RBM5 and WDR77

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid)

		RBM5	WDR77
Gene Name		RNA binding motif protein 5	WD repeat domain 77
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Methylosome
	Molecular Function	Nucleotide Binding DNA Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Poly(A) RNA Binding	Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity
	Biological Process	Spliceosomal Complex Assembly Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Processing Apoptotic Process Negative Regulation Of Cell Proliferation RNA Splicing Gene Expression Positive Regulation Of Apoptotic Process	Spliceosomal SnRNP Assembly Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Gene Expression NcRNA Metabolic Process Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway	Chromatin modifying enzymes snRNP Assembly Chromatin organization Metabolism of non-coding RNA RMTs methylate histone arginines
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: BCL2L1 GAPDH ILF3 LIG4 LRIF1 LSM8 WBP11 WDR77 ZDHHC17	35 interactors: AQR BAG2 COPRS CTDP1 GPKOW HIST2H2AB HNRNPM LSM3 NKX3-1 PCBP2 PPIL1 PPP1R8 PQBP1 PRMT5 QKI RBM5 SAP30BP SF1 SF3A1 SF3B4 SMAD1 SMYD1 SNRPB SNRPC SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SUZ12 THOC1 TOE1 YWHAB YWHAQ ZNF207
Entrez ID		10181	79084
HPRD ID		06052	14387
Ensembl ID		ENSG00000003756	ENSG00000116455
Uniprot IDs		P52756	B4DP38 Q9BQA1
PDB IDs		2LK0 2LK1 2LKZ	4GQB
Enriched GO Terms of Interacting Partners?		Neuron Apoptotic Process Neuron Death Response To Gamma Radiation RNA Splicing RNA Metabolic Process DNA Ligation Involved In DNA Recombination Peptidyl-cysteine S-trans-nitrosylation Apoptotic Process In Bone Marrow Negative Regulation Of Translation MRNA Processing MRNA Metabolic Process RNA Processing Response To Ionizing Radiation Suppression By Virus Of Host Apoptotic Process Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Peptidyl-cysteine S-nitrosylation Negative Regulation Of Neuron Apoptotic Process Lagging Strand Elongation Pro-B Cell Differentiation Nucleobase-containing Compound Metabolic Process Response To Cycloheximide Cellular Process Regulating Host Cell Cycle In Response To Virus Negative Regulation Of Neuron Death Establishment Of Integrated Proviral Latency Positive Regulation Of Cell Proliferation Heterocycle Metabolic Process Negative Regulation Of Execution Phase Of Apoptosis Cellular Aromatic Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Neuron Apoptotic Process Immunoglobulin V(D)J Recombination Establishment Of Viral Latency T Cell Receptor V(D)J Recombination DNA Ligation Involved In DNA Repair Response To Virus Cellular Nitrogen Compound Metabolic Process Regulation Of Translation Lymphoid Progenitor Cell Differentiation Apoptotic Process Gene Expression Cellular Response To Virus Regulation Of Neuron Death Modulation By Virus Of Host Process Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Programmed Cell Death Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane DNA Ligation Negative Regulation Of Anoikis Cell Death	RNA Splicing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing MRNA Metabolic Process Gene Expression RNA Metabolic Process Ribonucleoprotein Complex Assembly Spliceosomal SnRNP Assembly Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Ribonucleoprotein Complex Biogenesis Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecular Complex Assembly Spliceosomal Complex Assembly Transcription, DNA-templated Histone MRNA Metabolic Process RNA Biosynthetic Process Cellular Metabolic Process Cellular Component Assembly NcRNA Metabolic Process Termination Of RNA Polymerase II Transcription DNA-templated Transcription, Termination MRNA 3'-end Processing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA 3'-end Processing MRNA 3'-splice Site Recognition Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Histone Methylation Regulation Of RNA Metabolic Process MRNA Splice Site Selection Biosynthetic Process Histone H4-R3 Methylation Protein Methylation Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Alternative MRNA Splicing, Via Spliceosome Histone Arginine Methylation Peptidyl-arginine Methylation Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of RNA Splicing Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		accompanied active apoptotic apparently bax caspase cord demonstrating employed establish expressions immunofluorescent labeling localization location modulating motif nervous neuronal pc12 probe promotes regulating sci spinal suppressor traumatic trigger unregulated	androgen androgens ar ara70 ara70alpha ara70beta art benign coactivator coactivators corepressor cytoplasmic dysregulation ele1 exhibiting inhibitions internally luciferase mep50 ncoa4 p44 pca promotion spliced suppressive switch switches tblr1 versions
Tagcloud (Difference) ?		accompanied active apoptotic apparently bax caspase cord demonstrating employed establish expressions immunofluorescent labeling localization location modulating motif nervous neuronal pc12 probe promotes regulating sci spinal suppressor traumatic trigger unregulated	androgen androgens ar ara70 ara70alpha ara70beta art benign coactivator coactivators corepressor cytoplasmic dysregulation ele1 exhibiting inhibitions internally luciferase mep50 ncoa4 p44 pca promotion spliced suppressive switch switches tblr1 versions
Tagcloud (Intersection) ?