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JAK2 and PTPN6
Number of citations of the paper that reports this interaction (PubMedID
8943354
)
43
Data Source:
HPRD
(in vivo)
JAK2
PTPN6
Description
Janus kinase 2
protein tyrosine phosphatase non-receptor type 6
Image
GO Annotations
Cellular Component
Euchromatin
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Caveola
Focal Adhesion
Cytoplasmic Side Of Plasma Membrane
Endomembrane System
Membrane
Extrinsic Component Of Plasma Membrane
Granulocyte Macrophage Colony-stimulating Factor Receptor Complex
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Endosome Lumen
Interleukin-12 Receptor Complex
Membrane Raft
Interleukin-23 Receptor Complex
Postsynapse
Glutamatergic Synapse
Extracellular Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Membrane
Protein-containing Complex
Specific Granule Lumen
Alpha-beta T Cell Receptor Complex
Extracellular Exosome
Tertiary Granule Lumen
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Growth Hormone Receptor Binding
Interleukin-12 Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Heme Binding
Signaling Receptor Activator Activity
Type 1 Angiotensin Receptor Binding
Acetylcholine Receptor Binding
Histone H3Y41 Kinase Activity
SH2 Domain Binding
Histone Binding
Identical Protein Binding
Phosphatidylinositol 3-kinase Binding
Insulin Receptor Substrate Binding
Metal Ion Binding
Peptide Hormone Receptor Binding
Phosphotyrosine Residue Binding
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Non-membrane Spanning Protein Tyrosine Phosphatase Activity
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Protein Binding
Hydrolase Activity
SH3 Domain Binding
Protein Kinase Binding
SH2 Domain Binding
Cell Adhesion Molecule Binding
Phosphorylation-dependent Protein Binding
Biological Process
Microglial Cell Activation
Positive Regulation Of Cytokine Production
Adaptive Immune Response
Immune System Process
Chromatin Organization
Chromatin Remodeling
Transcription By RNA Polymerase II
Apoptotic Process
Immune Response
Response To Oxidative Stress
Cell Adhesion
Signal Transduction
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Mesoderm Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Hormone-mediated Signaling Pathway
Positive Regulation Of Platelet Activation
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Cell-substrate Adhesion
Cytokine-mediated Signaling Pathway
Regulation Of Cell-cell Adhesion
Negative Regulation Of Cell-cell Adhesion
Actin Filament Polymerization
Myeloid Cell Differentiation
Cell Differentiation
Erythrocyte Differentiation
Positive Regulation Of Cell Migration
Axon Regeneration
Lipopolysaccharide-mediated Signaling Pathway
Nuclear Receptor-mediated Mineralocorticoid Signaling Pathway
Positive Regulation Of Insulin Secretion
Positive Regulation Of Type II Interferon Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Natural Killer Cell Proliferation
Response To Hydroperoxide
Tumor Necrosis Factor-mediated Signaling Pathway
Symbiont-induced Defense-related Programmed Cell Death
Response To Tumor Necrosis Factor
Post-embryonic Hemopoiesis
Intracellular Signal Transduction
Interleukin-12-mediated Signaling Pathway
Cellular Response To Interleukin-3
Interleukin-5-mediated Signaling Pathway
Collagen-activated Signaling Pathway
Interleukin-23-mediated Signaling Pathway
Interleukin-3-mediated Signaling Pathway
Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway
Erythropoietin-mediated Signaling Pathway
Thrombopoietin-mediated Signaling Pathway
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Protein Import Into Nucleus
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Activation Of Janus Kinase Activity
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of MAPK Cascade
Negative Regulation Of Neuron Apoptotic Process
Post-translational Protein Modification
T-helper 1 Cell Differentiation
Innate Immune Response
Positive Regulation Of MHC Class II Biosynthetic Process
Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Regulation Of Alpha-beta T Cell Activation
