JAK2 and VAV1

Number of citations of the paper that reports this interaction (PMID 7530656)
18

Data Source:
HPRD (in vivo)

		JAK2	VAV1
Gene Name		Janus kinase 2	vav 1 guanine nucleotide exchange factor
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Caveola Nuclear Matrix Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Endosome Lumen Membrane Raft	Cytosol Plasma Membrane Cell-cell Junction
	Molecular Function	Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Growth Hormone Receptor Binding Interleukin-12 Receptor Binding Protein Binding ATP Binding Protein C-terminus Binding Protein Kinase Binding Heme Binding Type 1 Angiotensin Receptor Binding Acetylcholine Receptor Binding Histone Kinase Activity (H3-Y41 Specific) SH2 Domain Binding Histone Binding Phosphatidylinositol 3-kinase Binding Insulin Receptor Substrate Binding Peptide Hormone Receptor Binding	Sequence-specific DNA Binding Transcription Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Rac Guanyl-nucleotide Exchange Factor Activity Metal Ion Binding
	Biological Process	Activation Of MAPKK Activity Chromatin Organization Protein Phosphorylation Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Movement Of Cell Or Subcellular Component Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration JAK-STAT Cascade Tyrosine Phosphorylation Of STAT Protein STAT Protein Import Into Nucleus Mesoderm Development Blood Coagulation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Hormone-mediated Signaling Pathway Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Negative Regulation Of Cell-cell Adhesion Actin Filament Polymerization Cell Differentiation Erythrocyte Differentiation Positive Regulation Of Cell Migration Axon Regeneration Mineralocorticoid Receptor Signaling Pathway Positive Regulation Of Insulin Secretion Response To Lipopolysaccharide Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Protein Import Into Nucleus, Translocation Response To Hydroperoxide Tumor Necrosis Factor-mediated Signaling Pathway Host Programmed Cell Death Induced By Symbiont Response To Tumor Necrosis Factor Histone H3-Y41 Phosphorylation Intracellular Signal Transduction Interleukin-12-mediated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Tyrosine Phosphorylation Of Stat3 Protein Tyrosine Phosphorylation Of Stat5 Protein Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Activation Of JAK2 Kinase Activity Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Negative Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Heart Contraction Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Antibiotic Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Activation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Growth Hormone Receptor Signaling Pathway Mammary Gland Epithelium Development Response To Interleukin-12 Extrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Regulation Of Transcription, DNA-templated Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation Neutrophil Chemotaxis T Cell Costimulation Positive Regulation Of Rac GTPase Activity Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Positive Regulation Of Apoptotic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Small GTPase Mediated Signal Transduction Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway
Pathways		Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Interferon gamma signaling Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 5 (TLR5) Cascade Interleukin receptor SHC signaling Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Prolactin receptor signaling SHC-mediated signalling TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation GPCR downstream signaling Signaling by VEGF Downstream signal transduction Toll Like Receptor 3 (TLR3) Cascade Signalling to RAS Interleukin-2 signaling Platelet activation, signaling and aggregation Frs2-mediated activation Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade Interferon Signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events RMTs methylate histone arginines Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades Nuclear signaling by ERBB4 Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Interleukin receptor SHC signaling GPVI-mediated activation cascade Signaling by GPCR FCERI mediated MAPK activation SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Toll Like Receptor 9 (TLR9) Cascade Signaling by PDGF DAP12 interactions G-protein beta:gamma signalling Chromatin organization GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Factors involved in megakaryocyte development and platelet production Signaling by ERBB4 Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins Chromatin modifying enzymes SHC1 events in ERBB4 signaling Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Growth hormone receptor signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events ERK activation Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation G beta:gamma signalling through PI3Kgamma Downstream signaling of activated FGFR Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer ERK2 activation SHC1 events in EGFR signaling FRS2-mediated cascade IRS-mediated signalling ERK2 activation Regulation of IFNG signaling	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Signaling by PDGF DAP12 interactions GAB1 signalosome CD28 co-stimulation Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Signaling by Interleukins Signaling by VEGF Signaling by Rho GTPases Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System Costimulation by the CD28 family PIP3 activates AKT signaling VEGFA-VEGFR2 Pathway Rho GTPase cycle PI3K events in ERBB2 signaling Downstream signaling of activated FGFR VEGFR2 mediated vascular permeability Regulation of signaling by CBL G alpha (12/13) signalling events Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer p75 NTR receptor-mediated signalling NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer CD28 dependent Vav1 pathway Signaling by FGFR NRAGE signals death through JNK GPVI-mediated activation cascade FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS		Crohn's disease ( 18587394 21102463 23266558) Inflammatory bowel disease ( 23128233) Myeloproliferative neoplasms ( 19287384) Ulcerative colitis ( 19915573 20228799 21297633)	Periodontitis ( 23459936)
