RBM5 and WDR77

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid)

		RBM5	WDR77
Description		RNA binding motif protein 5	WD repeat domain 77
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytosol	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cul4B-RING E3 Ubiquitin Ligase Complex Methylosome Transferase Complex
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Transcription Coactivator Activity Protein Binding Methyl-CpG Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Spliceosomal Complex Assembly Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing Apoptotic Process Negative Regulation Of Cell Population Proliferation RNA Splicing Positive Regulation Of Apoptotic Process	Protein Polyubiquitination Spliceosomal SnRNP Assembly Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Oocyte Axis Specification Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of MRNA Splicing, Via Spliceosome Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Pathways		mRNA Splicing - Major Pathway	snRNP Assembly RMTs methylate histone arginines
Drugs
Diseases
GWAS		Age at first birth ( 27798627) Alanine aminotransferase levels ( 33547301) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from tea ( 33287642) Cortical surface area (MOSTest) ( 32665545) Dentures ( 31235808) Extremely high intelligence ( 29520040) HDL cholesterol ( 24097068) HDL cholesterol levels ( 30698716 28334899) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Morning person ( 30696823) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		32 interacting genes: BCL2L1 CASK CIP2A CREBBP DCX DDX17 GAPDH ILF3 KIF19 KIF9 LIG4 LRIF1 LSM8 MED1 MEOX1 MEOX2 MIRLET7D MIRLET7E MIRLET7G MIRLET7I MLYCD NDEL1 PARD3B PCM1 PKP2 POMP RBM14 RNF10 SHANK3 WBP11 WDR77 ZDHHC17	46 interacting genes: AQR BAG2 CDK19 CDK8 CLNS1A CREBBP CTDP1 EIF4A1 GLI1 GPKOW H2AC21 HNRNPM LSM3 NKX3-1 PCBP2 PDCD4 PPIL1 PPP1R8 PQBP1 PRKG1 PRKG2 PRMT5 QKI RBM5 SAP30BP SF1 SF3A1 SF3B4 SIRT7 SMAD1 SMYD1 SNRPB SNRPC SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SUZ12 THOC1 TOE1 UBC YWHAB YWHAQ ZMYND19 ZNF207
Entrez ID		10181	79084
HPRD ID		06052	14387
Ensembl ID		ENSG00000003756	ENSG00000116455
Uniprot IDs		P52756	A0A024R0H7 Q9BQA1
PDB IDs		2LK0 2LK1 2LKZ 5MF9 5MFY 7PCV 7PDV	4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S 6RLL 6RLQ 6UGH 6UXX 6UXY 6V0N 6V0O 6V0P 7BO7 7KIB 7KIC 7KID 7L1G 7M05 7MX7 7MXA 7MXC 7MXG 7MXN 7S0U 7S1P 7S1Q 7S1R 7S1S 7SER 7SES 7U30 7UOH 7UY1 7UYF 7ZUP 7ZUQ 7ZUU 7ZUY 7ZV2 7ZVL 7ZVU 8CSG 8CTB 8CYI 8G1U 8VEO 8VET 8VEU 8VEW 8VEX 8VEY 8X6L 9C10 9DOD 9E3A 9E3B 9EYU 9EYV 9EYW 9EYX 9MGL 9MGM 9MGN 9MGP 9MGQ 9MGR 9N3N 9N3O 9N3P 9N3Q 9N3R
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Somite Specification Regulatory NcRNA-mediated Gene Silencing Kinesin Complex RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Microtubule Binding Post-transcriptional Gene Silencing Transcription Coactivator Activity Microtubule Cytoskeleton Organization Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell MRNA Base-pairing Post-transcriptional Repressor Activity Positive Regulation Of RNA Metabolic Process Organelle Organization Cytoplasm Segment Specification Somite Development Nuclear Retinoic Acid Receptor Binding RNA Splicing MRNA Splicing, Via Spliceosome Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Ribonucleoprotein Complex RNA Splicing, Via Transesterification Reactions Hematopoietic Stem Cell Differentiation Post-transcriptional Regulation Of Gene Expression MRNA Metabolic Process Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Keratinocyte Proliferation Negative Regulation Of Gene Expression Neuron Apoptotic Process Regulation Of MRNA Splicing, Via Spliceosome MRNA Processing	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex RNA Splicing MRNA Processing MRNA Metabolic Process Methylosome RNA Processing RNA Metabolic Process Spliceosomal Complex Assembly PICln-Sm Protein Complex Catalytic Step 2 Spliceosome U2-type Prespliceosome Assembly Spliceosomal SnRNP Assembly U2 SnRNP Protein-RNA Complex Assembly Nucleic Acid Metabolic Process U2-type Spliceosomal Complex RNA Binding 7-methylguanosine Cap Hypermethylation U2-type Catalytic Step 2 Spliceosome U2-type Precatalytic Spliceosome Nucleoplasm U1 SnRNP Nucleus U4 SnRNP U12-type Spliceosomal Complex Nucleobase-containing Compound Metabolic Process Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex Precatalytic Spliceosome U5 SnRNP U4/U6 X U5 Tri-snRNP Complex Macromolecule Metabolic Process U7 SnRNP Ribonucleoprotein Complex MRNA Binding Macromolecule Methylation Methylation RNA Methylation Commitment Complex Protein-containing Complex Assembly Nucleic Acid Binding Protein-containing Complex Organization RNA Modification CGMP-dependent Protein Kinase Activity MRNA Cis Splicing, Via Spliceosome U2-type Prespliceosome Telomerase Holoenzyme Complex Histone Pre-mRNA DCP Binding
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