JAK2 and PKD1

  • Number of citations of the paper that reports this interaction (PMID 12007403)
  • 103
  • Data Source:
  • HPRD (in vitro)

JAK2

PKD1

Gene Name Janus kinase 2 polycystic kidney disease 1 (autosomal dominant)
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 94 interactors: ABL1 AGTR1 ASS1 BCR BRCA1 CCR5 CRLF2 CSF2RB CSF3R CTLA4 CXCR4 DNAJA3 EGFR ELP2 EPOR ERBB2 ERBB3 EZH2 FES FYN GHR GRB10 GRB2 GTF2I HES1 HES5 HIST3H3 HSPA8 HTR2A IFNGR1 IFNGR2 IGF1R IKBKG IL12RB2 IL23R IL3RA IL4R IL5RA INSR IRS1 IRS2 JAK3 KIT LEPR LYN MAP3K5 MDK MPL MST1R NFKBIA OSMR PDGFRB PIK3R1 PKD1 PLCG2 PPIA PPP1CC PPP2CA PPP2R1B PPP2R5A PRLR PRMT5 PTK2 PTK2B PTPN1 PTPN11 PTPN12 PTPN6 PTPRC RAF1 RBMX SH2B1 SH2B2 SHC1 SIRPA SOCS1 SOCS3 STAM STAM2 STAP2 STAT1 STAT2 STAT3 STAT5A STAT5B TEC TNFRSF1A TRAF6 TSHR TUB UBASH3B VAV1 VCP YES1 25 interactors: ACTN1 ATF7IP BCAR1 CDH1 COL1A1 COL2A1 CTNNA1 CTNNB1 DES FN1 HDAC9 JAK2 JUP KRT18 KRT8 MARK2 PKD2 PTK2 PXN RGS7 SIAH1 SRC TLN1 VCL VIM
Entrez ID 3717 5310
HPRD ID 00993 03203
Ensembl ID ENSG00000096968 ENSG00000008710
Uniprot IDs O60674 P98161
PDB IDs 2B7A 2W1I 2XA4 3E62 3E63 3E64 3FUP 3IO7 3IOK 3JY9 3KCK 3KRR 3LPB 3Q32 3RVG 3TJC 3TJD 3UGC 3ZMM 4AQC 4BBE 4BBF 4E4M 4E6D 4E6Q 4F08 4F09 4FVP 4FVQ 4FVR 4GFM 4GMY 4HGE 4IVA 4JI9 4JIA 1B4R
Enriched GO Terms of Interacting Partners?
Tagcloud ?
activated  allows  alternative  autophosphorylation  bound  complementation  configurations  conformation  consistent  crystallographic  cytokine  dimeric  dimerization  dimers  distinct  domains  erythropoietin  exist  forms  fragment  hormone  kinases  ligand  obtain  prevents  thought  undergo  unliganded 
acts  adpkd  autosomal  chaperone  coil  coiled  complexing  determinant  disrupted  distal  glycoform  gps  heterozygotes  illustrating  inherited  interbreeding  maturation  mature  missense  nephropathy  nonequimolar  pathogenic  pc1  pc2  pkd2  polycystic  polycystin  progressive  severity 
Tagcloud (Difference) ?
activated  allows  alternative  autophosphorylation  bound  complementation  configurations  conformation  consistent  crystallographic  cytokine  dimeric  dimerization  dimers  distinct  domains  erythropoietin  exist  forms  fragment  hormone  kinases  ligand  obtain  prevents  thought  undergo  unliganded 
acts  adpkd  autosomal  chaperone  coil  coiled  complexing  determinant  disrupted  distal  glycoform  gps  heterozygotes  illustrating  inherited  interbreeding  maturation  mature  missense  nephropathy  nonequimolar  pathogenic  pc1  pc2  pkd2  polycystic  polycystin  progressive  severity 
Tagcloud (Intersection) ?