Response To Antibiotic
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Regulation Of Inflammatory Response
Modulation Of Chemical Synaptic Transmission
Positive Regulation Of Cell Activation
Positive Regulation Of NK T Cell Proliferation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Type II Interferon-mediated Signaling Pathway
Positive Regulation Of SMAD Protein Signal Transduction
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Growth Hormone Receptor Signaling Pathway
Negative Regulation Of Growth Hormone Receptor Signaling Pathway
Mammary Gland Epithelium Development
Interleukin-6-mediated Signaling Pathway
Positive Regulation Of Leukocyte Proliferation
Response To Interleukin-12
Interleukin-35-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Cellular Response To Dexamethasone Stimulus
Extrinsic Apoptotic Signaling Pathway
Cellular Response To Virus
Positive Regulation Of Cold-induced Thermogenesis
Defense Response To Symbiont
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Platelet Aggregation
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation
Positive Regulation Of Epithelial Cell Apoptotic Process
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Regulation Of Postsynapse To Nucleus Signaling Pathway
Negative Regulation Of 3'-UTR-mediated MRNA Stabilization
Positive Regulation Of T-helper 17 Type Immune Response
Positive Regulation Of Apoptotic Signaling Pathway
MAPK Cascade
Mitotic Cell Cycle
Pattern Recognition Receptor Signaling Pathway
Hematopoietic Progenitor Cell Differentiation
Neutrophil Activation Involved In Immune Response
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Protein Dephosphorylation
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Angiogenesis
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Platelet Formation
T Cell Costimulation
Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Mast Cell Activation Involved In Immune Response
Positive Regulation Of Cell Adhesion Mediated By Integrin
Peptidyl-tyrosine Dephosphorylation
Intracellular Signal Transduction
Megakaryocyte Development
T Cell Proliferation
T Cell Activation
Negative Regulation Of T Cell Proliferation
Natural Killer Cell Mediated Cytotoxicity
Regulation Of Apoptotic Process
Negative Regulation Of MAPK Cascade
Regulation Of B Cell Differentiation
Positive Regulation Of Angiogenesis
Negative Regulation Of Innate Immune Response
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Negative Regulation Of B Cell Receptor Signaling Pathway
Negative Regulation Of T Cell Receptor Signaling Pathway
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Type I Interferon-mediated Signaling Pathway
Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Inflammatory Response To Wounding
Negative Regulation Of Inflammatory Response To Wounding
CD27 Signaling Pathway
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of Neutrophil Activation
Epididymis Development
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Interleukin-6 signaling
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
Prolactin receptor signaling
Prolactin receptor signaling
Signaling by SCF-KIT
Signaling by Leptin
RMTs methylate histone arginines
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF activation
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
IL-6-type cytokine receptor ligand interactions
Signaling by moderate kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Cyclin D associated events in G1
Interferon gamma signaling
Regulation of IFNG signaling
Regulation of IFNG signaling
Interleukin-20 family signaling
Interleukin-35 Signalling
Signaling by Erythropoietin
Signaling by Erythropoietin
Interleukin-12 signaling
Interleukin-12 signaling
Interleukin-23 signaling
Interleukin-23 signaling
Interleukin-27 signaling
Interleukin-27 signaling
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phospholipase C gamma (PLCG)
Erythropoietin activates STAT5
Erythropoietin activates RAS
Erythropoietin activates RAS
