ZNF263 and SPG21

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZNF263	SPG21
Gene Name		zinc finger protein 263	spastic paraplegia 21 (autosomal recessive, Mast syndrome)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton	Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane Trans-Golgi Network Transport Vesicle
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Metal Ion Binding	Protein Binding CD4 Receptor Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated	Antigen Receptor-mediated Signaling Pathway
Pathways		Generic Transcription Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: CLK2 CLK3 DVL2 EFEMP2 GPATCH2L NME7 PCBD1 PLEKHF2 SCAND1 SPG21 SUFU TCAF1 TRIM41 ZNF446 ZSCAN1	37 interactors: AGTRAP AKIRIN2 ARL6IP1 ATPAF2 CCDC102B CCDC33 CD4 CMTM5 CRYAA CTPS2 CUTC DTX2 DTX3L EFHC2 FAM114A1 GGA2 GSK3A IKZF3 INCA1 KRT15 MID2 MTMR9 PRPS1 RABAC1 REEP6 RTN4 S100B SPRED2 TCF12 TCF4 TFG TRAF1 TRAF2 TRIM23 TRIM54 TRIM9 ZNF263
Entrez ID		10127	51324
HPRD ID		05008	10492
Ensembl ID		ENSG00000006194	ENSG00000090487
Uniprot IDs		D3DUC1 O14978	Q9NZD8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of RNA Splicing Regulation Of Gene Expression Neural Tube Closure Regulation Of Nitrogen Compound Metabolic Process Convergent Extension Involved In Neural Plate Elongation Determination Of Left/right Symmetry Determination Of Bilateral Symmetry Regulation Of Embryonic Development Smoothened Signaling Pathway Pattern Specification Process Neural Tube Formation Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway Embryonic Epithelial Tube Formation Epithelial Tube Formation Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Convergent Extension Involved In Organogenesis Tube Formation Morphogenesis Of Embryonic Epithelium Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Neural Plate Morphogenesis Neural Tube Development Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Tetrahydrobiopterin Biosynthetic Process Transcription, DNA-templated Protein Autophosphorylation	Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Protein Ubiquitination Regulation Of Cell Death Protein Modification By Small Protein Conjugation Negative Regulation Of Developmental Growth Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Striated Muscle Tissue Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Interleukin-2 Production Positive Regulation Of Cell Death Immune Response Negative Regulation Of Organ Growth Negative Regulation Of UDP-glucose Catabolic Process Induction By Virus Of Host Cell-cell Fusion Protein Palmitoleylation Regulation Of Intracellular Signal Transduction Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Striated Muscle Tissue Development Regulation Of Cellular Localization Negative Regulation Of Muscle Organ Development Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Pyrimidine Nucleotide Biosynthetic Process Regulation Of Intracellular Transport Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of SNARE Complex Assembly Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Urate Biosynthetic Process 'de Novo' CTP Biosynthetic Process Glycogen Metabolic Process Regulation Of Kinase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Differentiation Positive Regulation Of Protein Binding Regulation Of Skeletal Muscle Tissue Development Regulation Of Cellular Ketone Metabolic Process Gliogenesis Negative Regulation Of Growth Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Tagcloud ?		affymetrix arrays c10orf18 cabp4 capn10 centb1 converted fdr fractioned genechip glycerol hybridized or4c6 papillary ran sall1 serous smarcc2 spata13 splicing st st18 subcellular supernatants supraspliceosome transcriptome wdr78 zp2 zranb2
Tagcloud (Difference) ?		affymetrix arrays c10orf18 cabp4 capn10 centb1 converted fdr fractioned genechip glycerol hybridized or4c6 papillary ran sall1 serous smarcc2 spata13 splicing st st18 subcellular supernatants supraspliceosome transcriptome wdr78 zp2 zranb2
Tagcloud (Intersection) ?