Protein-Protein Interactions		94 interactors: ABL1 AGTR1 ASS1 BCR BRCA1 CCR5 CRLF2 CSF2RB CSF3R CTLA4 CXCR4 DNAJA3 EGFR ELP2 EPOR ERBB2 ERBB3 EZH2 FES FYN GHR GRB10 GRB2 GTF2I HES1 HES5 HIST3H3 HSPA8 HTR2A IFNGR1 IFNGR2 IGF1R IKBKG IL12RB2 IL23R IL3RA IL4R IL5RA INSR IRS1 IRS2 JAK3 KIT LEPR LYN MAP3K5 MDK MPL MST1R NFKBIA OSMR PDGFRB PIK3R1 PKD1 PLCG2 PPIA PPP1CC PPP2CA PPP2R1B PPP2R5A PRLR PRMT5 PTK2 PTK2B PTPN1 PTPN11 PTPN12 PTPN6 PTPRC RAF1 RBMX SH2B1 SH2B2 SHC1 SIRPA SOCS1 SOCS3 STAM STAM2 STAP2 STAT1 STAT2 STAT3 STAT5A STAT5B TEC TNFRSF1A TRAF6 TSHR TUB UBASH3B VAV1 VCP YES1	77 interactors: ABL1 ACTA1 AOC3 ARHGDIA ARHGDIB BCR BLNK BTK CASP3 CBL CBLB CD19 CDC42 CRK CXCR4 DNM2 DOCK2 DOK1 EGFR EMD EPOR ERBB2 ERBB3 EZH2 FGFR1 FYN GRB2 HCK HNRNPK HRAS IL6ST INSR JAK2 JUN KHDRBS1 LAT LCK LCP2 LMNA MAPK1 MERTK MET NEK3 PAG1 PDGFRB PHAX PIK3R1 PLCG1 PRKCQ PRLR PTK2B PTPN22 PTPN6 RAC1 RACGAP1 RAF1 RHOA RHOG S100B SH3BP2 SHB SHC1 SIAH1 SIAH2 SLA SOCS1 SYK TEC TUBA1A TUBA4A TUBB TYK2 XRCC5 XRCC6 ZAP70 ZNF655 ZYX
Entrez ID		3717	7409
HPRD ID		00993	01284
Ensembl ID		ENSG00000096968	ENSG00000141968
Uniprot IDs		O60674	B2R8B5 P15498 Q96D37
PDB IDs		2B7A 2W1I 2XA4 3E62 3E63 3E64 3FUP 3IO7 3IOK 3JY9 3KCK 3KRR 3LPB 3Q32 3RVG 3TJC 3TJD 3UGC 3ZMM 4AQC 4BBE 4BBF 4E4M 4E6D 4E6Q 4F08 4F09 4FVP 4FVQ 4FVR 4GFM 4GMY 4HGE 4IVA 4JI9 4JIA	2CRH 2LCT 2MC1 2ROR 3BJI 3KY9
Enriched GO Terms of Interacting Partners?		Response To Organic Substance Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Defense Response Signaling Cell Communication Cellular Response To Stimulus Immune System Process Cellular Response To Cytokine Stimulus Regulation Of Immune Response Cytokine-mediated Signaling Pathway Innate Immune Response Response To Cytokine Growth Hormone Receptor Signaling Pathway Immune Response Response To Stimulus Cellular Response To Growth Hormone Stimulus Intracellular Signal Transduction Regulation Of Immune System Process Response To Growth Hormone Regulation Of Signal Transduction JAK-STAT Cascade Cellular Response To Peptide Hormone Stimulus Response To Stress Regulation Of Kinase Activity JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Cellular Response To Peptide Regulation Of Signaling Cellular Response To Organonitrogen Compound Regulation Of Phosphorylation Response To Hormone Regulation Of Cell Proliferation Response To Organonitrogen Compound Cellular Response To Hormone Stimulus Peptidyl-tyrosine Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Peptide Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Response To Peptide Hormone Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Kinase Activity Response To External Stimulus Regulation Of Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Innate Immune Response Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Immune System Process Regulation Of Signaling Regulation Of Immune System Process Immune Response Cellular Response To Stimulus Regulation Of Immune Response Positive Regulation Of Signal Transduction Defense Response Cell Surface Receptor Signaling Pathway Response To Stimulus Fc-epsilon Receptor Signaling Pathway Signal Transduction Response To Wounding Peptidyl-tyrosine Phosphorylation Response To Organic Substance Cell Activation Wound Healing Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Organic Substance ERBB Signaling Pathway Cell Differentiation Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cell Communication Immune Response-activating Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Neurotrophin TRK Receptor Signaling Pathway Blood Coagulation Neurotrophin Signaling Pathway Hemostasis Antigen Receptor-mediated Signaling Pathway Locomotion System Development Cellular Response To Growth Factor Stimulus Response To Stress Peptidyl-tyrosine Autophosphorylation Regulation Of Body Fluid Levels Platelet Activation Response To Growth Factor Protein Autophosphorylation Developmental Process
Tagcloud ?		activated allows alternative autophosphorylation bound complementation configurations conformation consistent crystallographic cytokine dimeric dimerization dimers distinct domains erythropoietin exist forms fragment hormone kinases ligand obtain prevents thought undergo unliganded	abilities abnormally blocking colony csf1 cytoskeleton effector erk exclusively fibrosis h358 hematopoietic herein infiltrating lung microenvironment organization scaffold scid secrete secretome silenced smaller stimulating supported supporting talk transcriptome transducer
Tagcloud (Difference) ?		activated allows alternative autophosphorylation bound complementation configurations conformation consistent crystallographic cytokine dimeric dimerization dimers distinct domains erythropoietin exist forms fragment hormone kinases ligand obtain prevents thought undergo unliganded	abilities abnormally blocking colony csf1 cytoskeleton effector erk exclusively fibrosis h358 hematopoietic herein infiltrating lung microenvironment organization scaffold scid secrete secretome silenced smaller stimulating supported supporting talk transcriptome transducer
Tagcloud (Intersection) ?