Interleukin receptor SHC signaling
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by CSF3 (G-CSF)
Signaling by CSF3 (G-CSF)
Potential therapeutics for SARS
Inactivation of CSF3 (G-CSF) signaling
Inactivation of CSF3 (G-CSF) signaling
IFNG signaling activates MAPKs
Growth hormone receptor signaling
Growth hormone receptor signaling
Factors involved in megakaryocyte development and platelet production
GPVI-mediated activation cascade
Regulation of KIT signaling
Signaling by ALK
PECAM1 interactions
Co-inhibition by PD-1
Signal regulatory protein family interactions
Platelet sensitization by LDL
Interleukin-3, Interleukin-5 and GM-CSF signaling
CD22 mediated BCR regulation
Neutrophil degranulation
Interferon gamma signaling
Regulation of IFNG signaling
Interleukin-37 signaling
Interferon alpha/beta signaling
Interleukin receptor SHC signaling
Regulation of IFNA/IFNB signaling
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Nuclear events stimulated by ALK signaling in cancer
Growth hormone receptor signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Co-inhibition by BTLA
Drugs
2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one
XL019
5-phenyl-1H-indazol-3-amine
4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesulfonamide
4-[(2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-1H-BENZIMIDAZOL-6-YL)METHYL]MORPHOLIN-4-IUM
Ruxolitinib
Tofacitinib
Pacritinib
Baricitinib
Entrectinib
Fostamatinib
Fedratinib
Abrocitinib
Zanubrutinib
Pralsetinib
Tiludronic acid
Diseases
Polycythemia vera
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
18587394
21102463
23266558
)
Eosinophil count (
32888494
27863252
)
Eosinophil percentage of white cells (
32888494
)
Eosinophilic esophagitis (
34506852
)
HDL cholesterol (
30275531
)
Height (
31562340
)
Inflammatory bowel disease (
23128233
)
LDL cholesterol (
30275531
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Myeloproliferative neoplasms (
19287384
25849990
33057200
)
Neutrophil count (
32888494
)
Pediatric autoimmune diseases (
26301688
)
Platelet count (
24777453
32888494
27863252
28031487
)
Plateletcrit (
27863252
32888494
)
Psoriatic arthritis (
26626624
)
Red blood cell count (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Systemic lupus erythematosus (
27399966
33272962
)
Total cholesterol levels (
30275531
)
Ulcerative colitis (
19915573
20228799
21297633
26398853
)
White blood cell count (
32888494
)
Mean corpuscular hemoglobin concentration (
29403010
)
Red blood cell fatty acid levels (
25500335
)
Refractive error (
32231278
)
Interacting Genes
99 interacting genes:
ABL1
AGTR1
ARL11
ASS1
BCR
BRCA1
CBL
CCR5
CISH
CRLF2
CSF2RB
CSF3R
CTLA4
CXCR4
DNAJA3
EGFR
ELP2
EPOR
ERBB2
ERBB3
EZH2
FES
FYN
GHR
GRB10
GRB2
GTF2I
H3-4
HES1
HES5
HSFY1
HSPA8
HTR2A
IFNGR1
IFNGR2
IGF1R
IKBKG
IL12RB2
IL23R
IL3RA
IL4R
IL5RA
INSR
IRS1
IRS2
JAK1
JAK3
KIT
LEPR
LYN
MAP3K5
MDK
MPL
MST1R
NFKBIA
OSMR
PDGFRB
PIK3R1
PKD1
PLCG2
PPIA
PPP1CC
PPP2CA
PPP2R1B
PPP2R5A
PRLR
PRMT5
PTK2
PTK2B
PTPN1
PTPN11
PTPN12
PTPN6
PTPRC
RAF1
RBMX
SH2B1
SH2B2
SHC1
SIRPA
SOCS1
SOCS3
STAM
STAM2
STAP2
STAT1
STAT2
STAT3
STAT5A
STAT5B
TEC
TNFRSF1A
TRAF6
TSHR
TUB
UBASH3B
VAV1
VCP
YES1
118 interacting genes:
AATK
ABL1
ACTN1
ACTN4
BCR
BLNK
BTLA
CAV1
CBL
CCDC88A
CD22
CD247
CD300LF
CD33
CD5
CD72
CD79A
CD79B
CDK1
CEACAM1
CLEC4A
CNKSR1
CSF2RB
CTNNB1
CTNND1
CUZD1
CXCR4
DOK1
EGFR
EPOR
ERBB2
ERBB3
ERBB4
ESR1
FAS
FCGR2B
FCRL3
FGFR4
FHL3
FLT3
GAB2
GHR
GRB2
H2BC3
HOXA10
IFNAR1
IGF1R
IL2RB
IL4R
IL6ST
INSR
IRS2
IRS4
JAK1
JAK2
JAK3
KDR
KHDRBS1
KIR2DL3
KIR2DL5A
KIT
KLRA1P
KLRB1
KLRC1
LAIR1
LAT
LCK
LCP2
LIFR
LILRB2
LILRB4
LMTK2
LYN
MPIG6B
MS4A2
MYH9
NOS1
OLIG1
PAG1
PDGFRB
PECAM1
PIK3R1
PILRA
PILRB
PLCG2
PRKCA
PRKCD
PTK2B
PTK7
PTPN11
PTPRC
ROR1
ROR2
ROS1
SHC1
SIGLEC10
SIGLEC11
SIGLEC12
SIRPA
SLAMF6
SNCA
SOS1
SPATA2
SRC
SSTR2
STAT5B
STAT6
SYK
TFG
TLR10
TMEM62
TNFRSF1A
TRAF3
TRAF6
TREML1
TYK2
VAV1
ZAP70
Entrez ID
3717
5777
HPRD ID
00993
01475
Ensembl ID
ENSG00000096968
ENSG00000111679
Uniprot IDs
A8K910
B4DYV1
O60674
P29350
Q53XS4
PDB IDs
2B7A
2W1I
2XA4
3E62
3E63
3E64
3FUP
