Post-transcriptional Repressor Activity Positive Regulation Of RNA Metabolic Process Organelle Organization Cytoplasm Segment Specification Somite Development Nuclear Retinoic Acid Receptor Binding RNA Splicing MRNA Splicing, Via Spliceosome Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Ribonucleoprotein Complex RNA Splicing, Via Transesterification Reactions Hematopoietic Stem Cell Differentiation Post-transcriptional Regulation Of Gene Expression MRNA Metabolic Process Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Keratinocyte Proliferation Negative Regulation Of Gene Expression Neuron Apoptotic Process Regulation Of MRNA Splicing, Via Spliceosome MRNA Processing	Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Autolysosome Lumen Vacuolar Sequestering TORC1 Signaling Protein Domain Specific Binding Protein Sequestering Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Sucrose Metabolic Process Maltose Metabolic Process Negative Regulation Of TOR Signaling TOR Signaling Regulation Of Heart Rate By Hormone Focal Adhesion
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