3IO7
3IOK
3JY9
3KCK
3KRR
3LPB
3Q32
3RVG
3TJC
3TJD
3UGC
3ZMM
4AQC
4BBE
4BBF
4C61
4C62
4D0W
4D0X
4D1S
4E4M
4E6D
4E6Q
4F08
4F09
4FVP
4FVQ
4FVR
4GFM
4GMY
4HGE
4IVA
4JI9
4JIA
4P7E
4YTC
4YTF
4YTH
4YTI
4Z32
4ZIM
5AEP
5CF4
5CF5
5CF6
5CF8
5HEZ
5I4N
5L3A
5TQ3
5TQ4
5TQ5
5TQ6
5TQ7
5TQ8
5USY
5USZ
5UT0
5UT1
5UT2
5UT3
5UT4
5UT5
5UT6
5WEV
5WIJ
5WIK
5WIL
5WIM
5WIN
6AAJ
6BBV
6BRW
6BS0
6BSS
6D2I
6DRW
6E2P
6E2Q
6G3C
6M9H
6OAV
6OBB
6OBF
6OBL
6OCC
6TPD
6VGL
6VN8
6VNB
6VNC
6VNE
6VNF
6VNG
6VNH
6VNI
6VNJ
6VNK
6VNL
6VNM
6VS3
6VSN
6WTN
6WTO
6WTP
6WTQ
6X8E
6XJK
7F7W
7JYO
7JYQ
7LL4
7LL5
7Q7I
7Q7K
7Q7L
7Q7W
7REE
7RN6
7SZW
7T0P
7T1T
7TEU
7UYW
8B8N
8B8U
8B99
8B9E
8B9H
8BA2
8BA3
8BA4
8BAB
8BAK
8BM2
8BPV
8BPW
8BX6
8BX9
8BXC
8BXH
8C08
8C09
8C0A
8CZ9
8EX0
8EX1
8EX2
8EXK
8EYA
8EYB
8F88
8G6Z
8G8O
8G8X
1FPR
1GWZ
1X6C
2B3O
2RMX
2YU7
3PS5
4GRY
4GRZ
4GS0
4HJP
4HJQ
6SM5
8YHI
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Cytokine-mediated Signaling Pathway
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cell Population Proliferation
Regulation Of Multicellular Organismal Process
Enzyme-linked Receptor Protein Signaling Pathway
Cytokine Receptor Activity
Regulation Of Signal Transduction
Cell Surface Receptor Signaling Pathway Via STAT
Receptor Complex
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Multicellular Organismal Process
Regulation Of Cell Adhesion
Plasma Membrane
Regulation Of Signaling
Regulation Of Cell Communication
Protein Tyrosine Kinase Activity
Immune System Process
Regulation Of Immune System Process
Positive Regulation Of Signal Transduction
Cytokine Binding
Regulation Of Cell Differentiation
Regulation Of Developmental Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Cell-cell Adhesion
Positive Regulation Of Metabolic Process
Positive Regulation Of Immune System Process
Regulation Of Cell Activation
Cell Activation
Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Multicellular Organismal Development
Regulation Of Cell Development
Positive Regulation Of Lymphocyte Activation
Regulation Of Leukocyte Cell-cell Adhesion
Phosphotyrosine Residue Binding
Positive Regulation Of Cell Activation
Growth Hormone Receptor Signaling Pathway
Leukocyte Activation
Regulation Of Lymphocyte Activation
Positive Regulation Of Cell-cell Adhesion
Regulation Of Hemopoiesis
Regulation Of MAPK Cascade
Regulation Of Programmed Cell Death
Response To Cytokine
Regulation Of T Cell Activation
Cell Surface Receptor Signaling Pathway
Signal Transduction
Plasma Membrane
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Tyrosine Kinase Activity
Regulation Of Immune Response
Regulation Of Immune System Process
Enzyme-linked Receptor Protein Signaling Pathway
Immune System Process
Cytokine-mediated Signaling Pathway
Regulation Of Cell Activation
Immune Response-regulating Signaling Pathway
Leukocyte Activation
Cell Activation
Regulation Of MAPK Cascade
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Lymphocyte Activation
Membrane
Lymphocyte Activation
Receptor Complex
Positive Regulation Of MAPK Cascade
Positive Regulation Of Signal Transduction
Peptidyl-tyrosine Phosphorylation
Protein Kinase Activity
Regulation Of Signal Transduction
Regulation Of T Cell Activation
Regulation Of Intracellular Signal Transduction
Immune Response
Positive Regulation Of Intracellular Signal Transduction
Adaptive Immune Response
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Cell Adhesion
Regulation Of Cell-cell Adhesion
Protein Phosphatase Binding
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Immune Response
Regulation Of Multicellular Organismal Process
Protein Phosphorylation
Regulation Of Leukocyte Proliferation
External Side Of Plasma Membrane
Fc Receptor Signaling Pathway
Kinase Activity
Immune Response-activating Signaling Pathway
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Cell Population Proliferation
B Cell Activation
Mononuclear Cell Differentiation
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Tagcloud (Intersection)
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